DEHP metabolites

ID1445
NameDEHP metabolites
SynonymsDi(2-ethylhexyl) phthalate metabolites
StructureThumb
Description
GroupPhthalates
Sub-groupPhthalate monoesters
Exposure sourcePollution
UsePlasticizers
CAS number
PubChem ID
ChEBI ID
FooDB ID
HMDB ID

Biomarker measurements

Biomarker concentration values

IDParent IDDepthSubject groupPopulationCountryCountry codeCohortTime definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianAdjustment typeAdjusted onRegressed onExpressed asPublication
186880AllMinority childrenUnited StatesUSbaseline; 2 weeks; 1 month; 2 months, 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
35521.045.6481.23587.56901.3ug/g521.0 ug/g481.2 ug/gDensityCreatinineTeitelbaum 2008
187420AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
3314.538.370.6108.0146.0311.03001.0ng/mL0.1 mg/LCrudeFrederiksen 2013
187580AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
333.2614.154.0883.211.0290.0580.0ng/mL0.1 mg/LCrudeFrederiksen 2013
187720AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
3321.427.452.285.6119.1217.02575.0ng/mL0.1 mg/LCrudeFrederiksen 2013
188890AllWomen seeking evaluation and treatment for infertility at the Massachusetts General HospitalUnited StatesUSEARTH (Environment and Reproductive Health)baseline; 12 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
1370.20.330.56ug/L0.0 mg/LDensitySpecific gravityBraun 2012
18890188891AllWomen seeking evaluation and treatment for infertility at the Massachusetts General HospitalUnited StatesUSEARTH (Environment and Reproductive Health)baseline; 12 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
1370.180.30.52ug/L0.0 mg/LDensitySpecific gravityBraun 2012
188970AllWomen seeking evaluation and treatment for infertility at the Massachusetts General HospitalUnited StatesUSEARTH (Environment and Reproductive Health)baseline; 15 weeks; 28 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
1370.180.360.69ug/L0.0 mg/LDensitySpecific gravityBraun 2012
18898188971AllWomen seeking evaluation and treatment for infertility at the Massachusetts General HospitalUnited StatesUSEARTH (Environment and Reproductive Health)baseline; 15 weeks; 28 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
1370.170.310.66ug/L0.0 mg/LDensitySpecific gravityBraun 2012
18922205031AllWomenUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
40421.4120.4361.71520.5pmol/mg0.4 umol/g0.4 umol/gDensityCreatinineTownsend 2013
193500ChildrenNursery-school children and their teachers and parents in rural southern GermanyGermanyDEUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
3628.798.8206.0464.0ug/g98.8 ug/gDensityCreatinineKoch 2004
193540AdultsNursery-school children and their teachers and parents in rural southern GermanyGermanyDEUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
1920.550.9108.0124.0ug/g50.9 ug/gDensityCreatinineKoch 2004
194540ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
14595.011.031.047.065.0109.0230.01437.0ug/g95.0 ug/g65.0 ug/gDensityCreatinineFrederiksen 2013
194710MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
14570.09.816.028.040.052.0121.02700.0ug/g70.0 ug/g40.0 ug/gDensityCreatinineFrederiksen 2013
195130ChildrenMother-child pairs in the industrialized city of DuisburgGermanyDEThe Duisburg birth cohort studyUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
104100.054.348.161.3ug/g54.3 ug/gDensityCreatinineKasper-Sonnenberg 2012
195390MothersMother-child pairs in the industrialized city of DuisburgGermanyDEThe Duisburg birth cohort studyUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
10324.221.027.8ug/g24.2 ug/gDensityCreatinineKasper-Sonnenberg 2012
202630AllChildren and adolescentsDenmarkDKCopenhagen Puberty Study 2006–2008Urine, 24-hLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
12917.050.073.0107.0198.0256.0352.0733.0ng/mL0.1 mg/LCrudeFrederiksen 2011
202790AllChildren and adolescentsDenmarkDKCopenhagen Puberty Study 2006–2008Urine, first morning spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
12923.074.0115.0183.0277.0514.0685.01580.0ng/mL0.2 mg/LCrudeFrederiksen 2011
205180AllHmong womenUnited StatesUSFox River Environment and Diet Study cohort in Green Bay, Wisconsinbaseline; 15 days; 29.5 daysUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
4567.32.114.541.068.9128.7462.1540.9ug/g67.3 ug/g68.9 ug/gDensityCreatininePeck 2010

Intake values

No data available

Correlation values

No data available

Reproducibility values

IDMst. IDSubject groupPopulationCountryCountry codeCohortTime definitionBiological specimenExperimental methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication
34318688AllMinority childrenUnited StatesUSbaseline; 2 weeks; 1 month; 2 months, 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
521.0481.2ug/gCreatinine350.230.780.24Teitelbaum 2008
38818742AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
108.0ng/mL330.210.00.450.4720.123Frederiksen 2013
39718772AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
85.6ng/mL330.060.00.30.3990.027Frederiksen 2013
40018758AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
83.2ng/mL330.190.00.50.5710.138Frederiksen 2013
49318889AllWomen seeking evaluation and treatment for infertility at the Massachusetts General HospitalUnited StatesUSEARTH (Environment and Reproductive Health)baseline; 12 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
0.33ug/LSpecific gravity1370.11Braun 2012
49418890AllWomen seeking evaluation and treatment for infertility at the Massachusetts General HospitalUnited StatesUSEARTH (Environment and Reproductive Health)baseline; 12 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
0.3ug/LSpecific gravity1370.12Braun 2012
50118897AllWomen seeking evaluation and treatment for infertility at the Massachusetts General HospitalUnited StatesUSEARTH (Environment and Reproductive Health)baseline; 15 weeks; 28 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
0.36ug/LSpecific gravity1370.08Braun 2012
50218898AllWomen seeking evaluation and treatment for infertility at the Massachusetts General HospitalUnited StatesUSEARTH (Environment and Reproductive Health)baseline; 15 weeks; 28 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
0.31ug/LSpecific gravity1370.09Braun 2012
52718922AllWomenUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
421.4361.7pmol/mgCreatinine400.380.160.650.510.31Townsend 2013
90520518AllHmong womenUnited StatesUSFox River Environment and Diet Study cohort in Green Bay, Wisconsinbaseline; 15 days; 29.5 daysUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
67.368.9ug/gCreatinine450.160.00.3Peck 2010