Equol

ID10
NameEquol
Synonyms
StructureThumb
Description
GroupPolyphenols
Sub-groupIsoflavones
Exposure sourceDiet
Use
CAS number531-95-3
PubChem ID91469
ChEBI ID34741
FooDB IDFDB021824
HMDB IDHMDB02209

Biomarker measurements

Biomarker concentration values

IDParent IDDepthSubject groupPopulationCountryCountry codeCohortTime definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianAdjustment typeAdjusted onRegressed onExpressed asPublication
46492AllControls in a case-control study on prostate cancer inherited susceptibility and dietUnited KingdomGBPCANDIETSerum, non-fastingGC-ID-MS after enzymatic hydrolysisEquol1980.00.00.00.6759.32nmol/L0.0 nmol/LCrudeHeald 2006
72771Quartile 1 (Isoflavone intake: 0.06 to 3.67 mg/day)Pubertal girlsKorea, Republic ofKRUrine, overnightLC-MS after enzymatic hydrolysisEquol120.8nmol/mg0.8 umol/gDensityCreatinineKim 2010
81851Quartile 4 (Isoflavone intake: 9.29 to 51.59 mg/day)Pubertal girlsKorea, Republic ofKRUrine, overnightLC-MS after enzymatic hydrolysisEquol122.5nmol/mg2.5 umol/gDensityCreatinineKim 2010
1120AllWomen in a high-risk program for breast or ovarian cancerUnited StatesUSFRAP (Family Risk Assessment Program)Urine, 24-hGC-MS after enzymatic hydrolysisEquol27122.9425.22.312.829.1ng/mg122.9 ug/g12.8 ug/gDensityCreatinineTseng 2008
1170AllWomen in a high-risk program for breast or ovarian cancerUnited StatesUSFRAP (Family Risk Assessment Program)Urine, overnightGC-MS after enzymatic hydrolysisEquol2784.3274.17.210.020.9ng/mg84.3 ug/g10.0 ug/gDensityCreatinineTseng 2008
7157172AllGeneral adult populationUnited StatesUSNHANES 1999-2002Urine, spotLC-MS/MS after enzymatic hydrolysisEquol29082.10.1ng/mL0.0 mg/LCrudeChun 2009
7297302AllPremenopausal womenCanadaCAProspective study investigating risk factors for osteoporosisUrine, 24-hGC-MS after enzymatic hydrolysisEquol266.612.10.00.040.0umol/day6.6 umol/day0.0 umol/dayCrudeFrench 2007
252825211AllMidle-aged and elderly womenChinaCNSWHS (Shanghai Women's Health Study)Urine, spotLC-MS/MS after enzymatic hydrolysisEquol21650.060.00.00.0030.020.111.528.5618.21216.00.050.08nmol/mg0.1 umol/g0.1 umol/gDensityCreatinineWu 2012
480148121AllCases and controls in a case-control study on breast cancer and dietUnited KingdomGBEPIC-Norfolk (European Prospective Investigation into Cancer and Nutrition)Urine, spotGC-ID-MS after enzymatic hydrolysisEquol3330.52.10.00.10.7119.7ug/mmol500.0 ug/mol100.0 ug/molDensityCreatinineGrace 2004
480848141AllCases and controls in a case-control study on breast cancer and dietUnited KingdomGBEPIC-Norfolk (European Prospective Investigation into Cancer and Nutrition)Serum, unspecifiedLC-ID-MS/MS after enzymatic hydrolysisEquol2840.21.30.10.10.28.0ng/mL0.0 mg/L0.0 mg/LCrudeGrace 2004
694469452All [by intake]Members of the University of Minnesota communityUnited StatesUSUrine, 24-hGC-MS after enzymatic hydrolysisEquol980.251.020.080.080.09.36umol/day0.2 umol/day0.1 umol/dayCrudeLampe 1999
696469652High intake (Vegetables and fruits intake: ≥ 5 servings/day)Members of the University of Minnesota communityUnited StatesUSUrine, 24-hGC-MS after enzymatic hydrolysisEquol490.080.09umol/day0.1 umol/dayCrudeLampe 1999
697469752Low intake (Vegetables and fruits intake: ≤ 2 servings/day)Members of the University of Minnesota communityUnited StatesUSUrine, 24-hGC-MS after enzymatic hydrolysisEquol490.080.08umol/day0.1 umol/dayCrudeLampe 1999
71360Equol non-metabolizersMiddle-aged women from Tohoku regionJapanJPUrine, 24-hHPLC after enzymatic hydrolysisEquol530.0umol/day0.0 umol/dayCrudeArai 2000
71370Equol metabolizersMiddle-aged women from Tohoku regionJapanJPUrine, 24-hHPLC after enzymatic hydrolysisEquol5323.426.70.45.615.729.4123.6umol/day23.4 umol/day15.7 umol/dayCrudeArai 2000
781578101ChinesesWomen from two large mammography clinics in HonoluluUnited StatesUS1 dayUrine, overnightHPLC after enzymatic hydrolysisEquol1320.055.0nmol/h0.5 umol/dayCrudeMaskarinec 1998
782278171FilipinosWomen from two large mammography clinics in HonoluluUnited StatesUS1 dayUrine, overnightHPLC after enzymatic hydrolysisEquol70.0nmol/h0.0 umol/dayCrudeMaskarinec 1998
782978241Native HawaiiansWomen from two large mammography clinics in HonoluluUnited StatesUS1 dayUrine, overnightHPLC after enzymatic hydrolysisEquol117.023.0nmol/h0.2 umol/dayCrudeMaskarinec 1998
783678311JapanesesWomen from two large mammography clinics in HonoluluUnited StatesUS1 dayUrine, overnightHPLC after enzymatic hydrolysisEquol251.89.2nmol/h0.0 umol/dayCrudeMaskarinec 1998
784378381CaucasiansWomen from two large mammography clinics in HonoluluUnited StatesUS1 dayUrine, overnightHPLC after enzymatic hydrolysisEquol422.010.0nmol/h0.0 umol/dayCrudeMaskarinec 1998
785078451OthersWomen from two large mammography clinics in HonoluluUnited StatesUS1 dayUrine, overnightHPLC after enzymatic hydrolysisEquol49.017.0nmol/h0.2 umol/dayCrudeMaskarinec 1998
186450AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedLC-MS/MS after enzymatic hydrolysisEquol400.00.61.4nmol/L0.6 nmol/LCrudeKotsopoulos 2010
186530AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-MS/MS after enzymatic hydrolysisEquol450.010.040.29nmol/mg0.0 umol/gDensityCreatinineKotsopoulos 2010
18697186991AllMinority childrenUnited StatesUSbaseline; 2 weeks; 1 month; 2 months, 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisEquol3513.51.514.758.3249.5ug/g13.5 ug/g14.7 ug/gDensityCreatinineTeitelbaum 2008
189290AllWomenUnited StatesUSNYUWHS (New York University Women's Health Study)baseline; 1 year; 2 yearsSerum, unspecifiedGC-MS after enzymatic hydrolysisEquol600.2nmol/L0.2 nmol/LCrudeZeleniuch-Jacquotte 1998
189370AllWomenUnited StatesUSNYUWHS (New York University Women's Health Study)baselineSerum, unspecifiedGC-MS after enzymatic hydrolysisEquol6039.30.00.00.561.237.8nmol/L0.6 nmol/LCrudeZeleniuch-Jacquotte 1998
197750AllGirls from New York City, New York, Cincinnati, Ohio, and northern CaliforniaUnited StatesUSUrine, spotLC-MS/MS after enzymatic hydrolysisEquol9098.910.94.10.210.5485.0ug/L0.0 mg/L0.0 mg/LCrudeWolff 2007

Intake values

No data available

Correlation values

Reproducibility values

IDMst. IDSubject groupPopulationCountryCountry codeCohortTime definitionBiological specimenExperimental methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication
30118645AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedLC-MS/MS after enzymatic hydrolysisEquol0.6nmol/L400.053.50.0Kotsopoulos 2010
30518653AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-MS/MS after enzymatic hydrolysisEquol0.04nmol/mgCreatinine450.090.00.778.93.0Kotsopoulos 2010
35218697AllMinority childrenUnited StatesUSbaseline; 2 weeks; 1 month; 2 months, 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisEquol13.514.7ug/gCreatinine350.230.790.23Teitelbaum 2008
53418929AllWomenUnited StatesUSNYUWHS (New York University Women's Health Study)baseline; 1 year; 2 yearsSerum, unspecifiedGC-MS after enzymatic hydrolysisEquol0.2nmol/L600.30.140.460.2130.09Zeleniuch-Jacquotte 1998