Mono-hydroxy-isononyl phthalate (OH-MiNP)

ID1451
NameMono-hydroxy-isononyl phthalate (OH-MiNP)
SynonymsMono(hydroxy-isononyl) phthalate; Mono(hydroxy-isononyl) phthalates; MHINP; MHNP; 7-OH-MiNP; 7-Hydroxy-(mono-methyl-octyl) phthalate; Mono(4-methyl-7-hydroxyoctyl) phthalate; Mono(4-methyl-7-hydroxy-octyl) phthalate; 7-OH-MMeOP; 7OH-MMeOP
StructureThumb
DescriptionMetabolite of mono-isononyl phthalate (MiNP); secondary metabolite of di-isononyl phthalate (DiNP). Structure for 4-methyl-7-OH- is represented.
GroupPhthalates
Sub-groupPhthalate monoesters
Exposure sourcePollution
UsePlasticizers
CAS number
PubChem ID
ChEBI ID
FooDB ID
HMDB ID

Biomarker measurements

Biomarker concentration values

IDParent IDDepthSubject groupPopulationCountryCountry codeCohortTime definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianAdjustment typeAdjusted onRegressed onExpressed asPublication
18739187431AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)3397.00.01.24.518.4212.938.3115.0ng/mL0.0 mg/LCrudeFrederiksen 2013
18755187591AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)3398.00.00.532.634.499.3521.861.0ng/mL0.0 mg/LCrudeFrederiksen 2013
18769187731AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)33100.00.771.493.195.689.3531.1204.0ng/mL0.0 mg/LCrudeFrederiksen 2013
192960AllChildrenGermanyDEGerES IV (German Environmental Survey IV)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)59911.211.037.650.6198.010.512.1ug/L0.0 mg/L0.0 mg/LCrudeBecker 2009
193590AllDemographically diverse group of U.S. adults of both sexesUnited StatesUSUrine, spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)129100.011.42.65.413.223.240.243.7ng/mL0.0 mg/L0.0 mg/LCrudeSilva 2006
193630AllDemographically diverse group of U.S. adults of both sexesUnited StatesUSUrine, spotLC-MS/MSMono-hydroxy-isononyl phthalate (OH-MiNP)82100.05.41.82.95.89.115.520.1ng/mL0.0 mg/L0.0 mg/LCrudeSilva 2006
193860AllPrimary school starters at the City of FrankfurtGermanyDEUrine, spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)11196.015.09.010.841.9115.012.117.9ug/g15.0 ug/g9.0 ug/g10.8 ug/gDensityCreatinineKoch 2011
19458194611ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)14514.00.881.63.05.010.028.0688.0ug/g14.0 ug/g5.0 ug/gDensityCreatinineFrederiksen 2013
19475194781MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)1455.10.581.42.65.417.053.0ug/g5.1 ug/g2.6 ug/gDensityCreatinineFrederiksen 2013
19514195171ChildrenMother-child pairs in the industrialized city of DuisburgGermanyDEThe Duisburg birth cohort studyUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)104100.015.113.516.8ug/g15.1 ug/gDensityCreatinineKasper-Sonnenberg 2012
19540195431MothersMother-child pairs in the industrialized city of DuisburgGermanyDEThe Duisburg birth cohort studyUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)103100.09.68.311.2ug/g9.6 ug/gDensityCreatinineKasper-Sonnenberg 2012
195590AllPregnant women in two French regionsFranceFRELFE (Étude Longitudinale Francaise depuis l’Enfance)deliveryUrine, spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)27910.020.10.73.840.2139.9ug/g10.0 ug/g3.8 ug/gDensityCreatinineZeman 2013
196200AllPregnant womenNorwayNOMoBa (Norwegian Mother and Child Cohort)Urine, spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)1107.48ug/g7.5 ug/gDensityCreatinineYe 2009
196360AllPregnant womenNorwayNOMoBa (Norwegian Mother and Child Cohort)Urine, spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)1109.94ug/g9.9 ug/gDensityCreatinineYe 2009
197550MalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)236.72.02.94.89.59.537.4ug/g6.7 ug/g4.8 ug/gDensityCreatinineFromme 2007
197660FemalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)276.41.22.85.411.513.221.0ug/g6.4 ug/g5.4 ug/gDensityCreatinineFromme 2007
198040AllStudents from 1988-2003GermanyDEESB (German Environmental Specimen Bank)Urine, 24-hLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)6341.911.1131.0ug/g1.9 ug/gDensityCreatinineWittassek 2007
200210MothersPregnant women and their childrenTaiwanTWpregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)1000.910.080.42267.50.061.38ug/g0.9 ug/g0.4 ug/gDensityCreatinineLin 2011
200640Children aged 5-6 yearsPregnant women and their childrenTaiwanTWUrine, spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)5921.817.7216.129.6ug/g21.8 ug/g17.7 ug/gDensityCreatinineLin 2011
200750Children aged 2-3 yearsPregnant women and their childrenTaiwanTWUrine, spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)306.7820.023.6612.58ug/g6.8 ug/g20.0 ug/gDensityCreatinineLin 2011
202010AllInfants from the Munich areaGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)253.09.57.415.516.3ug/L0.0 mg/L0.0 mg/LCrudeFromme 2013
203440AllPregnant women from RotterdamNetherlandsNLGeneration R studypregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)10098.03.03.61.42.56.5122.0ug/L0.0 mg/L0.0 mg/LCrudeYe 2008
203600AllPregnant women from RotterdamNetherlandsNLGeneration R studypregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)1004.62.92.34.27.095.7ug/g4.6 ug/g4.2 ug/gDensityCreatinineYe 2008

Intake values

No data available

Correlation values

No data available

Reproducibility values

IDMst. IDSubject groupPopulationCountryCountry codeCohortTime definitionBiological specimenExperimental methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication
81019744AllAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)ug/gCreatinine500.4Fromme 2007