Bisphenol A (BPA)

ID1418
NameBisphenol A (BPA)
Synonyms
StructureThumb
DescriptionDiet is considered to be the primary source of exposure to BPA through leaching from food packaging, but non-food sources may also contribute through dermal exposure or through inhalation (Geens et al., 2012).
GroupPhenols
Sub-groupBisphenols
Exposure sourcePollution
UseFood packaging
CAS number80-05-7
PubChem ID6623
ChEBI ID33216
FooDB IDFDB008856
HMDB IDHMDB32133

Biomarker measurements

Biomarker concentration values

IDParent IDDepthSubject groupPopulationCountryCountry codeCohortTime definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianAdjustment typeAdjusted onRegressed onExpressed asPublication
183450AllPregnant womenUnited StatesUSSARAEH (Advanced Reproductive Age and Environmental Health)baselineUrine, spotLC-ID-MS/MS after enzymatic hydrolysisBisphenol A (BPA)7162.00.00.67.0ug/L0.0 mg/LCrudePhilippat 2013
183900AllPregnant womenPuerto RicoPRPROTECT (Puerto Rico Testsite for Exploring Contamination Threats)baseline; 4 weeks; 8 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisBisphenol A (BPA)10597.92.61.32.54.413.997.42.32.9ng/mL0.0 mg/L0.0 mg/LCrudeMeeker 2013
187030AllMinority childrenUnited StatesUSbaseline; 2 weeks; 1 month; 2 months, 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)353.40.23.523.636.3ug/g3.4 ug/g3.5 ug/gDensityCreatinineTeitelbaum 2008
187060AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)3372.00.930.00.00.01.483.469.3631.50.661.31ng/mL0.0 mg/L0.0 mg/LCrudeLassen 2013
187140AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)3387.01.670.00.01.062.163.9117.532.31.252.24ng/mL0.0 mg/L0.0 mg/LCrudeLassen 2013
187220AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)3382.01.190.00.00.351.753.96.414.20.811.75ng/mL0.0 mg/L0.0 mg/LCrudeLassen 2013
188360AllParticipants in a prospective birth cohort study in CincinattiUnited StatesUSHealth Outcomes and Measures of the Environment StudybaselineUrine, spotLC-ID-MS/MS after enzymatic hydrolysisBisphenol A (BPA)3862.0ng/mL0.0 mg/LCrudeBraun 2011
188370AllParticipants in a prospective birth cohort study in CincinattiUnited StatesUSHealth Outcomes and Measures of the Environment Study10 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisBisphenol A (BPA)3701.8ng/mL0.0 mg/LCrudeBraun 2011
188380AllParticipants in a prospective birth cohort study in CincinattiUnited StatesUSHealth Outcomes and Measures of the Environment Study23 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisBisphenol A (BPA)3441.3ng/mL0.0 mg/LCrudeBraun 2011
188400AllParticipants in a prospective birth cohort study in CincinattiUnited StatesUSHealth Outcomes and Measures of the Environment StudybaselineUrine, spotLC-ID-MS/MS after enzymatic hydrolysisBisphenol A (BPA)3861.7ug/g1.7 ug/gDensityCreatinineBraun 2011
188410AllParticipants in a prospective birth cohort study in CincinattiUnited StatesUSHealth Outcomes and Measures of the Environment Study10 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisBisphenol A (BPA)3702.0ug/g2.0 ug/gDensityCreatinineBraun 2011
188420AllParticipants in a prospective birth cohort study in CincinattiUnited StatesUSHealth Outcomes and Measures of the Environment Study23 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisBisphenol A (BPA)3442.0ug/g2.0 ug/gDensityCreatinineBraun 2011
188960AllWomen seeking evaluation and treatment for infertility at the Massachusetts General HospitalUnited StatesUSEARTH (Environment and Reproductive Health)baseline; 12 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)1371.11.52.1ug/L0.0 mg/LDensitySpecific gravityBraun 2012
189040AllWomen seeking evaluation and treatment for infertility at the Massachusetts General HospitalUnited StatesUSEARTH (Environment and Reproductive Health)baseline; 15 weeks; 28 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)1371.11.52.3ug/L0.0 mg/LDensitySpecific gravityBraun 2012
194230MalesEldersSwedenSEPIVUSSerum, fastingLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)5024962.083.66.5727.3ng/mL0.0 mg/LCrudeOlsen 2012
194340FemalesEldersSwedenSEPIVUSSerum, fastingLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)5014951.973.896.5124.0ng/mL0.0 mg/LCrudeOlsen 2012
196510AllPregnant womenNorwayNOMoBa (Norwegian Mother and Child Cohort)Urine, spotGC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)1105.88ug/g5.9 ug/gDensityCreatinineYe 2009
196520AllPregnant womenNetherlandsNLGeneration R studyUrine, spotGC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)1002.91ug/g2.9 ug/gDensityCreatinineYe 2009
196530AllPregnant womenUnited StatesUSNHANESUrine, spotGC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)872.75ug/g2.8 ug/gDensityCreatinineYe 2009
197870AllGirls from New York City, New York, Cincinnati, Ohio, and northern CaliforniaUnited StatesUSUrine, spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)9094.42.03.21.854.3ug/L0.0 mg/L0.0 mg/LCrudeWolff 2007
201810AllGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotGC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)54761.161.081.24ug/L0.0 mg/LCrudeBushnik 2010
201820MalesGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotGC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)26591.291.21.38ug/L0.0 mg/LCrudeBushnik 2010
201830FemalesGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotGC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)28171.040.941.16ug/L0.0 mg/LCrudeBushnik 2010
201840AllGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotGC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)54761.41.321.49ug/g1.4 ug/gDensityCreatinineBushnik 2010
201850MalesGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotGC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)26591.281.181.38ug/g1.3 ug/gDensityCreatinineBushnik 2010
201860FemalesGeneral populationCanadaCACHMS (Canadian Health Measures Survey)Urine, spotGC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)28171.541.441.64ug/g1.5 ug/gDensityCreatinineBushnik 2010
202340MothersPregnant women and their childrenSpainESINMA (Environment and Childhood)pregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)1202.22.8ng/mL0.0 mg/LCrudeCasas 2011
202500ChildrenPregnant women and their childrenSpainESINMA (Environment and Childhood)Urine, spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)304.25.5ng/mL0.0 mg/LCrudeCasas 2011
203450AllPregnant women from RotterdamNetherlandsNLGeneration R studypregnancyUrine, spotGC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)10082.01.13.80.51.22.546.0ug/L0.0 mg/L0.0 mg/LCrudeYe 2008
203610AllPregnant women from RotterdamNetherlandsNLGeneration R studypregnancyUrine, spotGC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)1001.72.80.10.30.81.63.98.322.7ug/g1.7 ug/g1.6 ug/gDensityCreatinineYe 2008
204240AllPregnant Mexican-Americans or Mexican immigrants living in the Salinas ValleyUnited StatesUSCHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas)baselineUrine, spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)40779.10.92.80.51.01.763.2ug/L0.0 mg/L0.0 mg/LCrudeQuiros-Alcala 2013
204250AllPregnant Mexican-Americans or Mexican immigrants living in the Salinas ValleyUnited StatesUSCHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas)baselineUrine, spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)40779.11.12.40.61.11.827.0ug/g1.1 ug/g1.1 ug/gDensityCreatinineQuiros-Alcala 2013
204260AllPregnant Mexican-Americans or Mexican immigrants living in the Salinas ValleyUnited StatesUSCHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas)baselineUrine, spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)40779.11.22.40.71.11.950.6ug/L0.0 mg/L0.0 mg/LDensitySpecific gravityQuiros-Alcala 2013
204270AllPregnant Mexican-Americans or Mexican immigrants living in the Salinas ValleyUnited StatesUSCHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas)12 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)40782.11.02.60.51.01.832.8ug/L0.0 mg/L0.0 mg/LCrudeQuiros-Alcala 2013
204280AllPregnant Mexican-Americans or Mexican immigrants living in the Salinas ValleyUnited StatesUSCHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas)12 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)40782.11.22.20.71.11.847.6ug/g1.2 ug/g1.1 ug/gDensityCreatinineQuiros-Alcala 2013
204290AllPregnant Mexican-Americans or Mexican immigrants living in the Salinas ValleyUnited StatesUSCHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas)12 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)40782.11.22.20.71.21.931.5ug/L0.0 mg/L0.0 mg/LDensitySpecific gravityQuiros-Alcala 2013

Intake values

No data available

Correlation values

No data available

Reproducibility values

IDMst. IDSubject groupPopulationCountryCountry codeCohortTime definitionBiological specimenExperimental methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication
14118354AllPregnant womenUnited StatesUSSARAEH (Advanced Reproductive Age and Environmental Health)baseline; 5 weeks; 15 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisBisphenol A (BPA)ug/L710.23Philippat 2013
15018365AllPregnant womenUnited StatesUSSARAEH (Advanced Reproductive Age and Environmental Health)baseline; 5 weeks; 15 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisBisphenol A (BPA)ug/LCreatinine600.14Philippat 2013
16018390AllPregnant womenPuerto RicoPRPROTECT (Puerto Rico Testsite for Exploring Contamination Threats)baseline; 4 weeks; 8 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisBisphenol A (BPA)2.62.5ng/mL1050.270.150.42Meeker 2013
35818703AllMinority childrenUnited StatesUSbaseline; 2 weeks; 1 month; 2 months, 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)3.43.5ug/gCreatinine350.350.650.35Teitelbaum 2008
37118706AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)0.931.48ng/mL320.260.050.52.050.74Lassen 2013
37718722AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)1.191.75ng/mL310.420.090.671.451.04Lassen 2013
38018714AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)1.672.16ng/mL320.10.00.351.880.22Lassen 2013
46718835AllParticipants in a prospective birth cohort study in CincinattiUnited StatesUSHealth Outcomes and Measures of the Environment Studybaseline; 10 weeks; 23 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisBisphenol A (BPA)ng/mL3320.250.150.05Braun 2011
46818839AllParticipants in a prospective birth cohort study in CincinattiUnited StatesUSHealth Outcomes and Measures of the Environment Studybaseline; 10 weeks; 23 weeksUrine, spotLC-ID-MS/MS after enzymatic hydrolysisBisphenol A (BPA)ug/gCreatinine3320.10.110.01Braun 2011
50018896AllWomen seeking evaluation and treatment for infertility at the Massachusetts General HospitalUnited StatesUSEARTH (Environment and Reproductive Health)baseline; 12 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)1.5ug/LSpecific gravity1370.23Braun 2012
50818904AllWomen seeking evaluation and treatment for infertility at the Massachusetts General HospitalUnited StatesUSEARTH (Environment and Reproductive Health)baseline; 15 weeks; 28 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)1.5ug/LSpecific gravity1370.12Braun 2012
87520421AllPregnant Mexican-Americans or Mexican immigrants living in the Salinas ValleyUnited StatesUSCHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas)baseline; 12 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)ug/L3750.22Quiros-Alcala 2013
87620422AllPregnant Mexican-Americans or Mexican immigrants living in the Salinas ValleyUnited StatesUSCHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas)baseline; 12 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)ug/gCreatinine3750.14Quiros-Alcala 2013
87720423AllPregnant Mexican-Americans or Mexican immigrants living in the Salinas ValleyUnited StatesUSCHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas)baseline; 12 weeksUrine, spotLC-MS/MS after enzymatic hydrolysisBisphenol A (BPA)ug/LSpecific gravity3750.16Quiros-Alcala 2013