Mono(2-ethyl-5-carboxypentyl) phthalate (MECPP)

ID1403
NameMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Synonyms5-cx-MEPP
StructureThumb
DescriptionMetabolite of mono(2-ethylhexyl) phthalate (MEHP); secondary metabolite of di(2-ethylhexyl) phthalate (DEHP).
GroupPhthalates
Sub-groupPhthalate monoesters
Exposure sourcePollution
UsePlasticizers
CAS number40809-41-4
PubChem ID148386
ChEBI ID
FooDB ID
HMDB ID

Biomarker measurements

Biomarker concentration values

IDParent IDDepthSubject groupPopulationCountryCountry codeCohortTime definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianAdjustment typeAdjusted onRegressed onExpressed asPublication
18238205181AllHmong womenUnited StatesUSFox River Environment and Diet Study cohort in Green Bay, Wisconsinbaseline; 15 days; 29.5 daysUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)45100.029.52.26.317.532.652.7164.4243.4ug/g29.5 ug/g32.6 ug/gDensityCreatininePeck 2010
187360AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)33100.03.186.7913.318.828.160.8348.0ng/mL0.0 mg/LCrudeFrederiksen 2013
187520AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)33100.00.773.1310.916.222.658.4116.0ng/mL0.0 mg/LCrudeFrederiksen 2013
187660AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)33100.04.355.219.9514.722.740.9385.0ng/mL0.0 mg/LCrudeFrederiksen 2013
188080AllPregnant women living in the Northern karst area of Puerto RicoPuerto RicoPRPROTECT (Puerto Rico Testsite for Exploring Contamination Threats)baseline; 4 weeks; 8 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)139100.019.611.619.933.272.6749.018.021.3ng/mL0.0 mg/L0.0 mg/LCrudeCantonwine 2014
18921205062AllWomenUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)4046.315.842.5214.8ng/mg46.3 ug/g42.5 ug/gDensityCreatinineTownsend 2013
192630AllChildren with and without asthma and/or allergiesDenmarkDKIECH (Danish Indoor Environment and Children’s Health)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)441100.062.9268.037.12.210.923.134.556.5135.8ng/mL0.1 mg/L0.0 mg/L0.0 mg/LCrudeLanger 2013
192940AllChildrenGermanyDEGerES IV (German Environmental Survey IV)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)59962.561.4151.0209.04490.058.966.2ug/L0.1 mg/L0.1 mg/LCrudeBecker 2009
193830AllPrimary school starters at the City of FrankfurtGermanyDEUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)111100.064.850.39.246.9158.0394.054.075.6ug/g64.8 ug/g50.3 ug/g46.9 ug/gDensityCreatinineKoch 2011
19415189222AllWomenUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)40150.451.4137.9697.4pmol/mg0.2 umol/g0.1 umol/gDensityCreatinineTownsend 2013
19453194541ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)14522.03.16.911.016.024.051.0435.0ug/g22.0 ug/g16.0 ug/gDensityCreatinineFrederiksen 2013
19470194711MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)14515.02.34.06.28.711.024.0480.0ug/g15.0 ug/g8.7 ug/gDensityCreatinineFrederiksen 2013
19511195131ChildrenMother-child pairs in the industrialized city of DuisburgGermanyDEThe Duisburg birth cohort studyUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)104100.040.836.445.7ug/g40.8 ug/gDensityCreatinineKasper-Sonnenberg 2012
19538195391MothersMother-child pairs in the industrialized city of DuisburgGermanyDEThe Duisburg birth cohort studyUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)103100.017.715.520.3ug/g17.7 ug/gDensityCreatinineKasper-Sonnenberg 2012
195530AllPregnant women in two French regionsFranceFRELFE (Étude Longitudinale Francaise depuis l’Enfance)deliveryUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)279176.6259.14.758.1675.61199.8ug/g176.6 ug/g58.1 ug/gDensityCreatinineZeman 2013
196170AllPregnant womenNorwayNOMoBa (Norwegian Mother and Child Cohort)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)11042.62ug/g42.6 ug/gDensityCreatinineYe 2009
196330AllPregnant womenNetherlandsNLGeneration R studyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)10042.21ug/g42.2 ug/gDensityCreatinineYe 2009
196890UrbanUrban and rural premenstrual girlsEgyptEGUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)28154.537.514.874.7644.4ng/mL0.2 mg/L0.1 mg/LDensitySpecific gravityColacino 2011
197050RuralUrban and rural premenstrual girlsEgyptEGUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)2982.611.410.268.6249.5ng/mL0.1 mg/L0.1 mg/LDensitySpecific gravityColacino 2011
19710197121AllMinority pregnant women in New York cityUnited StatesUSCCCEH (Columbia Center for Children's Environmental Health)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)246100.038.36.220.537.181.2232.233.344.0ng/mL0.0 mg/L0.0 mg/LCrudeAdibi 2008
197530MalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)2322.612.815.021.132.334.335.1ug/g22.6 ug/g21.1 ug/gDensityCreatinineFromme 2007
197630FemalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)2729.46.815.525.342.969.080.1ug/g29.4 ug/g25.3 ug/gDensityCreatinineFromme 2007
197770AllGirls from New York City, New York, Cincinnati, Ohio, and northern CaliforniaUnited StatesUSUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)90100.050.33.15.953.22260.0ug/L0.1 mg/L0.1 mg/LCrudeWolff 2007
198070AllStudents from 1988-2003GermanyDEESB (German Environmental Specimen Bank)Urine, 24-hLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)6342.926.484.2340.0ug/g26.4 ug/gDensityCreatinineWittassek 2007
198710FemalesSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)9955.130.51.015.230.258.2864.0ng/mL0.1 mg/L0.0 mg/L0.0 mg/LCrudeGuo 2011
198850MalesSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)8461.628.92.114.127.446.2867.0ng/mL0.1 mg/L0.0 mg/L0.0 mg/LCrudeGuo 2011
198990AllSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)18326.0ug/g26.0 ug/gDensityCreatinineGuo 2011
199130ChineseSubjects from seven asian countriesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)4016.311.5ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199270IndianSubjects from seven asian countriesIndiaINUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)2223.023.4ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199410JapaneseSubjects from seven asian countriesJapanJPUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)359.79.8ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199550KuwaitiSubjects from seven asian countriesKuwaitKWUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)4638.837.5ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199690MalaysianSubjects from seven asian countriesMalaysiaMYUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)2913.912.1ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199830VietnameseSubjects from seven asian countriesViet NamVNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)3018.819.1ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199970KoreanSubjects from seven asian countriesKorea, Republic ofKRUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)6017.117.8ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
200160MothersPregnant women and their childrenTaiwanTWpregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)10052.435.6944.693545.043.6262.83ug/g52.4 ug/g44.7 ug/gDensityCreatinineLin 2011
200480Mothers providing milk samplesPregnant women and their childrenTaiwanTWBreast milkLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)290.280.230.35mg/L0.3 mg/LCrudeLin 2011
200590Children aged 5-6 yearsPregnant women and their childrenTaiwanTWUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)59137.9131.86110.7171.7ug/g137.9 ug/g131.9 ug/gDensityCreatinineLin 2011
200700Children aged 2-3 yearsPregnant women and their childrenTaiwanTWUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)30241.0206.62164.0353.0ug/g241.0 ug/g206.6 ug/gDensityCreatinineLin 2011
200810NewbornsPregnant women and their childrenTaiwanTWCord serumLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)300.281.280.230.35ug/L0.0 mg/L0.0 mg/LCrudeLin 2011
201970AllInfants from the Munich areaGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)25100.026.818.471.3221.0ug/L0.0 mg/L0.0 mg/LCrudeFromme 2013
202140AllPregnant women in JerusalemIsraelILpregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)1935.013.741.1193.4ug/g35.0 ug/g41.1 ug/gDensityCreatinineBerman 2009
202250MothersPregnant women and their childrenSpainESINMA (Environment and Childhood)pregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)11832.240.7ng/mL0.0 mg/LCrudeCasas 2011
202410ChildrenPregnant women and their childrenSpainESINMA (Environment and Childhood)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)19115.094.0ng/mL0.1 mg/LCrudeCasas 2011
203180AllPregnant womenPeruPEbaseline; 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)79100.010.59.112.2ug/L0.0 mg/LCrudeIrvin 2010
203270AllPregnant womenPeruPEbaseline; 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)78100.022.720.425.3ug/g22.7 ug/gDensityCreatinineIrvin 2010
203410AllPregnant women from RotterdamNetherlandsNLGeneration R studypregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)100100.019.42.81.29.618.431.5421.0ug/L0.0 mg/L0.0 mg/LCrudeYe 2008
203570AllPregnant women from RotterdamNetherlandsNLGeneration R studypregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)10030.12.38.118.925.841.4317.0ug/g30.1 ug/g25.8 ug/gDensityCreatinineYe 2008
203970AllCouples seeking infertility evaluation and treatment at the Massachusetts General Hospital Fertility CenterUnited StatesUSbaseline; 35 days; 70 daysUrine, spotLC-ID-MS/MSMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)26921.03.17.919.656.6149.0305.05580.0ng/mL0.0 mg/L0.0 mg/LCrudeMeeker 2012
204040AllCouples seeking infertility evaluation and treatment at the Massachusetts General Hospital Fertility CenterUnited StatesUSbaseline; 35 days; 70 daysUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)26950.26.917.647.5142.0366.0658.07170.0ng/mL0.1 mg/L0.0 mg/LCrudeMeeker 2012

Intake values

No data available

Correlation values

No data available

Reproducibility values

IDMst. IDSubject groupPopulationCountryCountry codeCohortTime definitionBiological specimenExperimental methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication
10418238AllHmong womenUnited StatesUSFox River Environment and Diet Study cohort in Green Bay, Wisconsinbaseline; 15 days; 29.5 daysUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)29.532.6ug/gCreatinine450.180.00.33Peck 2010
43618808AllPregnant women living in the Northern karst area of Puerto RicoPuerto RicoPRPROTECT (Puerto Rico Testsite for Exploring Contamination Threats)baseline; 4 weeks; 8 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)19.619.9ng/mL1390.20.110.35Cantonwine 2014
44818824AllPregnant women living in the Northern karst area of Puerto RicoPuerto RicoPRPROTECT (Puerto Rico Testsite for Exploring Contamination Threats)baseline; 4 weeks; 8 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)ng/mLSpecific gravity1380.190.10.33Cantonwine 2014
52619415AllWomenUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)150.4137.9pmol/mgCreatinine400.390.170.660.460.29Townsend 2013
79419726Variability subgroupMinority pregnant women in New York cityUnited StatesUSCCCEH (Columbia Center for Children's Environmental Health)baseline; 2 weeks; 4 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)ng/mL280.33Adibi 2008
80719741AllAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)ug/gCreatinine500.3Fromme 2007
85720397AllCouples seeking infertility evaluation and treatment at the Massachusetts General Hospital Fertility CenterUnited StatesUSbaseline; 35 days; 70 daysUrine, spotLC-ID-MS/MSMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)21.019.6ng/mL2690.150.10.23Meeker 2012
86420404AllCouples seeking infertility evaluation and treatment at the Massachusetts General Hospital Fertility CenterUnited StatesUSbaseline; 35 days; 70 daysUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)50.247.5ng/mL2690.150.10.23Meeker 2012