NHS (Nurses' Health Study) (Cohort)

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ID36
NameNHS (Nurses' Health Study)
AcronymNHS ; NHSII ; NHSIII
DescriptionThe Nurses' Health Study (NHS), is a series of prospective studies that examine epidemiology and the long-term effects of nutrition, hormones, environment, and nurses' work-life on health and disease development. The NHS was established in 1976 among 121 700 U.S. female registered nurses, ages 30 to 55 years. The NHSII was established in 1989 among 116 430 female registered nurses, ages 25 to 42 years. In 1989-1990, 32 826 NHS participants, ages 43-70 years, provided blood samples and responded to a short questionnaire. The NHSII blood collection occurred in 1996-1999, when 29 611 participants who were cancer-free and ages 32-54 years provided blood samples and answered a short questionnaire. The NHSIII was established in 2010 and includes participants of both male and female genders.
CountryUnited States
PubMed ID27459450
URLhttp://www.nurseshealthstudy.org/
Cohort designObservation

Publications with NHS (Nurses' Health Study)

TitleFirst authorYear
Alkylresorcinol metabolite concentrations in spot urine samples correlated with whole grain and cereal fiber intake but showed low to modest reproducibility over one to three years in U.S. womenLandberg2012
Validation of a food frequency questionnaire measurement of dietary acrylamide intake using hemoglobin adducts of acrylamide and glycidamideWilson2009
Comparison between plasma and erythrocyte fatty acid content as biomarkers of fatty acid intake in US womenSun2007
Associations of plasma carotenoid concentrations and dietary intake of specific carotenoids in samples of two prospective cohort studies using a new carotenoid databaseMichaud1998
The relation between dietary intake and adipose tissue composition of selected fatty acids in US womenGarland1998
Correlations of vitamin A and E intakes with the plasma concentrations of carotenoids and tocopherols among American men and womenAscherio1992
Reproducibility of plasma, red blood cell, and urine biomarkers among premenopausal and postmenopausal women from the Nurses' Health StudiesKotsopoulos2010
Within-person reproducibility of urinary bisphenol A and phthalate metabolites over a 1 to 3 year period among women in the Nurses’ Health Studies: a prospective cohort studyTownsend2013
Plasma carotenoids, retinol, and tocopherols and risk of breast cancerTamimi2005
Premenopausal plasma carotenoids, fluorescent oxidation products, and subsequent breast cancer risk in the nurses' health studiesSisti2015
Plasma carotenoids and risk of breast cancer over 20 y of follow-upEliassen2015
Circulating carotenoids, mammographic density, and subsequent risk of breast cancerTamimi2009
Plasma 25-Hydroxyvitamin D, Vitamin D Binding Protein, and Risk of Colorectal Cancer in the Nurses' Health StudySong2016
Plasma 25-Hydroxyvitamin D and Risk of Breast Cancer in Women Followed over 20 YearsEliassen2016
Plasma 25-hydroxyvitamin D and risk of breast cancer in the Nurses' Health Study IIEliassen2011
Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of breast cancerBertone-Johnson2005
Plasma vitamin D metabolites and risk of colorectal cancer in womenFeskanich2004
Plasma vitamin B6 and the risk of colorectal cancer and adenoma in womenWei2005
Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancerZhang2003
Pre-diagnostic plasma 25-hydroxyvitamin D levels and risk of non-melanoma skin cancer in womenLiang2012
Plasma enterolactone and breast cancer risk in the Nurses' Health Study IIXie2013
Plasma free 25-hydroxyvitamin D, vitamin D binding protein, and risk of breast cancer in the Nurses' Health Study IIWang2014

Biomarker data

Measurements of biomarkers in NHS (Nurses' Health Study)

Concentration values

IDParent IDDepthSubject groupPopulationCountryCohortBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianConverted unitAdjustment typeAdjusted onRegressed onExpressed asPublication

Reproducibility values

IDExcretion IDSubject groupPopulationCountryCohortBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication

Associations of biomarkers and exposures in NHS (Nurses' Health Study)

Correlation values

IDIntake IDExcretion IDSubject groupPopulationCountryCohortIntake Time definitionIntake Assessment methodIntakeIntake detailSupplement intakes included?Intake Arithmetic meanIntake Geometric meanIntake MedianIntake UnitIntake Adjusted onBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailBiomarker Arithmetic meanBiomarker Geometric meanBiomarker MedianBiomarker UnitBiomarker Adjusted onCorrelation sizeCorrelation typeCorrelation valueCorrelation 95% CI lowerCorrelation 95% CI upperCorrelation p-valueSignificant?Measurement adjustmentDeattenuated?CovariatesPublication

Metabolomic associations

IDIntake IDExcretion IDSubject groupPopulationCountryCohortNo. of subjectsIntake Assessment methodIntakeIntervention doseBiospecimenAnalytical methodBiomarkerStructural identificationFeature selectionArea under curveSensitivitySpecificityPLS-DA VIPBeta coefficientBeta coefficient p-valueANOVA p-valuePublication

Associations of biomarkers and cancer risk in NHS (Nurses' Health Study)

Cancer associations

IDExcretion IDSubject groupPopulationCountryCohortNo. of subjectsNo. of casesNo. of controlsBiospecimenAnalytical methodBiomarkerBiomarker detailCancerStudy designPublication

Exposure data

Measurements of exposures in NHS (Nurses' Health Study)

Intake values

IDParent IDDepthSubject groupPopulationCountryCohortIntake Time definitionIntake assessment toolIntake food coverageIntake time coverageIntake Assessment methodIntakeIntake detailFood descriptionSupplement intakes included?Measurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianConverted unitAdjustment typeAdjusted onRegressed onExpressed asPublication