Mono(2-carboxymethylhexyl) phthalate (MCMHP)

ID1490
NameMono(2-carboxymethylhexyl) phthalate (MCMHP)
SynonymsMono(2-carboxymethyl-hexyl) phthalate; 2-cx-MMHP; 2cx-MMHP
StructureThumb
DescriptionMetabolite of mono(2-ethylhexyl) phthalate (MEHP); secondary metabolite of di(2-ethylhexyl) phthalate (DEHP).
GroupPhthalates
Sub-groupPhthalate monoesters
Exposure sourcePollution
UsePlasticizers
CAS number82975-93-7
PubChem ID187353
ChEBI ID
FooDB ID
HMDB ID

Biomarker measurements

Biomarker concentration values

IDParent IDDepthSubject groupPopulationCountryCountry codeCohortTime definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianAdjustment typeAdjusted onRegressed onExpressed asPublication
192950AllChildrenGermanyDEGerES IV (German Environmental Survey IV)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)59920.820.451.776.71080.019.622.2ug/L0.0 mg/L0.0 mg/LCrudeBecker 2009
193840AllPrimary school starters at the City of FrankfurtGermanyDEUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)111100.027.219.04.018.669.3247.020.933.5ug/g27.2 ug/g19.0 ug/g18.6 ug/gDensityCreatinineKoch 2011
195540AllPregnant women in two French regionsFranceFRELFE (Étude Longitudinale Francaise depuis l’Enfance)deliveryUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)27935.785.62.015.3123.7726.0ug/g35.7 ug/g15.3 ug/gDensityCreatinineZeman 2013
196180AllPregnant womenNorwayNOMoBa (Norwegian Mother and Child Cohort)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)11018.29ug/g18.3 ug/gDensityCreatinineYe 2009
196340AllPregnant womenNorwayNOMoBa (Norwegian Mother and Child Cohort)Urine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)11012.77ug/g12.8 ug/gDensityCreatinineYe 2009
197540MalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)237.63.24.97.910.311.312.3ug/g7.6 ug/g7.9 ug/gDensityCreatinineFromme 2007
197640FemalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)279.94.54.88.816.422.131.6ug/g9.9 ug/g8.8 ug/gDensityCreatinineFromme 2007
198080AllStudents from 1988-2003GermanyDEESB (German Environmental Specimen Bank)Urine, 24-hLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)6342.08.730.1110.0ug/g8.7 ug/gDensityCreatinineWittassek 2007
198720FemalesSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)9940.720.81.712.218.733.9851.0ng/mL0.0 mg/L0.0 mg/L0.0 mg/LCrudeGuo 2011
198860MalesSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)8446.622.310.717.838.3646.0ng/mL0.0 mg/L0.0 mg/L0.0 mg/LCrudeGuo 2011
199000AllSubjects from three citiesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)18317.4ug/g17.4 ug/gDensityCreatinineGuo 2011
199140ChineseSubjects from seven asian countriesChinaCNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)4015.313.5ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199280IndianSubjects from seven asian countriesIndiaINUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)2228.426.2ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199420JapaneseSubjects from seven asian countriesJapanJPUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)356.46.1ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199560KuwaitiSubjects from seven asian countriesKuwaitKWUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)4651.249.2ng/mL0.1 mg/L0.0 mg/LCrudeGuo 2011
199700MalaysianSubjects from seven asian countriesMalaysiaMYUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)2912.413.1ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199840VietnameseSubjects from seven asian countriesViet NamVNUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)3017.818.3ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
199980KoreanSubjects from seven asian countriesKorea, Republic ofKRUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)6012.912.8ng/mL0.0 mg/L0.0 mg/LCrudeGuo 2011
200170MothersPregnant women and their childrenTaiwanTWpregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)10012.171.510.19756.09.9714.86ug/g12.2 ug/g10.2 ug/gDensityCreatinineLin 2011
200600Children aged 5-6 yearsPregnant women and their childrenTaiwanTWUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)5929.427.1623.337.0ug/g29.4 ug/g27.2 ug/gDensityCreatinineLin 2011
200710Children aged 2-3 yearsPregnant women and their childrenTaiwanTWUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)3054.554.0436.681.3ug/g54.5 ug/g54.0 ug/gDensityCreatinineLin 2011
200820NewbornsPregnant women and their childrenTaiwanTWCord serumLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)301.56ug/L0.0 mg/LCrudeLin 2011
201980AllInfants from the Munich areaGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)258.03.32.510.228.9ug/L0.0 mg/L0.0 mg/LCrudeFromme 2013
203420AllPregnant women from RotterdamNetherlandsNLGeneration R studypregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)100100.06.23.20.52.96.211.167.3ug/L0.0 mg/L0.0 mg/LCrudeYe 2008
203580AllPregnant women from RotterdamNetherlandsNLGeneration R studypregnancyUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)1009.72.61.65.59.116.173.6ug/g9.7 ug/g9.1 ug/gDensityCreatinineYe 2008

Intake values

No data available

Correlation values

No data available

Reproducibility values

IDMst. IDSubject groupPopulationCountryCountry codeCohortTime definitionBiological specimenExperimental methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication
80819742AllAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)ug/gCreatinine500.29Fromme 2007