Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)

ID1401
NameMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Synonyms5-oxo-MEHP
StructureThumb
DescriptionMetabolite of mono(2-ethylhexyl) phthalate (MEHP); secondary metabolite of di(2-ethylhexyl) phthalate (DEHP).
GroupPhthalates
Sub-groupPhthalate monoesters
Exposure sourcePollution
UsePlasticizers
CAS number40321-98-0
PubChem ID119096
ChEBI ID
FooDB ID
HMDB ID

Biomarker measurements

Biomarker concentration values

IDParent IDDepthSubject groupPopulationCountryCountry codeCohortTime definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianAdjustment typeAdjusted onRegressed onExpressed asPublication
18240205181AllHmong womenUnited StatesUSFox River Environment and Diet Study cohort in Green Bay, Wisconsinbaseline; 15 days; 29.5 daysUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)45100.013.02.13.17.613.425.383.1103.9ug/g13.0 ug/g13.4 ug/gDensityCreatininePeck 2010
18686186881AllMinority childrenUnited StatesUSbaseline; 2 weeks; 1 month; 2 months, 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)3553.94.650.9350.4710.4ug/g53.9 ug/g50.9 ug/gDensityCreatinineTeitelbaum 2008
18735187421AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)33100.02.427.5713.421.931.467.3848.0ng/mL0.0 mg/LCrudeFrederiksen 2013
18751187581AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)33100.00.432.5610.116.722.161.0101.0ng/mL0.0 mg/LCrudeFrederiksen 2013
18765187721AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)33100.03.575.1910.916.922.544.4634.0ng/mL0.0 mg/LCrudeFrederiksen 2013
188070AllPregnant women living in the Northern karst area of Puerto RicoPuerto RicoPRPROTECT (Puerto Rico Testsite for Exploring Contamination Threats)baseline; 4 weeks; 8 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)139100.08.95.29.317.335.3281.08.19.9ng/mL0.0 mg/L0.0 mg/LCrudeCantonwine 2014
18920205062AllWomenUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)4030.77.425.6136.2ng/mg30.7 ug/g25.6 ug/gDensityCreatinineTownsend 2013
192620AllChildren with and without asthma and/or allergiesDenmarkDKIECH (Danish Indoor Environment and Children’s Health)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)44184.429.4102.016.22.72.910.017.630.371.3ng/mL0.0 mg/L0.0 mg/L0.0 mg/LCrudeLanger 2013
192930AllChildrenGermanyDEGerES IV (German Environmental Survey IV)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)59937.036.387.5123.02490.034.939.1ug/L0.0 mg/L0.0 mg/LCrudeBecker 2009
193010AllChildrenGermanyDEGerES IV (German Environmental Survey IV)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)25431.23.8311.330.581.2119.01090.028.334.5ug/g31.2 ug/g30.5 ug/gDensityCreatinineBecker 2004
193040MalesChildrenGermanyDEGerES IV (German Environmental Survey IV)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)11444.46.9445.0126.0167.01420.037.951.8ug/L0.0 mg/L0.0 mg/LCrudeBecker 2004
193070FemalesChildrenGermanyDEGerES IV (German Environmental Survey IV)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)14036.60.039.579.7122.0352.032.042.0ug/L0.0 mg/L0.0 mg/LCrudeBecker 2004
19352193501ChildrenNursery-school children and their teachers and parents in rural southern GermanyGermanyDEUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)3610.238.375.8158.0ug/g38.3 ug/gDensityCreatinineKoch 2004
19356193541AdultsNursery-school children and their teachers and parents in rural southern GermanyGermanyDEUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)194.517.234.740.9ug/g17.2 ug/gDensityCreatinineKoch 2004
193670AllDemographically diverse group of U.S. residentsUnited StatesUSUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)12991.014.80.05.115.640.1243.0ng/mL0.0 mg/L0.0 mg/LCrudeKato 2004
193700AllDemographically diverse group of U.S. residentsUnited StatesUSUrine, spotLC-MS/MSMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)12962.05.60.01.33.99.648.8ng/mL0.0 mg/L0.0 mg/LCrudeKato 2004
193730AllDemographically diverse group of U.S. residentsUnited StatesUSSerum, unspecifiedLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)12918.00.00.00.00.03.4ng/mL0.0 mg/LCrudeKato 2004
193760AllDemographically diverse group of U.S. residentsUnited StatesUSSerum, unspecifiedLC-MS/MSMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)1293.00.00.00.00.00.0ng/mL0.0 mg/LCrudeKato 2004
193820AllPrimary school starters at the City of FrankfurtGermanyDEUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)111100.034.224.33.724.397.2205.027.840.6ug/g34.2 ug/g24.3 ug/g24.3 ug/gDensityCreatinineKoch 2011
19414189222AllWomenUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)40105.025.387.7466.5pmol/mg0.1 umol/g0.1 umol/gDensityCreatinineTownsend 2013
19452194541ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)14515.01.54.97.911.017.033.0204.0ug/g15.0 ug/g11.0 ug/gDensityCreatinineFrederiksen 2013
19469194711MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)14510.02.43.96.28.619.0321.0ug/g10.0 ug/g6.2 ug/gDensityCreatinineFrederiksen 2013
19510195131ChildrenMother-child pairs in the industrialized city of DuisburgGermanyDEThe Duisburg birth cohort studyUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)104100.025.622.828.8ug/g25.6 ug/gDensityCreatinineKasper-Sonnenberg 2012
19537195391MothersMother-child pairs in the industrialized city of DuisburgGermanyDEThe Duisburg birth cohort studyUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)103100.010.08.711.5ug/g10.0 ug/gDensityCreatinineKasper-Sonnenberg 2012
195520AllPregnant women in two French regionsFranceFRELFE (Étude Longitudinale Francaise depuis l’Enfance)deliveryUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)279122.0221.32.032.9510.21525.0ug/g122.0 ug/g32.9 ug/gDensityCreatinineZeman 2013
195730AllMothers in southern SwedenSwedenSEUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)383718.013.03.015.024.057.0ug/g18.0 ug/g15.0 ug/gDensityCreatinineHogberg 2008
196160AllPregnant womenNorwayNOMoBa (Norwegian Mother and Child Cohort)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)11028.49ug/g28.5 ug/gDensityCreatinineYe 2009
196320AllPregnant womenNetherlandsNLGeneration R studyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)10034.62ug/g34.6 ug/gDensityCreatinineYe 2009
196460AllPregnant womenUnited StatesUSNHANESUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)11117.82ug/g17.8 ug/gDensityCreatinineYe 2009
196870UrbanUrban and rural premenstrual girlsEgyptEGUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)2854.614.40.921.7257.8ng/mL0.1 mg/L0.0 mg/LDensitySpecific gravityColacino 2011
197030RuralUrban and rural premenstrual girlsEgyptEGUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)2920.92.91.214.452.8ng/mL0.0 mg/L0.0 mg/LDensitySpecific gravityColacino 2011
19708197112AllMinority pregnant women in New York cityUnited StatesUSCCCEH (Columbia Center for Children's Environmental Health)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)246100.018.22.89.417.533.6107.615.621.3ng/mL0.0 mg/L0.0 mg/LCrudeAdibi 2008
197510MalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)2312.36.78.412.116.118.620.3ug/g12.3 ug/g12.1 ug/gDensityCreatinineFromme 2007
197610FemalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)2716.75.48.514.926.242.246.8ug/g16.7 ug/g14.9 ug/gDensityCreatinineFromme 2007
197790AllGirls from New York City, New York, Cincinnati, Ohio, and northern CaliforniaUnited StatesUSUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)90100.018.83.31.317.81070.0ug/L0.0 mg/L0.0 mg/LCrudeWolff 2007
198060AllStudents from 1988-2003GermanyDEESB (German Environmental Specimen Bank)Urine, 24-hLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)6342.716.151.7251.0ug/g16.1 ug/gDensityCreatinineWittassek 2007
198740FemalesSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)9912.38.00.24.67.313.4111.0ng/mL0.0 mg/L0.0 mg/L0.0 mg/LCrudeGuo 2011
198880MalesSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)8422.08.00.34.26.913.1564.0ng/mL0.0 mg/L0.0 mg/L0.0 mg/LCrudeGuo 2011
199020AllSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)1836.8ug/g6.8 ug/gDensityCreatinineGuo 2011
199160ChineseSubjects from seven asian countriesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)405.24.7ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199300IndianSubjects from seven asian countriesIndiaINUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)2211.211.2ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199440JapaneseSubjects from seven asian countriesJapanJPUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)352.93.0ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199580KuwaitiSubjects from seven asian countriesKuwaitKWUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)4610.912.5ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199720MalaysianSubjects from seven asian countriesMalaysiaMYUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)296.45.5ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199860VietnameseSubjects from seven asian countriesViet NamVNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)304.34.1ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
200000KoreanSubjects from seven asian countriesKorea, Republic ofKRUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)603.94.9ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
200070AllInhabitants of Erlangen and surroundingsGermanyDEUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)8541.741.46.430.4106.0262.0ug/g41.7 ug/g30.4 ug/gDensityCreatinineKoch 2003
200150MothersPregnant women and their childrenTaiwanTWpregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)10036.978.0629.52663.030.9144.22ug/g37.0 ug/g29.5 ug/gDensityCreatinineLin 2011
200470Mothers providing milk samplesPregnant women and their childrenTaiwanTWBreast milkLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)290.260.240.26mg/L0.3 mg/LCrudeLin 2011
200580Children aged 5-6 yearsPregnant women and their childrenTaiwanTWUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)5963.958.7151.179.9mg/L63.9 mg/L58.7 mg/LDensityCreatinineLin 2011
200690Children aged 2-3 yearsPregnant women and their childrenTaiwanTWUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)30116.3114.3378.9171.6ug/g116.3 ug/g114.3 ug/gDensityCreatinineLin 2011
201430AllGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)323614.26.814.029.0113.812.715.6ug/L0.0 mg/L0.0 mg/LCrudeSaravanabhavan 2013
201510MalesGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)163014.97.114.429.5109.612.916.9ug/L0.0 mg/L0.0 mg/LCrudeSaravanabhavan 2013
201650AllGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)323615.78.414.125.296.714.217.3ug/g15.7 ug/g14.1 ug/gDensityCreatinineSaravanabhavan 2013
201720MalesGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)163013.97.312.522.184.712.515.4ug/g13.9 ug/g12.5 ug/gDensityCreatinineSaravanabhavan 2013
201790ChildrenGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)103719.910.420.338.4106.717.522.2ug/L0.0 mg/L0.0 mg/LCrudeSaravanabhavan 2013
201950AllInfants from the Munich areaGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)2597.019.413.958.0126.0ug/L0.0 mg/L0.0 mg/LCrudeFromme 2013
202160AllPregnant women in JerusalemIsraelILpregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)1920.15.017.5129.4ug/g20.1 ug/g17.5 ug/gDensityCreatinineBerman 2009
202270MothersPregnant women and their childrenSpainESINMA (Environment and Childhood)pregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)11815.719.3ng/mL0.0 mg/LCrudeCasas 2011
202430ChildrenPregnant women and their childrenSpainESINMA (Environment and Childhood)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)1944.646.7ng/mL0.0 mg/LCrudeCasas 2011
203200AllPregnant womenPeruPEbaseline; 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)7987.03.12.63.7ug/L0.0 mg/LCrudeIrvin 2010
203290AllPregnant womenPeruPEbaseline; 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)7888.06.75.97.7ug/g6.7 ug/gDensityCreatinineIrvin 2010
203400AllPregnant women from RotterdamNetherlandsNLGeneration R studypregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)100100.015.02.60.77.214.527.4514.0ug/L0.0 mg/L0.0 mg/LCrudeYe 2008
203560AllPregnant women from RotterdamNetherlandsNLGeneration R studypregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)10023.32.05.315.620.930.7386.0ug/g23.3 ug/g20.9 ug/gDensityCreatinineYe 2008
203960AllCouples seeking infertility evaluation and treatment at the Massachusetts General Hospital Fertility CenterUnited StatesUSbaseline; 35 days; 70 daysUrine, spotLC-ID-MS/MSMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)2691.71.64.019.3148.0ng/mL0.0 mg/L0.0 mg/LCrudeMeeker 2012
204030AllCouples seeking infertility evaluation and treatment at the Massachusetts General Hospital Fertility CenterUnited StatesUSbaseline; 35 days; 70 daysUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)26921.02.76.921.062.1174.0314.03410.0ng/mL0.0 mg/L0.0 mg/LCrudeMeeker 2012

Intake values

No data available

Correlation values

No data available

Reproducibility values

IDMst. IDSubject groupPopulationCountryCountry codeCohortTime definitionBiological specimenExperimental methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication
10618240AllHmong womenUnited StatesUSFox River Environment and Diet Study cohort in Green Bay, Wisconsinbaseline; 15 days; 29.5 daysUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)13.013.4ug/gCreatinine450.190.00.33Peck 2010
34118686AllMinority childrenUnited StatesUSbaseline; 2 weeks; 1 month; 2 months, 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)53.950.9ug/gCreatinine350.230.770.23Teitelbaum 2008
43518807AllPregnant women living in the Northern karst area of Puerto RicoPuerto RicoPRPROTECT (Puerto Rico Testsite for Exploring Contamination Threats)baseline; 4 weeks; 8 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)8.99.3ng/mL1390.260.160.39Cantonwine 2014
44718823AllPregnant women living in the Northern karst area of Puerto RicoPuerto RicoPRPROTECT (Puerto Rico Testsite for Exploring Contamination Threats)baseline; 4 weeks; 8 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)ng/mLSpecific gravity1380.250.150.38Cantonwine 2014
52519414AllWomenUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)105.087.7pmol/mgCreatinine400.420.20.670.620.44Townsend 2013
79219724Variability subgroupMinority pregnant women in New York cityUnited StatesUSCCCEH (Columbia Center for Children's Environmental Health)baseline; 2 weeks; 4 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)ng/mL280.34Adibi 2008
80519739AllAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)ug/gCreatinine500.24Fromme 2007
85620396AllCouples seeking infertility evaluation and treatment at the Massachusetts General Hospital Fertility CenterUnited StatesUSbaseline; 35 days; 70 daysUrine, spotLC-ID-MS/MSMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)1.71.6ng/mL2690.10.050.17Meeker 2012
86320403AllCouples seeking infertility evaluation and treatment at the Massachusetts General Hospital Fertility CenterUnited StatesUSbaseline; 35 days; 70 daysUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)21.021.0ng/mL2690.140.090.21Meeker 2012