Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)

ID1402
NameMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Synonyms5-OH-MEHP
StructureThumb
DescriptionMetabolite of mono(2-ethylhexyl) phthalate (MEHP); secondary metabolite of di(2-ethylhexyl) phthalate (DEHP).
GroupPhthalates
Sub-groupPhthalate monoesters
Exposure sourcePollution
UsePlasticizers
CAS number40321-99-1
PubChem ID170295
ChEBI ID
FooDB ID
HMDB ID

Biomarker measurements

Biomarker concentration values

IDParent IDDepthSubject groupPopulationCountryCountry codeCohortTime definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianAdjustment typeAdjusted onRegressed onExpressed asPublication
18239205181AllHmong womenUnited StatesUSFox River Environment and Diet Study cohort in Green Bay, Wisconsinbaseline; 15 days; 29.5 daysUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)45100.019.52.23.910.720.336.8138.4251.3ug/g19.5 ug/g20.3 ug/gDensityCreatininePeck 2010
18685186881AllMinority childrenUnited StatesUSbaseline; 2 weeks; 1 month; 2 months, 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)3584.86.476.4592.11101.0ug/g84.8 ug/g76.4 ug/gDensityCreatinineTeitelbaum 2008
18734187421AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)33100.03.4910.321.432.645.8107.0867.0ng/mL0.0 mg/LCrudeFrederiksen 2013
18750187581AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)33100.00.923.3312.723.731.792.8178.0ng/mL0.0 mg/LCrudeFrederiksen 2013
18764187721AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)33100.04.667.5215.725.336.671.7688.0ng/mL0.0 mg/LCrudeFrederiksen 2013
188060AllPregnant women living in the Northern karst area of Puerto RicoPuerto RicoPRPROTECT (Puerto Rico Testsite for Exploring Contamination Threats)baseline; 4 weeks; 8 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)139100.010.76.111.520.646.3361.09.711.8ng/mL0.0 mg/L0.0 mg/LCrudeCantonwine 2014
189060AllSubjects in the metropolitan Atlanta area non-occupationally exposed to phthalatesUnited StatesUSbaseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)837.615.529.876.2ug/g37.6 ug/g29.8 ug/gDensityCreatininePreau 2010
189080AllSubjects in the metropolitan Atlanta area non-occupationally exposed to phthalatesUnited StatesUSbaseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)833.618.428.0555.4ug/g33.6 ug/g28.1 ug/gDensityCreatininePreau 2010
189100AllSubjects in the metropolitan Atlanta area non-occupationally exposed to phthalatesUnited StatesUSbaseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)855.921.844.7163.0ug/g55.9 ug/g44.7 ug/gDensityCreatininePreau 2010
18919205062AllWomenUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)4035.78.731.7162.8ng/mg35.7 ug/g31.7 ug/gDensityCreatinineTownsend 2013
192610AllChildren with and without asthma and/or allergiesDenmarkDKIECH (Danish Indoor Environment and Children’s Health)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)441100.050.7129.032.42.48.120.333.251.8115.9ng/mL0.1 mg/L0.0 mg/L0.0 mg/LCrudeLanger 2013
192920AllChildrenGermanyDEGerES IV (German Environmental Survey IV)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)59947.946.0110.0164.03640.045.150.8ug/L0.0 mg/L0.0 mg/LCrudeBecker 2009
193000AllChildrenGermanyDEGerES IV (German Environmental Survey IV)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)25440.74.814.739.9103.0170.01990.036.845.1ug/g40.7 ug/g39.9 ug/gDensityCreatinineBecker 2004
193030MalesChildrenGermanyDEGerES IV (German Environmental Survey IV)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)11457.56.6556.9169.0227.02590.048.967.6ug/L0.1 mg/L0.1 mg/LCrudeBecker 2004
193060FemalesChildrenGermanyDEGerES IV (German Environmental Survey IV)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)14048.21.8650.6117.0151.0597.042.454.7ug/L0.0 mg/L0.1 mg/LCrudeBecker 2004
19351193501ChildrenNursery-school children and their teachers and parents in rural southern GermanyGermanyDEUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)3615.455.8113.0258.0ug/g55.8 ug/gDensityCreatinineKoch 2004
19355193541AdultsNursery-school children and their teachers and parents in rural southern GermanyGermanyDEUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)1910.928.148.063.6ug/g28.1 ug/gDensityCreatinineKoch 2004
193680AllDemographically diverse group of U.S. residentsUnited StatesUSUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)12995.019.30.08.817.441.1220.0ng/mL0.0 mg/L0.0 mg/LCrudeKato 2004
193710AllDemographically diverse group of U.S. residentsUnited StatesUSUrine, spotLC-MS/MSMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)12938.00.00.00.00.00.05.8ng/mL0.0 mg/LCrudeKato 2004
193740AllDemographically diverse group of U.S. residentsUnited StatesUSSerum, unspecifiedLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)12944.00.00.00.00.03.1ng/mL0.0 mg/LCrudeKato 2004
193770AllDemographically diverse group of U.S. residentsUnited StatesUSSerum, unspecifiedLC-MS/MSMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)1294.00.00.00.00.00.0ng/mL0.0 mg/LCrudeKato 2004
193810AllPrimary school starters at the City of FrankfurtGermanyDEUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)111100.041.229.24.528.0104.0290.032.849.6ug/g41.2 ug/g29.2 ug/g28.0 ug/gDensityCreatinineKoch 2011
19413189222AllWomenUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)40121.329.5107.9553.8pmol/mg0.1 umol/g0.1 umol/gDensityCreatinineTownsend 2013
19451194541ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)14531.03.711.016.022.035.070.0275.0ug/g31.0 ug/g22.0 ug/gDensityCreatinineFrederiksen 2013
19468194711MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)14521.03.04.89.813.018.043.0647.0ug/g21.0 ug/g13.0 ug/gDensityCreatinineFrederiksen 2013
194880FemalesSubjects living in Central ItalyItalyITUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)83100.012.7415.293.0214.2951.729.4522.19ug/g12.7 ug/g14.3 ug/gDensityCreatinineTranfo 2013
194930MalesSubjects living in Central ItalyItalyITUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)74100.010.7720.163.099.9246.996.1816.95ug/g10.8 ug/g9.9 ug/gDensityCreatinineTranfo 2013
19509195131ChildrenMother-child pairs in the industrialized city of DuisburgGermanyDEThe Duisburg birth cohort studyUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)104100.028.625.232.4ug/g28.6 ug/gDensityCreatinineKasper-Sonnenberg 2012
19536195391MothersMother-child pairs in the industrialized city of DuisburgGermanyDEThe Duisburg birth cohort studyUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)103100.014.112.216.2ug/g14.1 ug/gDensityCreatinineKasper-Sonnenberg 2012
195510AllPregnant women in two French regionsFranceFRELFE (Étude Longitudinale Francaise depuis l’Enfance)deliveryUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)279184.1346.12.344.4698.62266.9ug/g184.1 ug/g44.4 ug/gDensityCreatinineZeman 2013
195710AllMothers in southern SwedenSwedenSEUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)383825.018.05.124.033.086.0ug/g25.0 ug/g24.0 ug/gDensityCreatinineHogberg 2008
196150AllPregnant womenNorwayNOMoBa (Norwegian Mother and Child Cohort)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)11029.01ug/g29.0 ug/gDensityCreatinineYe 2009
196310AllPregnant womenNetherlandsNLGeneration R studyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)10033.44ug/g33.4 ug/gDensityCreatinineYe 2009
196450AllPregnant womenUnited StatesUSNHANESUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)11122.8ug/g22.8 ug/gDensityCreatinineYe 2009
196860UrbanUrban and rural premenstrual girlsEgyptEGUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)2879.920.52.631.0347.0ng/mL0.1 mg/L0.0 mg/LDensitySpecific gravityColacino 2011
197020RuralUrban and rural premenstrual girlsEgyptEGUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)2931.24.73.123.899.4ng/mL0.0 mg/L0.0 mg/LDensitySpecific gravityColacino 2011
19709197112AllMinority pregnant women in New York cityUnited StatesUSCCCEH (Columbia Center for Children's Environmental Health)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)246100.020.22.510.419.943.4149.617.223.6ng/mL0.0 mg/L0.0 mg/LCrudeAdibi 2008
197520MalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)2318.18.712.318.523.624.324.4ug/g18.1 ug/g18.5 ug/gDensityCreatinineFromme 2007
197620FemalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)2721.78.010.418.345.453.063.0ug/g21.7 ug/g18.3 ug/gDensityCreatinineFromme 2007
197780AllGirls from New York City, New York, Cincinnati, Ohio, and northern CaliforniaUnited StatesUSUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)90100.028.03.41.425.91699.0ug/L0.0 mg/L0.0 mg/LCrudeWolff 2007
198050AllStudents from 1988-2003GermanyDEESB (German Environmental Specimen Bank)Urine, 24-hLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)6344.121.068.0282.0ug/g21.0 ug/gDensityCreatinineWittassek 2007
198730FemalesSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)9920.410.70.46.010.519.8299.0ng/mL0.0 mg/L0.0 mg/L0.0 mg/LCrudeGuo 2011
198870MalesSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)8436.212.00.36.211.917.21120.0ng/mL0.0 mg/L0.0 mg/L0.0 mg/LCrudeGuo 2011
199010AllSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)18310.5ug/g10.5 ug/gDensityCreatinineGuo 2011
199150ChineseSubjects from seven asian countriesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)407.77.1ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199290IndianSubjects from seven asian countriesIndiaINUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)2217.016.1ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199430JapaneseSubjects from seven asian countriesJapanJPUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)355.15.3ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199570KuwaitiSubjects from seven asian countriesKuwaitKWUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)4615.918.1ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199710MalaysianSubjects from seven asian countriesMalaysiaMYUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)299.310.3ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199850VietnameseSubjects from seven asian countriesViet NamVNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)306.76.7ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199990KoreanSubjects from seven asian countriesKorea, Republic ofKRUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)605.77.0ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
200060AllInhabitants of Erlangen and surroundingsGermanyDEUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)8557.265.96.940.2143.0449.0ug/g57.2 ug/g40.2 ug/gDensityCreatinineKoch 2003
200140MothersPregnant women and their childrenTaiwanTWpregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)10036.37.4933.22114.030.1843.67ug/g36.3 ug/g33.2 ug/gDensityCreatinineLin 2011
200570Children aged 5-6 yearsPregnant women and their childrenTaiwanTWUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)5982.269.0565.6103.0mg/L82.2 mg/L69.1 mg/LDensityCreatinineLin 2011
200680Children aged 2-3 yearsPregnant women and their childrenTaiwanTWUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)30140.4150.8594.4208.9ug/g140.4 ug/g150.9 ug/gDensityCreatinineLin 2011
201440AllGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)323623.511.523.448.0180.321.125.9ug/L0.0 mg/L0.0 mg/LCrudeSaravanabhavan 2013
201520MalesGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)163025.712.525.150.5185.922.528.8ug/L0.0 mg/L0.0 mg/LCrudeSaravanabhavan 2013
201660AllGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)323626.113.722.842.3162.123.728.5ug/g26.1 ug/g22.8 ug/gDensityCreatinineSaravanabhavan 2013
201730MalesGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)163024.012.620.739.8145.121.726.3ug/g24.0 ug/g20.7 ug/gDensityCreatinineSaravanabhavan 2013
201800ChildrenGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)103731.316.731.661.0179.528.034.6ug/L0.0 mg/L0.0 mg/LCrudeSaravanabhavan 2013
201960AllInfants from the Munich areaGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)2597.016.311.150.8122.0ug/L0.0 mg/L0.0 mg/LCrudeFromme 2013
202150AllPregnant women in JerusalemIsraelILpregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)1924.95.324.3133.8ug/g24.9 ug/g24.3 ug/gDensityCreatinineBerman 2009
202260MothersPregnant women and their childrenSpainESINMA (Environment and Childhood)pregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)11817.321.6ng/mL0.0 mg/LCrudeCasas 2011
202420ChildrenPregnant women and their childrenSpainESINMA (Environment and Childhood)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)1957.456.6ng/mL0.1 mg/LCrudeCasas 2011
203190AllPregnant womenPeruPEbaseline; 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)7989.04.13.44.9ug/L0.0 mg/LCrudeIrvin 2010
203280AllPregnant womenPeruPEbaseline; 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)7890.08.87.610.1ug/g8.8 ug/gDensityCreatinineIrvin 2010
203390AllPregnant women from RotterdamNetherlandsNLGeneration R studypregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)100100.014.34.70.56.914.030.0494.0ug/L0.0 mg/L0.0 mg/LCrudeYe 2008
203550AllPregnant women from RotterdamNetherlandsNLGeneration R studypregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)10022.23.43.713.220.332.3371.0ug/g22.2 ug/g20.3 ug/gDensityCreatinineYe 2008
203950AllCouples seeking infertility evaluation and treatment at the Massachusetts General Hospital Fertility CenterUnited StatesUSbaseline; 35 days; 70 daysUrine, spotLC-ID-MS/MSMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)2692.50.92.56.432.5358.0ng/mL0.0 mg/L0.0 mg/LCrudeMeeker 2012
204020AllCouples seeking infertility evaluation and treatment at the Massachusetts General Hospital Fertility CenterUnited StatesUSbaseline; 35 days; 70 daysUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)26932.44.110.632.393.0274.0502.08780.0ng/mL0.0 mg/L0.0 mg/LCrudeMeeker 2012

Intake values

No data available

Correlation values

No data available

Reproducibility values

IDMst. IDSubject groupPopulationCountryCountry codeCohortTime definitionBiological specimenExperimental methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication
10518239AllHmong womenUnited StatesUSFox River Environment and Diet Study cohort in Green Bay, Wisconsinbaseline; 15 days; 29.5 daysUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)19.520.3ug/gCreatinine450.130.00.3Peck 2010
34018685AllMinority childrenUnited StatesUSbaseline; 2 weeks; 1 month; 2 months, 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)84.876.4ug/gCreatinine350.240.790.25Teitelbaum 2008
38718734AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)32.6ng/mL330.210.00.450.5320.143Frederiksen 2013
39318750AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)23.7ng/mL330.190.00.50.6650.157Frederiksen 2013
40318764AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)25.3ng/mL330.090.00.330.4090.041Frederiksen 2013
43418806AllPregnant women living in the Northern karst area of Puerto RicoPuerto RicoPRPROTECT (Puerto Rico Testsite for Exploring Contamination Threats)baseline; 4 weeks; 8 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)10.711.5ng/mL1390.250.150.38Cantonwine 2014
44618822AllPregnant women living in the Northern karst area of Puerto RicoPuerto RicoPRPROTECT (Puerto Rico Testsite for Exploring Contamination Threats)baseline; 4 weeks; 8 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)ng/mLSpecific gravity1380.240.140.37Cantonwine 2014
50918908AllSubjects in the metropolitan Atlanta area non-occupationally exposed to phthalatesUnited StatesUSbaseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)33.628.05ug/gCreatinine80.25Preau 2010
51118906AllSubjects in the metropolitan Atlanta area non-occupationally exposed to phthalatesUnited StatesUSbaseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)37.629.8ug/gCreatinine80.17Preau 2010
51318910AllSubjects in the metropolitan Atlanta area non-occupationally exposed to phthalatesUnited StatesUSbaseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)55.944.7ug/gCreatinine80.31Preau 2010
52419413AllWomenUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)121.3107.9pmol/mgCreatinine400.430.210.680.580.43Townsend 2013
79319725Variability subgroupMinority pregnant women in New York cityUnited StatesUSCCCEH (Columbia Center for Children's Environmental Health)baseline; 2 weeks; 4 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)ng/mL280.36Adibi 2008
80619740AllAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)ug/gCreatinine500.2Fromme 2007
85520395AllCouples seeking infertility evaluation and treatment at the Massachusetts General Hospital Fertility CenterUnited StatesUSbaseline; 35 days; 70 daysUrine, spotLC-ID-MS/MSMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)2.52.5ng/mL2690.080.040.16Meeker 2012
86220402AllCouples seeking infertility evaluation and treatment at the Massachusetts General Hospital Fertility CenterUnited StatesUSbaseline; 35 days; 70 daysUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)32.432.3ng/mL2690.130.080.21Meeker 2012