Mono(2-ethylhexyl) phthalate (MEHP)

ID1400
NameMono(2-ethylhexyl) phthalate (MEHP)
Synonyms
StructureThumb
DescriptionMetabolite of di(2-ethylhexyl) phthalate (DEHP).
GroupPhthalates
Sub-groupPhthalate monoesters
Exposure sourcePollution
UsePlasticizers
CAS number4376-20-9
PubChem ID20393
ChEBI ID17243
FooDB IDFDB029358
HMDB IDHMDB13248

Biomarker measurements

Biomarker concentration values

IDParent IDDepthSubject groupPopulationCountryCountry codeCohortTime definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianAdjustment typeAdjusted onRegressed onExpressed asPublication
18237205181AllHmong womenUnited StatesUSFox River Environment and Diet Study cohort in Green Bay, Wisconsinbaseline; 15 days; 29.5 daysUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)4581.03.42.40.02.33.59.121.336.0ug/g3.4 ug/g3.5 ug/gDensityCreatininePeck 2010
186730AllWomen in Washington DCUnited StatesUSA study to screen for uterine fibroids in 1996-1997baseline; 1 dayUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)4612.317.40.46.477.3ug/g12.3 ug/g6.4 ug/gDensityCreatinineHoppin 2002
18687186881AllMinority childrenUnited StatesUSbaseline; 2 weeks; 1 month; 2 months, 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)3511.30.511.790.2207.7ug/g11.3 ug/g11.7 ug/gDensityCreatinineTeitelbaum 2008
18733187421AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)33100.00.51.323.525.668.4622.4196.0ng/mL0.0 mg/LCrudeFrederiksen 2013
18749187581AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)33100.00.351.173.025.299.0517.451.2ng/mL0.0 mg/LCrudeFrederiksen 2013
18763187721AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)33100.00.91.563.485.498.3116.1232.0ng/mL0.0 mg/LCrudeFrederiksen 2013
188050AllPregnant women living in the Northern karst area of Puerto RicoPuerto RicoPRPROTECT (Puerto Rico Testsite for Exploring Contamination Threats)baseline; 4 weeks; 8 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)13992.93.31.63.77.417.5141.03.03.7ng/mL0.0 mg/L0.0 mg/LCrudeCantonwine 2014
18891188891AllWomen seeking evaluation and treatment for infertility at the Massachusetts General HospitalUnited StatesUSEARTH (Environment and Reproductive Health)baseline; 12 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)1372.85.07.7ug/L0.0 mg/LDensitySpecific gravityBraun 2012
18899188971AllWomen seeking evaluation and treatment for infertility at the Massachusetts General HospitalUnited StatesUSEARTH (Environment and Reproductive Health)baseline; 15 weeks; 28 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)1373.25.913.0ug/L0.0 mg/LDensitySpecific gravityBraun 2012
18918205062AllWomenUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)405.81.55.126.0ng/mg5.8 ug/g5.1 ug/gDensityCreatinineTownsend 2013
192600AllChildren with and without asthma and/or allergiesDenmarkDKIECH (Danish Indoor Environment and Children’s Health)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)44197.77.226.04.62.41.43.24.77.114.6ng/mL0.0 mg/L0.0 mg/L0.0 mg/LCrudeLanger 2013
192910AllChildrenGermanyDEGerES IV (German Environmental Survey IV)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)5996.46.716.225.1319.06.06.8ug/L0.0 mg/L0.0 mg/LCrudeBecker 2009
192990AllChildrenGermanyDEGerES IV (German Environmental Survey IV)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)2546.180.72.25.8517.423.7223.05.576.85ug/g6.2 ug/g5.9 ug/gDensityCreatinineBecker 2004
193020MalesChildrenGermanyDEGerES IV (German Environmental Survey IV)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)1149.31.228.8126.249.3103.07.9410.9ug/L0.0 mg/L0.0 mg/LCrudeBecker 2004
193050FemalesChildrenGermanyDEGerES IV (German Environmental Survey IV)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)1406.930.746.4120.023.4226.06.057.94ug/L0.0 mg/L0.0 mg/LCrudeBecker 2004
19353193501ChildrenNursery-school children and their teachers and parents in rural southern GermanyGermanyDEUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)361.78.727.548.4ug/g8.7 ug/gDensityCreatinineKoch 2004
19357193541AdultsNursery-school children and their teachers and parents in rural southern GermanyGermanyDEUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)193.88.624.726.6ug/g8.6 ug/gDensityCreatinineKoch 2004
193660AllDemographically diverse group of U.S. residentsUnited StatesUSUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)12935.00.00.00.02.320.4ng/mL0.0 mg/LCrudeKato 2004
193690AllDemographically diverse group of U.S. residentsUnited StatesUSUrine, spotLC-MS/MSMono(2-ethylhexyl) phthalate (MEHP)1291.00.00.00.00.00.0ng/mL0.0 mg/LCrudeKato 2004
193720AllDemographically diverse group of U.S. residentsUnited StatesUSSerum, unspecifiedLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)12988.03.90.02.84.05.915.2ng/mL0.0 mg/L0.0 mg/LCrudeKato 2004
193750AllDemographically diverse group of U.S. residentsUnited StatesUSSerum, unspecifiedLC-MS/MSMono(2-ethylhexyl) phthalate (MEHP)12984.02.50.02.22.83.45.0ng/mL0.0 mg/L0.0 mg/LCrudeKato 2004
193850AllPrimary school starters at the City of FrankfurtGermanyDEUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)11196.011.57.37.825.8153.08.414.6ug/g11.5 ug/g7.3 ug/g7.8 ug/gDensityCreatinineKoch 2011
19412189222AllWomenUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)4020.85.318.593.4pmol/mg0.0 umol/g0.0 umol/gDensityCreatinineTownsend 2013
194200AllAdultsUnited StatesUSNHANES IIIUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)2893.01.32.75.215.2192.0ug/g3.0 ug/g2.7 ug/gDensityCreatinineBlount 2000
194260MalesEldersSwedenSEPIVUSSerum, fastingLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)5025020.472.014.6914.5514.0ng/mL0.0 mg/LCrudeOlsen 2012
194370FemalesEldersSwedenSEPIVUSSerum, fastingLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)5015000.512.084.3317.4415.0ng/mL0.0 mg/LCrudeOlsen 2012
19450194541ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)1454.10.321.32.23.88.3175.0ug/g4.1 ug/g2.2 ug/gDensityCreatinineFrederiksen 2013
19467194711MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)1456.41.01.73.07.5571.0ug/g6.4 ug/g1.7 ug/gDensityCreatinineFrederiksen 2013
194870FemalesSubjects living in Central ItalyItalyITUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)8374.03.375.70.713.0313.811.854.89ug/g3.4 ug/g3.0 ug/gDensityCreatinineTranfo 2013
194920MalesSubjects living in Central ItalyItalyITUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)7474.02.86.910.393.112.971.084.52ug/g2.8 ug/g3.1 ug/gDensityCreatinineTranfo 2013
19508195131ChildrenMother-child pairs in the industrialized city of DuisburgGermanyDEThe Duisburg birth cohort studyUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)104100.03.83.34.4ug/g3.8 ug/gDensityCreatinineKasper-Sonnenberg 2012
19535195391MothersMother-child pairs in the industrialized city of DuisburgGermanyDEThe Duisburg birth cohort studyUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)103100.03.73.14.5ug/g3.7 ug/gDensityCreatinineKasper-Sonnenberg 2012
195500AllPregnant women in two French regionsFranceFRELFE (Étude Longitudinale Francaise depuis l’Enfance)deliveryUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)27968.4158.51.417.9229.01358.9ug/g68.4 ug/g17.9 ug/gDensityCreatinineZeman 2013
195720AllMothers in southern SwedenSwedenSEUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)383818.014.04.615.024.074.0ug/g18.0 ug/g15.0 ug/gDensityCreatinineHogberg 2008
195830AllMothers in southern SwedenSwedenSESerum, unspecifiedLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)3660.770.80.490.490.494.5ng/mL0.0 mg/L0.0 mg/LCrudeHogberg 2008
196010AllMothers in southern SwedenSwedenSEBreast milkLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)42161.31.30.490.491.76.5ng/mL0.0 mg/L0.0 mg/LCrudeHogberg 2008
196140AllPregnant womenNorwayNOMoBa (Norwegian Mother and Child Cohort)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)11029.59ug/g29.6 ug/gDensityCreatinineYe 2009
196300AllPregnant womenNetherlandsNLGeneration R studyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)10023.83ug/g23.8 ug/gDensityCreatinineYe 2009
196440AllPregnant womenUnited StatesUSNHANESUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)11110.41ug/g10.4 ug/gDensityCreatinineYe 2009
196830UrbanUrban and rural premenstrual girlsEgyptEGUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)2813.64.20.64.694.0ng/mL0.0 mg/L0.0 mg/LDensitySpecific gravityColacino 2011
196990RuralUrban and rural premenstrual girlsEgyptEGUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)295.41.30.43.129.6ng/mL0.0 mg/L0.0 mg/LDensitySpecific gravityColacino 2011
19707197112AllMinority pregnant women in New York cityUnited StatesUSCCCEH (Columbia Center for Children's Environmental Health)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)24685.04.80.52.24.813.646.84.05.8ng/mL0.0 mg/L0.0 mg/LCrudeAdibi 2008
19713197112AllMinority pregnant women in New York cityUnited StatesUSCCCEH (Columbia Center for Children's Environmental Health)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)24611.03.07.012.018.028.010.012.0percentRoot11.0 percentRoot12.0 percentRootCrudeAdibi 2008
19714197121AllMinority pregnant women in New York cityUnited StatesUSCCCEH (Columbia Center for Children's Environmental Health)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)2466.01.04.07.010.017.05.06.0percentRoot6.0 percentRoot7.0 percentRootCrudeAdibi 2008
197500MalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)234.41.42.44.36.57.17.5ug/g4.4 ug/g4.3 ug/gDensityCreatinineFromme 2007
197600FemalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)275.30.22.14.311.011.012.4ug/g5.3 ug/g4.3 ug/gDensityCreatinineFromme 2007
197700AllGeneral populationUnited StatesUSNHANES 1999-2000Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)254178.03.121.523.085.8810.818.52.923.35ug/g3.1 ug/g3.1 ug/gDensityCreatinineSilva 2004
197800AllGirls from New York City, New York, Cincinnati, Ohio, and northern CaliforniaUnited StatesUSUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)9094.43.33.00.63.2110.0ug/L0.0 mg/L0.0 mg/LCrudeWolff 2007
198090AllStudents from 1988-2003GermanyDEESB (German Environmental Specimen Bank)Urine, 24-hLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)6347.326.7108.0ug/g7.3 ug/gDensityCreatinineWittassek 2007
198770FemalesSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)995.94.21.76.856.9ng/mL0.0 mg/L0.0 mg/L0.0 mg/LCrudeGuo 2011
198910MalesSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)8411.36.12.25.4207.0ng/mL0.0 mg/L0.0 mg/L0.0 mg/LCrudeGuo 2011
199050AllSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)1831.8ug/g1.8 ug/gDensityCreatinineGuo 2011
199190ChineseSubjects from seven asian countriesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)403.0ng/mL0.0 mg/LCrudeGuo 2011
199330IndianSubjects from seven asian countriesIndiaINUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)223.41.6ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199470JapaneseSubjects from seven asian countriesJapanJPUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)351.71.3ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199610KuwaitiSubjects from seven asian countriesKuwaitKWUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)464.64.1ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199750MalaysianSubjects from seven asian countriesMalaysiaMYUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)294.72.5ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199890VietnameseSubjects from seven asian countriesViet NamVNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)302.41.7ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
200030KoreanSubjects from seven asian countriesKorea, Republic ofKRUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)604.01.2ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
200080AllInhabitants of Erlangen and surroundingsGermanyDEUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)8512.414.69.234.7123.0ug/g12.4 ug/g9.2 ug/gDensityCreatinineKoch 2003
200130MothersPregnant women and their childrenTaiwanTWpregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)10017.340.3816.37353.914.0721.36ug/g17.3 ug/g16.4 ug/gDensityCreatinineLin 2011
200450Mothers providing milk samplesPregnant women and their childrenTaiwanTWBreast milkLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)292.493.61.254.98mg/L2.5 mg/L3.6 mg/LCrudeLin 2011
200560Children aged 5-6 yearsPregnant women and their childrenTaiwanTWUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)5922.7321.3718.228.4mg/L22.7 mg/L21.4 mg/LDensityCreatinineLin 2011
200670Children aged 2-3 yearsPregnant women and their childrenTaiwanTWUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)3027.521.0418.540.9ug/g27.5 ug/g21.0 ug/gDensityCreatinineLin 2011
200780NewbornsPregnant women and their childrenTaiwanTWCord serumLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)302.493.021.254.98ug/L0.0 mg/L0.0 mg/LCrudeLin 2011
201420AllGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)32363.61.63.57.124.93.24.0ug/L0.0 mg/L0.0 mg/LCrudeSaravanabhavan 2013
201500MalesGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)16304.11.93.97.925.83.54.6ug/L0.0 mg/L0.0 mg/LCrudeSaravanabhavan 2013
201640AllGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)32364.02.13.66.922.33.54.5ug/g4.0 ug/g3.6 ug/gDensityCreatinineSaravanabhavan 2013
201710MalesGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)16303.82.03.56.521.33.34.3ug/g3.8 ug/g3.5 ug/gDensityCreatinineSaravanabhavan 2013
201780ChildrenGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)10373.31.63.36.417.82.93.7ug/L0.0 mg/L0.0 mg/LCrudeSaravanabhavan 2013
201940AllInfants from the Munich areaGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)2599.02.62.16.120.7ug/L0.0 mg/L0.0 mg/LCrudeFromme 2013
202170AllPregnant women in JerusalemIsraelILpregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)196.57.040.8ug/g6.5 ug/g7.0 ug/gDensityCreatinineBerman 2009
202280MothersPregnant women and their childrenSpainESINMA (Environment and Childhood)pregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)1184.46.8ng/mL0.0 mg/LCrudeCasas 2011
202440ChildrenPregnant women and their childrenSpainESINMA (Environment and Childhood)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)196.26.7ng/mL0.0 mg/LCrudeCasas 2011
202540AllOffice workersTaiwanTWUrine, spotGC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)6093.013.33.38.115.930.345.056.2ng/mL0.0 mg/L0.0 mg/LCrudeChen 2008
203210AllPregnant womenPeruPEbaseline; 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)7947.01.61.41.8ug/L0.0 mg/LCrudeIrvin 2010
203380AllPregnant women from RotterdamNetherlandsNLGeneration R studypregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)10096.06.92.73.36.917.3392.0ug/L0.0 mg/L0.0 mg/LCrudeYe 2008
203540AllPregnant women from RotterdamNetherlandsNLGeneration R studypregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)10010.82.16.99.920.9321.0ug/g10.8 ug/g9.9 ug/gDensityCreatinineYe 2008
204090AllCouples seeking infertility evaluation and treatment at the Massachusetts General Hospital Fertility CenterUnited StatesUSbaseline; 35 days; 70 daysUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)2695.31.74.814.349.5107.01710.0ng/mL0.0 mg/L0.0 mg/LCrudeMeeker 2012
204660AllMothers from southern GermanyGermanyDEBAMBI (Bavarian Monitoring of Breast Milk study)delivery + 4 to 8 weeksBreast milkLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)7458.03.02.36.610.327.4ug/L0.0 mg/L0.0 mg/LCrudeFromme 2011
204740AllResidents of the Tokyo-Yokohama areaJapanJPUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)365.0ug/L0.0 mg/LCrudeItoh 2007
204760AllWomenUnited StatesUSbaseline; 1 day; 28 days; 29 days; 30 days; 31 days; 32 days; 33 days; 34 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)109.411.2115.0ng/mL0.0 mg/LCrudeMarcus 2010
204810AllWomenUnited StatesUSbaseline; 1 day; 28 days; 29 days; 30 days; 31 days; 32 days; 33 days; 34 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)1011.013.2201.0ug/g11.0 ug/gDensityCreatinineMarcus 2010

Intake values

No data available

Correlation values

No data available

Reproducibility values

IDMst. IDSubject groupPopulationCountryCountry codeCohortTime definitionBiological specimenExperimental methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication
10318237AllHmong womenUnited StatesUSFox River Environment and Diet Study cohort in Green Bay, Wisconsinbaseline; 15 days; 29.5 daysUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)3.43.5ug/gCreatinine450.220.00.38Peck 2010
31518673AllWomen in Washington DCUnited StatesUSA study to screen for uterine fibroids in 1996-1997baseline; 1 dayUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)12.36.4ug/gCreatinine460.670.490.79Hoppin 2002
34218687AllMinority childrenUnited StatesUSbaseline; 2 weeks; 1 month; 2 months, 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)11.311.7ug/gCreatinine350.290.930.38Teitelbaum 2008
38618733AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)5.66ng/mL330.210.00.450.6080.157Frederiksen 2013
39618763AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)5.49ng/mL330.190.00.430.4770.114Frederiksen 2013
39918749AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)5.29ng/mL330.370.030.630.4580.265Frederiksen 2013
43318805AllPregnant women living in the Northern karst area of Puerto RicoPuerto RicoPRPROTECT (Puerto Rico Testsite for Exploring Contamination Threats)baseline; 4 weeks; 8 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)3.33.7ng/mL1390.350.240.47Cantonwine 2014
44518821AllPregnant women living in the Northern karst area of Puerto RicoPuerto RicoPRPROTECT (Puerto Rico Testsite for Exploring Contamination Threats)baseline; 4 weeks; 8 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)ng/mLSpecific gravity1380.360.260.48Cantonwine 2014
49518891AllWomen seeking evaluation and treatment for infertility at the Massachusetts General HospitalUnited StatesUSEARTH (Environment and Reproductive Health)baseline; 12 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)5.0ug/LSpecific gravity1370.11Braun 2012
50318899AllWomen seeking evaluation and treatment for infertility at the Massachusetts General HospitalUnited StatesUSEARTH (Environment and Reproductive Health)baseline; 15 weeks; 28 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)5.9ug/LSpecific gravity1370.08Braun 2012
52319412AllWomenUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)20.818.5pmol/mgCreatinine400.140.010.670.930.15Townsend 2013
79119723Variability subgroupMinority pregnant women in New York cityUnited StatesUSCCCEH (Columbia Center for Children's Environmental Health)baseline; 2 weeks; 4 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)ng/mL280.35Adibi 2008
79519729Variability subgroupMinority pregnant women in New York cityUnited StatesUSCCCEH (Columbia Center for Children's Environmental Health)baseline; 2 weeks; 4 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)percentRoot280.64Adibi 2008
79619730Variability subgroupMinority pregnant women in New York cityUnited StatesUSCCCEH (Columbia Center for Children's Environmental Health)baseline; 2 weeks; 4 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)percentRoot280.6Adibi 2008
80419738AllAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)ug/gCreatinine500.34Fromme 2007
86920409AllCouples seeking infertility evaluation and treatment at the Massachusetts General Hospital Fertility CenterUnited StatesUSbaseline; 35 days; 70 daysUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)5.34.8ng/mL2690.130.080.22Meeker 2012
89320476AllWomenUnited StatesUSbaseline; 1 day; 28 days; 29 days; 30 days; 31 days; 32 days; 33 days; 34 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)9.4ng/mL100.58Marcus 2010