Mono-isobutyl phthalate (MiBP)

ID1399
NameMono-isobutyl phthalate (MiBP)
SynonymsMono-iso-butyl phthalate
StructureThumb
DescriptionMetabolite of di-isobutyl phthalate (DiBP).
GroupPhthalates
Sub-groupPhthalate monoesters
Exposure sourcePollution
UsePlasticizers
CAS number30833-53-5
PubChem ID92272
ChEBI ID
FooDB IDFDB022820
HMDB IDHMDB02056

Biomarker measurements

Biomarker concentration values

IDParent IDDepthSubject groupPopulationCountryCountry codeCohortTime definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianAdjustment typeAdjusted onRegressed onExpressed asPublication
182340AllHmong womenUnited StatesUSFox River Environment and Diet Study cohort in Green Bay, Wisconsinbaseline; 15 days; 29.5 daysUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)45100.07.51.72.25.57.911.318.120.1ug/g7.5 ug/g7.9 ug/gDensityCreatininePeck 2010
186910AllMinority childrenUnited StatesUSbaseline; 2 weeks; 1 month; 2 months, 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)3516.52.115.650.9158.2ug/g16.5 ug/g15.6 ug/gDensityCreatinineTeitelbaum 2008
188110AllPregnant women living in the Northern karst area of Puerto RicoPuerto RicoPRPROTECT (Puerto Rico Testsite for Exploring Contamination Threats)baseline; 4 weeks; 8 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)139100.010.95.911.020.363.5964.09.812.1ng/mL0.0 mg/L0.0 mg/LCrudeCantonwine 2014
188930AllWomen seeking evaluation and treatment for infertility at the Massachusetts General HospitalUnited StatesUSEARTH (Environment and Reproductive Health)baseline; 12 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)1373.25.48.9ug/L0.0 mg/LDensitySpecific gravityBraun 2012
189010AllWomen seeking evaluation and treatment for infertility at the Massachusetts General HospitalUnited StatesUSEARTH (Environment and Reproductive Health)baseline; 15 weeks; 28 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)1374.05.99.0ug/L0.0 mg/LDensitySpecific gravityBraun 2012
18914205052AllWomenUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)403.60.93.512.0ng/mg3.6 ug/g3.5 ug/gDensityCreatinineTownsend 2013
192580AllChildren with and without asthma and/or allergiesDenmarkDKIECH (Danish Indoor Environment and Children’s Health)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)441100.0101.7200.069.52.119.342.572.2110.1251.0ng/mL0.1 mg/L0.1 mg/L0.1 mg/LCrudeLanger 2013
192890AllChildrenGermanyDEGerES IV (German Environmental Survey IV)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)59994.388.1223.0308.02050.089.299.7ug/L0.1 mg/L0.1 mg/LCrudeBecker 2009
193790AllPrimary school starters at the City of FrankfurtGermanyDEUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)111100.0122.074.98.465.1336.01405.088.9156.0ug/g122.0 ug/g74.9 ug/g65.1 ug/gDensityCreatinineKoch 2011
194300MalesEldersSwedenSEPIVUSSerum, fastingLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)5025013.229.5413.424.51390.0ng/mL0.0 mg/LCrudeOlsen 2012
194410FemalesEldersSwedenSEPIVUSSerum, fastingLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)5015012.79.0513.533.31820.0ng/mL0.0 mg/LCrudeOlsen 2012
19446194481ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)14571.014.025.039.058.084.0165.0474.0ug/g71.0 ug/g58.0 ug/gDensityCreatinineFrederiksen 2013
19463194651MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)14544.013.019.026.037.054.0100.0125.0ug/g44.0 ug/g37.0 ug/gDensityCreatinineFrederiksen 2013
19503195051ChildrenMother-child pairs in the industrialized city of DuisburgGermanyDEThe Duisburg birth cohort studyUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)104100.064.655.275.7ug/g64.6 ug/gDensityCreatinineKasper-Sonnenberg 2012
19530195321MothersMother-child pairs in the industrialized city of DuisburgGermanyDEThe Duisburg birth cohort studyUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)103100.037.231.843.5ug/g37.2 ug/gDensityCreatinineKasper-Sonnenberg 2012
195560AllPregnant women in two French regionsFranceFRELFE (Étude Longitudinale Francaise depuis l’Enfance)deliveryUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)279106.9145.77.868.7338.81471.8ug/g106.9 ug/g68.7 ug/gDensityCreatinineZeman 2013
195760AllMothers in southern SwedenSwedenSEUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)383421.021.01.115.023.0110.0ug/g21.0 ug/g15.0 ug/gDensityCreatinineHogberg 2008
195850AllMothers in southern SwedenSwedenSESerum, unspecifiedLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)3630.871.80.50.50.511.0ng/mL0.0 mg/L0.0 mg/LCrudeHogberg 2008
196120AllPregnant womenNorwayNOMoBa (Norwegian Mother and Child Cohort)Urine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)11074.25ug/g74.3 ug/gDensityCreatinineYe 2009
196280AllPregnant womenNetherlandsNLGeneration R studyUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)10096.4ug/g96.4 ug/gDensityCreatinineYe 2009
196420AllPregnant womenUnited StatesUSNHANESUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)1113.3ug/g3.3 ug/gDensityCreatinineYe 2009
196880UrbanUrban and rural premenstrual girlsEgyptEGUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)2868.617.62.533.2475.2ng/mL0.1 mg/L0.0 mg/LDensitySpecific gravityColacino 2011
197040RuralUrban and rural premenstrual girlsEgyptEGUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)2934.510.11.213.7232.2ng/mL0.0 mg/L0.0 mg/LDensitySpecific gravityColacino 2011
197160AllMinority pregnant women in New York cityUnited StatesUSCCCEH (Columbia Center for Children's Environmental Health)Urine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)246100.09.51.95.410.217.136.18.410.8ng/mL0.0 mg/L0.0 mg/LCrudeAdibi 2008
197480MalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)2347.721.025.049.775.177.7113.3ug/g47.7 ug/g49.7 ug/gDensityCreatinineFromme 2007
197580FemalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)2751.917.020.845.288.589.693.1ug/g51.9 ug/g45.2 ug/gDensityCreatinineFromme 2007
197840AllGirls from New York City, New York, Cincinnati, Ohio, and northern CaliforniaUnited StatesUSUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)9096.77.13.60.27.7144.0ug/L0.0 mg/L0.0 mg/LCrudeWolff 2007
198010AllStudents from 1988-2003GermanyDEESB (German Environmental Specimen Bank)Urine, 24-hLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)6346.735.4155.0901.0ug/g35.4 ug/gDensityCreatinineWittassek 2007
198700FemalesSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)9986.948.631.351.7102.0791.0ng/mL0.1 mg/L0.0 mg/L0.1 mg/LCrudeGuo 2011
198840MalesSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)84108.065.639.170.2144.0664.0ng/mL0.1 mg/L0.1 mg/L0.1 mg/LCrudeGuo 2011
198980AllSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)18357.6ug/g57.6 ug/gDensityCreatinineGuo 2011
199120ChineseSubjects from seven asian countriesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)4047.652.2ng/mL0.0 mg/L0.1 mg/LCrudeGuo 2011
199260IndianSubjects from seven asian countriesIndiaINUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)2218.919.1ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199400JapaneseSubjects from seven asian countriesJapanJPUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)355.55.9ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199540KuwaitiSubjects from seven asian countriesKuwaitKWUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)4635.531.2ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199680MalaysianSubjects from seven asian countriesMalaysiaMYUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)2916.615.2ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199820VietnameseSubjects from seven asian countriesViet NamVNUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)3012.210.3ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199960KoreanSubjects from seven asian countriesKorea, Republic ofKRUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)604.65.1ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
200180MothersPregnant women and their childrenTaiwanTWpregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)10018.42.4515.19165.014.7522.05ug/g18.4 ug/g15.2 ug/gDensityCreatinineLin 2011
200500Mothers providing milk samplesPregnant women and their childrenTaiwanTWBreast milkLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)291.10.50.681.78mg/L1.1 mg/L0.5 mg/LCrudeLin 2011
200610Children aged 5-6 yearsPregnant women and their childrenTaiwanTWUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)5957.054.1347.568.4ug/g57.0 ug/g54.1 ug/gDensityCreatinineLin 2011
200720Children aged 2-3 yearsPregnant women and their childrenTaiwanTWUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)3055.150.9740.075.9ug/g55.1 ug/g51.0 ug/gDensityCreatinineLin 2011
200830NewbornsPregnant women and their childrenTaiwanTWCord serumLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)301.13.440.681.78ug/L0.0 mg/L0.0 mg/LCrudeLin 2011
201890AllInfants from the Munich areaGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)25100.063.849.0152.0331.0ug/L0.1 mg/L0.0 mg/LCrudeFromme 2013
202130AllPregnant women in JerusalemIsraelILpregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)1918.027.752.7ug/g18.0 ug/g27.7 ug/gDensityCreatinineBerman 2009
202300MothersPregnant women and their childrenSpainESINMA (Environment and Childhood)pregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)11829.934.6ng/mL0.0 mg/LCrudeCasas 2011
202460ChildrenPregnant women and their childrenSpainESINMA (Environment and Childhood)Urine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)1941.967.3ng/mL0.0 mg/LCrudeCasas 2011
203150AllPregnant womenPeruPEbaseline; 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)7978.01.21.01.4ug/L0.0 mg/LCrudeIrvin 2010
203240AllPregnant womenPeruPEbaseline; 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)7879.02.62.32.9ug/g2.6 ug/gDensityCreatinineIrvin 2010
203360AllPregnant women from RotterdamNetherlandsNLGeneration R studypregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)100100.041.33.05.321.742.172.8759.0ug/L0.0 mg/L0.0 mg/LCrudeYe 2008
203520AllPregnant women from RotterdamNetherlandsNLGeneration R studypregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)10064.12.114.435.157.199.4640.0ug/g64.1 ug/g57.1 ug/gDensityCreatinineYe 2008
204640AllMothers from southern GermanyGermanyDEBAMBI (Bavarian Monitoring of Breast Milk study)delivery + 4 to 8 weeksBreast milkLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)74100.013.811.824.827.943.8ug/L0.0 mg/L0.0 mg/LCrudeFromme 2011
20499189162AllWomenUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)4016.14.215.654.0pmol/mg0.0 umol/g0.0 umol/gDensityCreatinineTownsend 2013

Intake values

No data available

Correlation values

No data available

Reproducibility values

IDMst. IDSubject groupPopulationCountryCountry codeCohortTime definitionBiological specimenExperimental methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication
10018234AllHmong womenUnited StatesUSFox River Environment and Diet Study cohort in Green Bay, Wisconsinbaseline; 15 days; 29.5 daysUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)7.57.9ug/gCreatinine450.510.480.54Peck 2010
34618691AllMinority childrenUnited StatesUSbaseline; 2 weeks; 1 month; 2 months, 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)16.515.6ug/gCreatinine350.280.340.14Teitelbaum 2008
43918811AllPregnant women living in the Northern karst area of Puerto RicoPuerto RicoPRPROTECT (Puerto Rico Testsite for Exploring Contamination Threats)baseline; 4 weeks; 8 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)10.911.0ng/mL1390.350.240.47Cantonwine 2014
45118827AllPregnant women living in the Northern karst area of Puerto RicoPuerto RicoPRPROTECT (Puerto Rico Testsite for Exploring Contamination Threats)baseline; 4 weeks; 8 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)ng/mLSpecific gravity1380.340.240.46Cantonwine 2014
49718893AllWomen seeking evaluation and treatment for infertility at the Massachusetts General HospitalUnited StatesUSEARTH (Environment and Reproductive Health)baseline; 12 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)5.4ug/LSpecific gravity1370.36Braun 2012
50518901AllWomen seeking evaluation and treatment for infertility at the Massachusetts General HospitalUnited StatesUSEARTH (Environment and Reproductive Health)baseline; 15 weeks; 28 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)5.9ug/LSpecific gravity1370.38Braun 2012
51920499AllWomenUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)16.115.6pmol/mgCreatinine400.30.10.620.720.31Townsend 2013
79819732Variability subgroupMinority pregnant women in New York cityUnited StatesUSCCCEH (Columbia Center for Children's Environmental Health)baseline; 2 weeks; 4 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)ng/mL280.54Adibi 2008
80219736AllAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)ug/gCreatinine500.44Fromme 2007