PHS (Physicians' Health Study) (Cohort)

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ID212
NamePHS (Physicians' Health Study)
AcronymPHS ; PHS I ; PHS II
DescriptionThe Physicians' Health Study is a randomized, double-blind, placebo-controlled trial among healthy US male physicians. The original randomized trial, the Physicians' Health Study I, was to test the benefits and risks of aspirin and beta carotene in the primary prevention of cardiovascular disease and cancer ; it started in 1982 and ended in 1995. A second randomized trial, the Physicians' Health Study II, was to test the balance of benefits and risks of three other widely used, but as yet unproven, supplements for the primary prevention of cardiovascular disease, cancer, age-related eye disease, and cognitive decline--vitamin E, vitamin C, and a multivitamin ; it started in 1997 and ended in 2011.
CountryUnited States
PubMed ID
URLhttp://phs.bwh.harvard.edu/
Cohort designIntervention

Publications with PHS (Physicians' Health Study)

TitleFirst authorYear
Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysisGann1999
Circulating levels of vitamin D and colon and rectal cancer: the Physicians' Health Study and a meta-analysis of prospective studiesLee2011
Prospective study of plasma vitamin B6 and risk of colorectal cancer in menLee2009
Effect Modification by Time Since Blood Draw on the Association Between Circulating Fatty Acids and Prostate Cancer RiskYang2016
Blood levels of long-chain polyunsaturated fatty acids, aspirin, and the risk of colorectal cancerHall2007

Biomarker data

Measurements of biomarkers in PHS (Physicians' Health Study)

Concentration values

IDParent IDDepthSubject groupPopulationCountryCohortBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianConverted unitAdjustment typeAdjusted onRegressed onExpressed asPublication

Reproducibility values

IDExcretion IDSubject groupPopulationCountryCohortBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication

Associations of biomarkers and exposures in PHS (Physicians' Health Study)

Correlation values

IDIntake IDExcretion IDSubject groupPopulationCountryCohortIntake Time definitionIntake Assessment methodIntakeIntake detailSupplement intakes included?Intake Arithmetic meanIntake Geometric meanIntake MedianIntake UnitIntake Adjusted onBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailBiomarker Arithmetic meanBiomarker Geometric meanBiomarker MedianBiomarker UnitBiomarker Adjusted onCorrelation sizeCorrelation typeCorrelation valueCorrelation 95% CI lowerCorrelation 95% CI upperCorrelation p-valueSignificant?Measurement adjustmentDeattenuated?CovariatesPublication

Metabolomic associations

IDIntake IDExcretion IDSubject groupPopulationCountryCohortNo. of subjectsIntake Assessment methodIntakeIntervention doseBiospecimenAnalytical methodBiomarkerStructural identificationFeature selectionArea under curveSensitivitySpecificityPLS-DA VIPBeta coefficientBeta coefficient p-valueANOVA p-valuePublication

Associations of biomarkers and cancer risk in PHS (Physicians' Health Study)

Cancer associations

IDExcretion IDSubject groupPopulationCountryCohortNo. of subjectsNo. of casesNo. of controlsBiospecimenAnalytical methodBiomarkerBiomarker detailCancerStudy designPublication

Exposure data

Measurements of exposures in PHS (Physicians' Health Study)

Intake values

IDParent IDDepthSubject groupPopulationCountryCohortIntake Time definitionIntake assessment toolIntake food coverageIntake time coverageIntake Assessment methodIntakeIntake detailFood descriptionSupplement intakes included?Measurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianConverted unitAdjustment typeAdjusted onRegressed onExpressed asPublication