JPHC (Japan Public Health Center-based Prospective Study on Cancer and Cardiovascular Diseases) (Cohort)

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ID	19
Name	JPHC (Japan Public Health Center-based Prospective Study on Cancer and Cardiovascular Diseases)
Acronym	JPHC
Description	The JPHC Study (formerly called "Koseisho Multipurpose Prospective Cohort Study") began in 1990 (Cohort I) and 1993 (Cohort II). It covers 11 public health center areas throughout Japan and includes a total of 140 420 residents. The study's design includes a baseline survey with a self-administered questionnaire on lifestyle and collection of blood and health checkup data; a follow-up system for mortality, migration, and incidence of cancer and cardiovascular diseases; an additional follow-up survey after 5 and 10 years; and distribution of a newsletter. The JPHC study is expected to provide evidence for the prevention and control of cancer and cardiovascular diseases in the 21st century.
Country	Japan
PubMed ID	11763137
URL
Cohort design	Observation

Publications with JPHC (Japan Public Health Center-based Prospective Study on Cancer and Cardiovascular Diseases)

Title	First author	Year
Validity and reproducibility of a self-administered food-frequency questionnaire to assess isoflavone intake in a japanese population in comparison with dietary records and blood and urine isoflavones	Yamamoto	2001
Effect of cooking loss in the assessment of vitamin intake for epidemiological data in Japan	Kobayashi	2011
Single measurement of serum phospholipid fatty acid as a biomarker of specific fatty acid intake in middle-aged Japanese men	Kobayashi	2001
Plasma levels of carotenoids, retinol and tocopherol and the risk of gastric cancer in Japan: a nested case-control study	Persson	2008
Plasma 25-hydroxy vitamin D and subsequent prostate cancer risk in a nested Case-Control study in Japan: The JPHC study	Sawada	2017
Plasma vitamin D and risk of colorectal cancer: the Japan Public Health Center-Based Prospective Study	Otani	2007
Plasma folate and risk of colorectal cancer in a nested case-control study: the Japan Public Health Center-based prospective study	Otani	2008
Plasma isoflavones and risk of primary liver cancer in Japanese women and men with hepatitis virus infection: a nested case-control study	Michikawa	2015
Plasma isoflavone concentrations are not associated with gastric cancer risk among Japanese men and women	Hara	2013
Plasma isoflavones and the risk of lung cancer in women: a nested case-control study in Japan	Shimazu	2011
Plasma tea polyphenol levels and subsequent risk of breast cancer among Japanese women: a nested case-control study	Iwasaki	2010
Plasma tea polyphenols and gastric cancer risk: a case-control study nested in a large population-based prospective study in Japan	Sasazuki	2008
Plasma isoflavones and subsequent risk of prostate cancer in a nested case-control study: the Japan Public Health Center	Kurahashi	2008
Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: a nested case-control study from the Japan Public Health Center-based prospective study group	Iwasaki	2008
Plasma 25-hydroxyvitamin D concentration and subsequent risk of total and site specific cancers in Japanese population: large case-cohort study within Japan Public Health Center-based Prospective Study cohort	Budhathoki	2018

Biomarker data

Measurements of biomarkers in JPHC (Japan Public Health Center-based Prospective Study on Cancer and Cardiovascular Diseases)

Concentration values

ID	Parent ID	Depth	Subject group	Population	Country	Cohort	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Measurement size	Detected (nb)	Detected (%)	Detected only?	Arithmethic mean	Arithmethic SD	Geometric mean	Geometric SD	Min	Min (detected)	Percentile_05	Percentile_10	Percentile_25	Median	Percentile_75	Percentile_90	Percentile_95	Max	Interquartile range	Mean 95% CI lower	Mean 95% CI upper	GMean 95% CI lower	GMean 95% CI upper	Unit	Converted arithmetic mean	Converted geometric mean	Converted median	Converted unit	Adjustment type	Adjusted on	Regressed on	Expressed as	Publication

Reproducibility values

ID	Excretion ID	Subject group	Population	Country	Cohort	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Arithmetic mean	Geometric mean	Median	Unit	Adjusted on	Reproducibility size	ICC	ICC 95% CI lower	ICC 95% CI upper	CV% WS	CV% BS	VAR WS	VAR BS	Publication

Associations of biomarkers and exposures in JPHC (Japan Public Health Center-based Prospective Study on Cancer and Cardiovascular Diseases)

Correlation values

ID	Intake ID	Excretion ID	Subject group	Population	Country	Cohort	Intake Time definition	Intake Assessment method	Intake	Intake detail	Supplement intakes included?	Intake Arithmetic mean	Intake Geometric mean	Intake Median	Intake Unit	Intake Adjusted on	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Biomarker Arithmetic mean	Biomarker Geometric mean	Biomarker Median	Biomarker Unit	Biomarker Adjusted on	Correlation size	Correlation type	Correlation value	Correlation 95% CI lower	Correlation 95% CI upper	Correlation p-value	Significant?	Measurement adjustment	Deattenuated?	Covariates	Publication

Metabolomic associations

ID	Intake ID	Excretion ID	Subject group	Population	Country	Cohort	No. of subjects	Intake Assessment method	Intake	Intervention dose	Biospecimen	Analytical method	Biomarker	Structural identification	Feature selection	Area under curve	Sensitivity	Specificity	PLS-DA VIP	Beta coefficient	Beta coefficient p-value	ANOVA p-value	Publication

Associations of biomarkers and cancer risk in JPHC (Japan Public Health Center-based Prospective Study on Cancer and Cardiovascular Diseases)

Cancer associations

ID	Excretion ID	Subject group	Population	Country	Cohort	No. of subjects	No. of cases	No. of controls	Biospecimen	Analytical method	Biomarker	Biomarker detail	Cancer	Study design	Publication

Exposure data

Measurements of exposures in JPHC (Japan Public Health Center-based Prospective Study on Cancer and Cardiovascular Diseases)

Intake values

ID	Parent ID	Depth	Subject group	Population	Country	Cohort	Intake Time definition	Intake assessment tool	Intake food coverage	Intake time coverage	Intake Assessment method	Intake	Intake detail	Food description	Supplement intakes included?	Measurement size	Detected (nb)	Detected (%)	Detected only?	Arithmethic mean	Arithmethic SD	Geometric mean	Geometric SD	Min	Min (detected)	Percentile_05	Percentile_10	Percentile_25	Median	Percentile_75	Percentile_90	Percentile_95	Max	Interquartile range	Mean 95% CI lower	Mean 95% CI upper	GMean 95% CI lower	GMean 95% CI upper	Unit	Converted arithmetic mean	Converted geometric mean	Converted median	Converted unit	Adjustment type	Adjusted on	Regressed on	Expressed as	Publication