Mono(3-carboxypropyl) phthalate (MCPP)

ID1404
NameMono(3-carboxypropyl) phthalate (MCPP)
SynonymsMono-(3-carboxypropyl) phthalate
StructureThumb
DescriptionNon-specific metabolite of several phthalates. Metabolite of mono-n-butyl phthalate (MnBP); secondary metabolite of di-n-butyl phthalate (DnBP). Metabolite of mono-n-octyl phthalate (MnOP); secondary metabolite of di-n-octyl phthalate (DnOP).
GroupPhthalates
Sub-groupPhthalate monoesters
Exposure sourcePollution
UsePlasticizers
CAS number66851-46-5
PubChem ID53435015
ChEBI ID
FooDB ID
HMDB ID

Biomarker measurements

Biomarker concentration values

IDParent IDDepthSubject groupPopulationCountryCountry codeCohortTime definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianAdjustment typeAdjusted onRegressed onExpressed asPublication
182360AllHmong womenUnited StatesUSFox River Environment and Diet Study cohort in Green Bay, Wisconsinbaseline; 15 days; 29.5 daysUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)4593.01.62.60.01.31.83.14.919.7ug/g1.6 ug/g1.8 ug/gDensityCreatininePeck 2010
186920AllMinority childrenUnited StatesUSbaseline; 2 weeks; 1 month; 2 months, 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)356.30.16.153.694.2ug/g6.3 ug/g6.1 ug/gDensityCreatinineTeitelbaum 2008
188140AllPregnant women living in the Northern karst area of Puerto RicoPuerto RicoPRPROTECT (Puerto Rico Testsite for Exploring Contamination Threats)baseline; 4 weeks; 8 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)13998.92.31.12.24.120.7109.02.02.5ng/mL0.0 mg/L0.0 mg/LCrudeCantonwine 2014
194560ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)14516.01.62.85.87.813.050.0410.0ug/g16.0 ug/g7.8 ug/gDensityCreatinineFrederiksen 2013
194730MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)1455.21.52.43.46.013.089.0ug/g5.2 ug/g3.4 ug/gDensityCreatinineFrederiksen 2013
19502195051ChildrenMother-child pairs in the industrialized city of DuisburgGermanyDEThe Duisburg birth cohort studyUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)10497.02.52.22.9ug/g2.5 ug/gDensityCreatinineKasper-Sonnenberg 2012
19529195321MothersMother-child pairs in the industrialized city of DuisburgGermanyDEThe Duisburg birth cohort studyUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)10355.00.550.40.6ug/g0.6 ug/gDensityCreatinineKasper-Sonnenberg 2012
195630AllPregnant women in two French regionsFranceFRELFE (Étude Longitudinale Francaise depuis l’Enfance)deliveryUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)27910.625.02.76.415.8128.5ug/g10.6 ug/g6.4 ug/gDensityCreatinineZeman 2013
195700AllMothers in southern SwedenSwedenSEUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)38252.44.60.51.62.716.0ug/g2.4 ug/g1.6 ug/gDensityCreatinineHogberg 2008
196100AllPregnant womenNorwayNOMoBa (Norwegian Mother and Child Cohort)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)1101.16ug/g1.2 ug/gDensityCreatinineYe 2009
196260AllPregnant womenNetherlandsNLGeneration R studyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)1001.82ug/g1.8 ug/gDensityCreatinineYe 2009
196400AllPregnant womenUnited StatesUSNHANESUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)1113.52ug/g3.5 ug/gDensityCreatinineYe 2009
196850UrbanUrban and rural premenstrual girlsEgyptEGUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)285.31.70.22.245.7ng/mL0.0 mg/L0.0 mg/LDensitySpecific gravityColacino 2011
197010RuralUrban and rural premenstrual girlsEgyptEGUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)292.10.60.11.114.6ng/mL0.0 mg/L0.0 mg/LDensitySpecific gravityColacino 2011
197170AllMinority pregnant women in New York cityUnited StatesUSCCCEH (Columbia Center for Children's Environmental Health)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)24689.01.90.31.12.03.88.01.62.2ng/mL0.0 mg/L0.0 mg/LCrudeAdibi 2008
197850AllGirls from New York City, New York, Cincinnati, Ohio, and northern CaliforniaUnited StatesUSUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)90100.06.12.90.46.376.9ug/L0.0 mg/L0.0 mg/LCrudeWolff 2007
198680FemalesSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)992.21.40.71.32.245.6ng/mL0.0 mg/L0.0 mg/L0.0 mg/LCrudeGuo 2011
198820MalesSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)841.81.30.61.22.510.0ng/mL0.0 mg/L0.0 mg/L0.0 mg/LCrudeGuo 2011
198960AllSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)1831.1ug/g1.1 ug/gDensityCreatinineGuo 2011
199100ChineseSubjects from seven asian countriesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)401.50.9ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199240IndianSubjects from seven asian countriesIndiaINUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)220.50.2ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199380JapaneseSubjects from seven asian countriesJapanJPUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)350.90.5ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199520KuwaitiSubjects from seven asian countriesKuwaitKWUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)463.12.7ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199660MalaysianSubjects from seven asian countriesMalaysiaMYUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)291.00.2ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199800VietnameseSubjects from seven asian countriesViet NamVNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)301.20.5ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199940KoreanSubjects from seven asian countriesKorea, Republic ofKRUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)601.2ng/mL0.0 mg/LCrudeGuo 2011
201410AllGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)32361.40.81.73.69.81.31.6ug/L0.0 mg/L0.0 mg/LCrudeSaravanabhavan 2013
201490MalesGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)16301.60.92.03.910.01.41.8ug/L0.0 mg/L0.0 mg/LCrudeSaravanabhavan 2013
201630AllGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)32361.60.81.63.08.31.51.7ug/g1.6 ug/g1.6 ug/gDensityCreatinineSaravanabhavan 2013
201700MalesGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)16301.50.81.53.17.61.41.6ug/g1.5 ug/g1.5 ug/gDensityCreatinineSaravanabhavan 2013
201770ChildrenGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)10372.71.43.15.513.42.23.1ug/L0.0 mg/L0.0 mg/LCrudeSaravanabhavan 2013
202110AllPregnant women in JerusalemIsraelILpregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)191.70.61.76.2ug/g1.7 ug/g1.7 ug/gDensityCreatinineBerman 2009
202290MothersPregnant women and their childrenSpainESINMA (Environment and Childhood)pregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)1181.52.0ng/mL0.0 mg/LCrudeCasas 2011
202450ChildrenPregnant women and their childrenSpainESINMA (Environment and Childhood)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)196.14.4ng/mL0.0 mg/LCrudeCasas 2011
203170AllPregnant womenPeruPEbaseline; 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)7945.00.30.20.3ug/L0.0 mg/LCrudeIrvin 2010
203260AllPregnant womenPeruPEbaseline; 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)7846.00.60.50.6ug/g0.6 ug/gDensityCreatinineIrvin 2010
203340AllPregnant women from RotterdamNetherlandsNLGeneration R studypregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)10094.00.82.80.51.01.68.2ug/L0.0 mg/L0.0 mg/LCrudeYe 2008
203500AllPregnant women from RotterdamNetherlandsNLGeneration R studypregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)1001.32.30.91.42.58.9ug/g1.3 ug/g1.4 ug/gDensityCreatinineYe 2008
203990AllCouples seeking infertility evaluation and treatment at the Massachusetts General Hospital Fertility CenterUnited StatesUSbaseline; 35 days; 70 daysUrine, spotLC-ID-MS/MSMono(3-carboxypropyl) phthalate (MCPP)2691.10.10.51.32.76.215.3225.0ng/mL0.0 mg/L0.0 mg/LCrudeMeeker 2012
204060AllCouples seeking infertility evaluation and treatment at the Massachusetts General Hospital Fertility CenterUnited StatesUSbaseline; 35 days; 70 daysUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)2692.10.30.82.24.910.925.3607.0ng/mL0.0 mg/L0.0 mg/LCrudeMeeker 2012

Intake values

No data available

Correlation values

No data available

Reproducibility values

IDMst. IDSubject groupPopulationCountryCountry codeCohortTime definitionBiological specimenExperimental methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication
10218236AllHmong womenUnited StatesUSFox River Environment and Diet Study cohort in Green Bay, Wisconsinbaseline; 15 days; 29.5 daysUrine, first morning spotLC-ID-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)1.61.8ug/gCreatinine450.590.510.65Peck 2010
34718692AllMinority childrenUnited StatesUSbaseline; 2 weeks; 1 month; 2 months, 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)6.36.1ug/gCreatinine350.210.880.23Teitelbaum 2008
44218814AllPregnant women living in the Northern karst area of Puerto RicoPuerto RicoPRPROTECT (Puerto Rico Testsite for Exploring Contamination Threats)baseline; 4 weeks; 8 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)2.32.2ng/mL1390.230.130.37Cantonwine 2014
45418830AllPregnant women living in the Northern karst area of Puerto RicoPuerto RicoPRPROTECT (Puerto Rico Testsite for Exploring Contamination Threats)baseline; 4 weeks; 8 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)ng/mLSpecific gravity1380.20.110.35Cantonwine 2014
79919733Variability subgroupMinority pregnant women in New York cityUnited StatesUSCCCEH (Columbia Center for Children's Environmental Health)baseline; 2 weeks; 4 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)ng/mL280.44Adibi 2008
85920399AllCouples seeking infertility evaluation and treatment at the Massachusetts General Hospital Fertility CenterUnited StatesUSbaseline; 35 days; 70 daysUrine, spotLC-ID-MS/MSMono(3-carboxypropyl) phthalate (MCPP)1.11.3ng/mL2690.220.160.3Meeker 2012
86620406AllCouples seeking infertility evaluation and treatment at the Massachusetts General Hospital Fertility CenterUnited StatesUSbaseline; 35 days; 70 daysUrine, spotLC-ID-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)2.12.2ng/mL2690.240.180.32Meeker 2012