Vitamin B12 (Compound)

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ID115
NameVitamin B12
SynonymsCobalamin; Cobalamins
StructureThumb
DescriptionIncludes all vitamers with vitamin B12 activity. Complexe mixture of several compounds.
ClassificationCompounds > Diet > Vitamins > Vitamin B > Vitamin B12 (Cobalamin)
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Publications with Vitamin B12

TitleFirst authorYear
Validity and reproducibility of folate and vitamin B(12) intakes estimated from a self-administered diet history questionnaire in Japanese pregnant womenShiraishi2012
Twenty-four hour urinary water-soluble vitamin levels correlate with their intakes in free-living Japanese schoolchildrenTsuji2011
Effect of cooking loss in the assessment of vitamin intake for epidemiological data in JapanKobayashi2011
Twenty-four-hour urinary water-soluble vitamin levels correlate with their intakes in free-living Japanese university studentsTsuji2010
Validity of food frequency questionnaire estimated intakes of folate and other B vitamins in a region without folic acid fortificationJohansson2010
Reliability and validity of food frequency questionnaire and nutrient biomarkers in elders with and without mild cognitive impairmentBowman2011
Urinary excretion of vitamin B1, B2, B6, niacin, pantothenic acid, folate, and vitamin C correlates with dietary intakes of free-living elderly, female JapaneseTsuji2010
Validation of a food choice map with a 3-day food record and serum values to assess folate and vitamin B-12 intake in college-aged womenShuaibi2008
Validation of the assessment of folate and vitamin B12 intake in women of reproductive age: the method of triadsVerkleij-Hagoort2007
Validation of a food frequency questionnaire to assess folate intake of Dutch elderly peoplevan de Rest2007
Relative validity of a food frequency questionnaire used in the Inter99 studyToft2008
Evaluating associations between Mediterranean diet adherence indexes and biomarkers of diet and diseaseBach-Faig2006
Application of the method of triads to evaluate the performance of food frequency questionnaires and biomarkers as indicators of long-term dietary intakeKabagambe2001
A three-day weighed food record and a semiquantitative food-frequency questionnaire are valid measures for assessing the folate and vitamin B-12 intakes of women aged 16 to 19 yearsGreen1998
Comparison of micronutrient intake measured by a dietary questionnaire and biochemical indicators of micronutrient statusJacques1993
Reliability of selected antioxidants and compounds involved in one-carbon metabolism in two Dutch cohortsLeenders2013
Intra- and inter-individual variations of blood and urinary water-soluble vitamins in Japanese young adults consuming a semi-purified diet for 7 daysShibata2009
A prospective study of one-carbon metabolism biomarkers and risk of renal cell carcinomaGibson2010
Prospective study of serum B vitamins levels and oesophageal and gastric cancers in ChinaRen2016
Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohortMatejcic2017
Plasma Riboflavin and Vitamin B-6, but Not Homocysteine, Folate, or Vitamin B-12, Are Inversely Associated with Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition-Varese CohortAgnoli2016
Alcohol consumption, one-carbon metabolites, liver cancer and liver disease mortalitySchwartz2013
Serum folate and vitamin B12 concentrations in relation to prostate cancer risk--a Norwegian population-based nested case-control study of 3000 cases and 3000 controls within the JANUS cohortde Vogel2013
A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and NutritionChuang2011
Serum B vitamin levels and risk of lung cancerJohansson2010
Plasma levels of B vitamins and colorectal cancer risk: the multiethnic cohort studyLe Marchand2009
One-carbon metabolism biomarkers and risk of colon and rectal cancersWeinstein2008
Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in womenLin2008
Circulating concentrations of folate and vitamin B12 in relation to prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition studyJohansson2008
The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and NutritionVollset2007
Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancerZhang2003
Null association between prostate cancer and serum folate, vitamin B(6), vitamin B(12), and homocysteineWeinstein2003
Association of the B-vitamins pyridoxal 5'-phosphate (B(6)), B(12), and folate with lung cancer risk in older menHartman2001
The risk of cervical cancer in relation to serum concentrations of folate, vitamin B12, and homocysteineAlberg2000
Pancreatic cancer risk and nutrition-related methyl-group availability indicators in male smokersStolzenberg-Solomon1999
Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective studyHultdin2005
Untangling the role of one-carbon metabolism in colorectal cancer risk: a comprehensive Bayesian network analysisMyte2017
Low folate levels are associated with reduced risk of colorectal cancer in a population with low folate statusGylling2014
Plasma vitamin B12 concentrations and the risk of colorectal cancer: a nested case-referent studyDahlin2008
A prospective study on folate, B12, and pyridoxal 5'-phosphate (B6) and breast cancerWu1999
Plasma vitamins B2, B6, and B12, and related genetic variants as predictors of colorectal cancer riskEussen2010
A prospective study of one-carbon metabolism biomarkers and cancer of the head and neck and esophagusFanidi2015
Low vitamin B12 increases risk of gastric cancer: A prospective study of one-carbon metabolism nutrients and risk of upper gastrointestinal tract cancerMiranti2017
Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survivalJohansson2014
Circulating Folate and Vitamin B12 and Risk of Prostate Cancer: A Collaborative Analysis of Individual Participant Data from Six Cohorts Including 6875 Cases and 8104 ControlsPrice2016
Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohortsSchernhammer2007
Plasma folate, vitamin B-6, and vitamin B-12 and breast cancer risk in BRCA1- and BRCA2-mutation carriers: a prospective studyKim2016

Biomarker data

Measurements of Vitamin B12 in biospecimens

Concentration values

IDParent IDDepthSubject groupPopulationCountryCohortBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianConverted unitAdjustment typeAdjusted onRegressed onExpressed asPublication

Reproducibility values

IDExcretion IDSubject groupPopulationCountryCohortBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication

Associations of Vitamin B12 with exposures

Correlation values

IDIntake IDExcretion IDSubject groupPopulationCountryCohortIntake Time definitionIntake Assessment methodIntakeIntake detailSupplement intakes included?Intake Arithmetic meanIntake Geometric meanIntake MedianIntake UnitIntake Adjusted onBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailBiomarker Arithmetic meanBiomarker Geometric meanBiomarker MedianBiomarker UnitBiomarker Adjusted onCorrelation sizeCorrelation typeCorrelation valueCorrelation 95% CI lowerCorrelation 95% CI upperCorrelation p-valueSignificant?Measurement adjustmentDeattenuated?CovariatesPublication

Metabolomic associations

IDIntake IDExcretion IDSubject groupPopulationCountryCohortNo. of subjectsIntake Assessment methodIntakeIntervention doseBiospecimenAnalytical methodBiomarkerStructural identificationFeature selectionArea under curveSensitivitySpecificityPLS-DA VIPBeta coefficientBeta coefficient p-valueANOVA p-valuePublication

Associations of Vitamin B12 with cancer risk

Cancer associations

IDExcretion IDSubject groupPopulationCountryCohortNo. of subjectsNo. of casesNo. of controlsBiospecimenAnalytical methodBiomarkerBiomarker detailCancerStudy designPublication

Exposure data

Measurements of Vitamin B12 exposures in populations

Intake values

IDParent IDDepthSubject groupPopulationCountryCohortIntake Time definitionIntake assessment toolIntake food coverageIntake time coverageIntake Assessment methodIntakeIntake detailFood descriptionSupplement intakes included?Measurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianConverted unitAdjustment typeAdjusted onRegressed onExpressed asPublication

Associations of Vitamin B12 exposures with biomarkers

Correlation values

IDIntake IDExcretion IDSubject groupPopulationCountryCohortIntake Time definitionIntake Assessment methodIntakeIntake detailSupplement intakes included?Intake Arithmetic meanIntake Geometric meanIntake MedianIntake UnitIntake Adjusted onBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailBiomarker Arithmetic meanBiomarker Geometric meanBiomarker MedianBiomarker UnitBiomarker Adjusted onCorrelation sizeCorrelation typeCorrelation valueCorrelation 95% CI lowerCorrelation 95% CI upperCorrelation p-valueSignificant?Measurement adjustmentDeattenuated?CovariatesPublication