O-Desmethylangolensin

ID17
NameO-Desmethylangolensin
SynonymsODMA
StructureThumb
DescriptionMetabolite of daidzein.
GroupPolyphenols
Sub-groupIsoflavones
Exposure sourceDiet
Use
CAS number21255-69-6
PubChem ID89472
ChEBI ID88902
FooDB IDFDB023387
HMDB IDHMDB04629

Biomarker measurements

Biomarker concentration values

IDParent IDDepthSubject groupPopulationCountryCountry codeCohortTime definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianAdjustment typeAdjusted onRegressed onExpressed asPublication
73771Quartile 1 (Isoflavone intake: 0.06 to 3.67 mg/day)Pubertal girlsKorea, Republic ofKRUrine, overnightLC-MS after enzymatic hydrolysisO-Desmethylangolensin121.0nmol/mg1.0 umol/gDensityCreatinineKim 2010
82851Quartile 4 (Isoflavone intake: 9.29 to 51.59 mg/day)Pubertal girlsKorea, Republic ofKRUrine, overnightLC-MS after enzymatic hydrolysisO-Desmethylangolensin121.9nmol/mg1.9 umol/gDensityCreatinineKim 2010
1110AllWomen in a high-risk program for breast or ovarian cancerUnited StatesUSFRAP (Family Risk Assessment Program)Urine, 24-hGC-MS after enzymatic hydrolysisO-Desmethylangolensin2788.9208.56.518.944.5ng/mg88.9 ug/g18.9 ug/gDensityCreatinineTseng 2008
1160AllWomen in a high-risk program for breast or ovarian cancerUnited StatesUSFRAP (Family Risk Assessment Program)Urine, overnightGC-MS after enzymatic hydrolysisO-Desmethylangolensin2793.4232.08.715.570.6ng/mg93.4 ug/g15.5 ug/gDensityCreatinineTseng 2008
7147172AllGeneral adult populationUnited StatesUSNHANES 1999-2002Urine, spotLC-MS/MS after enzymatic hydrolysisO-Desmethylangolensin29081.30.1ng/mL0.0 mg/LCrudeChun 2009
252525211AllMidle-aged and elderly womenChinaCNSWHS (Shanghai Women's Health Study)Urine, spotLC-MS/MS after enzymatic hydrolysisO-Desmethylangolensin21650.820.00.0170.050.321.524.479.8415.17135.970.730.93nmol/mg0.8 umol/g1.5 umol/gDensityCreatinineWu 2012
480048121AllCases and controls in a case-control study on breast cancer and dietUnited KingdomGBEPIC-Norfolk (European Prospective Investigation into Cancer and Nutrition)Urine, spotGC-ID-MS after enzymatic hydrolysisO-Desmethylangolensin3330.82.30.00.21.3226.3ug/mmol800.0 ug/mol200.0 ug/molDensityCreatinineGrace 2004
480748141AllCases and controls in a case-control study on breast cancer and dietUnited KingdomGBEPIC-Norfolk (European Prospective Investigation into Cancer and Nutrition)Serum, unspecifiedLC-ID-MS/MS after enzymatic hydrolysisO-Desmethylangolensin2840.11.50.00.00.231.9ng/mL0.0 mg/L0.0 mg/LCrudeGrace 2004
694369452All [by intake]Members of the University of Minnesota communityUnited StatesUSUrine, 24-hGC-MS after enzymatic hydrolysisO-Desmethylangolensin980.572.620.130.140.0319.49umol/day0.6 umol/day0.1 umol/dayCrudeLampe 1999
696369652High intake (Vegetables and fruits intake: ≥ 5 servings/day)Members of the University of Minnesota communityUnited StatesUSUrine, 24-hGC-MS after enzymatic hydrolysisO-Desmethylangolensin490.150.2umol/day0.1 umol/dayCrudeLampe 1999
697369752Low intake (Vegetables and fruits intake: ≤ 2 servings/day)Members of the University of Minnesota communityUnited StatesUSUrine, 24-hGC-MS after enzymatic hydrolysisO-Desmethylangolensin490.110.09umol/day0.1 umol/dayCrudeLampe 1999
71380O-DMA non-metabolizersMiddle-aged women from Tohoku regionJapanJPUrine, 24-hHPLC after enzymatic hydrolysisO-Desmethylangolensin170.0umol/day0.0 umol/dayCrudeArai 2000
71390O-DMA metabolizersMiddle-aged women from Tohoku regionJapanJPUrine, 24-hHPLC after enzymatic hydrolysisO-Desmethylangolensin893.36.40.20.71.63.456.3umol/day3.3 umol/day1.6 umol/dayCrudeArai 2000
71460Equol non-metabolizersMiddle-aged women from Tohoku regionJapanJPUrine, 24-hHPLC after enzymatic hydrolysisO-Desmethylangolensin532.1umol/day2.1 umol/dayCrudeArai 2000
71530Equol metabolizersMiddle-aged women from Tohoku regionJapanJPUrine, 24-hHPLC after enzymatic hydrolysisO-Desmethylangolensin531.1umol/day1.1 umol/dayCrudeArai 2000
781478101ChinesesWomen from two large mammography clinics in HonoluluUnited StatesUS1 dayUrine, overnightHPLC after enzymatic hydrolysisO-Desmethylangolensin1311.029.0nmol/h0.3 umol/dayCrudeMaskarinec 1998
782178171FilipinosWomen from two large mammography clinics in HonoluluUnited StatesUS1 dayUrine, overnightHPLC after enzymatic hydrolysisO-Desmethylangolensin714.034.0nmol/h0.3 umol/dayCrudeMaskarinec 1998
782878241Native HawaiiansWomen from two large mammography clinics in HonoluluUnited StatesUS1 dayUrine, overnightHPLC after enzymatic hydrolysisO-Desmethylangolensin1116.032.0nmol/h0.4 umol/dayCrudeMaskarinec 1998
783578311JapanesesWomen from two large mammography clinics in HonoluluUnited StatesUS1 dayUrine, overnightHPLC after enzymatic hydrolysisO-Desmethylangolensin2558.0146.0nmol/h1.4 umol/dayCrudeMaskarinec 1998
784278381CaucasiansWomen from two large mammography clinics in HonoluluUnited StatesUS1 dayUrine, overnightHPLC after enzymatic hydrolysisO-Desmethylangolensin4216.065.0nmol/h0.4 umol/dayCrudeMaskarinec 1998
784978451OthersWomen from two large mammography clinics in HonoluluUnited StatesUS1 dayUrine, overnightHPLC after enzymatic hydrolysisO-Desmethylangolensin40.0nmol/h0.0 umol/dayCrudeMaskarinec 1998
18698186991AllMinority childrenUnited StatesUSbaseline; 2 weeks; 1 month; 2 months, 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisO-Desmethylangolensin352.40.12.0114.4582.3ug/g2.4 ug/g2.0 ug/gDensityCreatinineTeitelbaum 2008
189300AllWomenUnited StatesUSNYUWHS (New York University Women's Health Study)baseline; 1 year; 2 yearsSerum, unspecifiedGC-MS after enzymatic hydrolysisO-Desmethylangolensin600.2nmol/L0.2 nmol/LCrudeZeleniuch-Jacquotte 1998
189380AllWomenUnited StatesUSNYUWHS (New York University Women's Health Study)baselineSerum, unspecifiedGC-MS after enzymatic hydrolysisO-Desmethylangolensin6036.70.00.00.51.91160.0nmol/L0.5 nmol/LCrudeZeleniuch-Jacquotte 1998
197760AllGirls from New York City, New York, Cincinnati, Ohio, and northern CaliforniaUnited StatesUSUrine, spotLC-MS/MS after enzymatic hydrolysisO-Desmethylangolensin9098.95.79.30.15.73210.0ug/L0.0 mg/L0.0 mg/LCrudeWolff 2007

Intake values

No data available

Correlation values

Reproducibility values

IDMst. IDSubject groupPopulationCountryCountry codeCohortTime definitionBiological specimenExperimental methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication
35318698AllMinority childrenUnited StatesUSbaseline; 2 weeks; 1 month; 2 months, 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisO-Desmethylangolensin2.42.0ug/gCreatinine350.42.421.59Teitelbaum 2008
53518930AllWomenUnited StatesUSNYUWHS (New York University Women's Health Study)baseline; 1 year; 2 yearsSerum, unspecifiedGC-MS after enzymatic hydrolysisO-Desmethylangolensin0.2nmol/L600.210.050.370.5370.145Zeleniuch-Jacquotte 1998