Cytidine (Compound)

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ID	2196
Name	Cytidine
Synonyms
Structure	MOL SDF PDB SMILES InChI Structure for EE002196 (Cytidine) 3D Structure for EE002196 (Cytidine) Mrv1652309032023512D 17 18 0 0 0 0 999 V2000 10000.1808 9998.4527 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 9998.3932 9998.4609 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 9997.925710000.3093 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9997.2110 9999.8986 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 10001.3995 9999.0747 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 10002.828910001.5463 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 10001.4009 9999.8967 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10002.115310000.3092 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 10002.115310001.1343 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10001.400910001.5468 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10000.686410001.1343 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10000.686410000.3092 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 9999.304010000.3929 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 9999.9714 9999.9079 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 9999.7165 9999.1233 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 9998.8915 9999.1233 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 9998.6366 9999.9079 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 3 4 1 0 0 0 0 9 10 1 0 0 0 0 10 11 2 0 0 0 0 7 8 1 0 0 0 0 8 9 2 0 0 0 0 11 12 1 0 0 0 0 12 7 1 0 0 0 0 7 5 2 0 0 0 0 9 6 1 0 0 0 0 14 15 1 0 0 0 0 15 16 1 0 0 0 0 16 17 1 0 0 0 0 13 14 1 0 0 0 0 13 17 1 0 0 0 0 15 1 1 6 0 0 0 14 12 1 1 0 0 0 17 3 1 1 0 0 0 16 2 1 6 0 0 0 M END > <DATABASE_ID> EE002196 > <DATABASE_NAME> ExposomeExplorer > <SMILES> NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O > <INCHI_IDENTIFIER> InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 > <INCHI_KEY> UHDGCWIWMRVCDJ-XVFCMESISA-N > <FORMULA> C9H13N3O5 > <MOLECULAR_WEIGHT> 243.2166 > <EXACT_MASS> 243.085520541 > <JCHEM_ACCEPTOR_COUNT> 7 > <JCHEM_ATOM_COUNT> 30 > <JCHEM_AVERAGE_POLARIZABILITY> 22.396851839019853 > <JCHEM_BIOAVAILABILITY> 1 > <JCHEM_DONOR_COUNT> 4 > <JCHEM_FORMAL_CHARGE> 0 > <JCHEM_GHOSE_FILTER> 0 > <JCHEM_IUPAC> 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one > <ALOGPS_LOGP> -2.18 > <JCHEM_LOGP> -2.7975172843333334 > <ALOGPS_LOGS> -0.74 > <JCHEM_MDDR_LIKE_RULE> 0 > <JCHEM_NUMBER_OF_RINGS> 2 > <JCHEM_PHYSIOLOGICAL_CHARGE> 0 > <JCHEM_PKA> 13.933688762534231 > <JCHEM_PKA_STRONGEST_ACIDIC> 12.553240841265485 > <JCHEM_PKA_STRONGEST_BASIC> -0.06234248538184939 > <JCHEM_POLAR_SURFACE_AREA> 128.60999999999999 > <JCHEM_REFRACTIVITY> 54.544799999999995 > <JCHEM_ROTATABLE_BOND_COUNT> 2 > <JCHEM_RULE_OF_FIVE> 1 > <ALOGPS_SOLUBILITY> 4.38e+01 g/l > <JCHEM_TRADITIONAL_IUPAC> cytidine > <JCHEM_VEBER_RULE> 0 $$$$
Description	A ribonucleoside, formed when cytosine is attached to a ribose ring.
Classification	Compounds > Chemical entities > Organic compounds > Nucleosides, nucleotides, and analogues > Pyrimidine nucleosides
CAS number	65-46-3
PubChem ID	6175
ChEBI ID	17562
FooDB ID	FDB021809
HMDB ID	HMDB0000089

Chemical data

MolDBi data

IUPAC Name	4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one
Traditional IUPAC Name	cytidine
Formula	C9H13N3O5
InChI	InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1
InChI Key	UHDGCWIWMRVCDJ-XVFCMESISA-N
Molecular weight	243.2166
Exact mass	243.085520541
SMILES	NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

ClassyFire Taxonomy

Description	belongs to the class of organic compounds known as pyrimidine nucleosides. Pyrimidine nucleosides are compounds comprising a pyrimidine base attached to a ribosyl or deoxyribosyl moiety.
Kingdom	Organic compounds
Super Class	Nucleosides, nucleotides, and analogues
Class	Pyrimidine nucleosides
Sub Class	Not Available
Direct Parent	Pyrimidine nucleosides
Alternative Parents	Glycosylamines Pentoses Pyrimidones Aminopyrimidines and derivatives Imidolactams Hydropyrimidines Tetrahydrofurans Heteroaromatic compounds Secondary alcohols Azacyclic compounds Oxacyclic compounds Hydrocarbon derivatives Organic oxides Organopnictogen compounds Primary alcohols Primary amines

Publications with Cytidine

ID	Title	First author	Authors	Year	Journal	Volume	Issue	Pages	PubMed ID	DOI	Study design	No. of Biomarkers	No. of Intake values	No. of Concentration values	No. of Reproducibility values	No. of Correlation values	No. of Metabolomic associations	No. of Microbiota associations	No. of Cancer associations

Biomarker data

Measurements of Cytidine in biospecimens

Concentration values

ID	Parent ID	Depth	Subject group	Population	Country	Cohort	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Measurement size	Detected (nb)	Detected (%)	Detected only?	Arithmethic mean	Arithmethic SD	Geometric mean	Geometric SD	Min	Min (detected)	Percentile_05	Percentile_10	Percentile_25	Median	Percentile_75	Percentile_90	Percentile_95	Max	Interquartile range	Mean 95% CI lower	Mean 95% CI upper	GMean 95% CI lower	GMean 95% CI upper	Unit	Converted arithmetic mean	Converted geometric mean	Converted median	Converted unit	Adjustment type	Adjusted on	Regressed on	Expressed as	Publication

Reproducibility values

ID	Excretion ID	Subject group	Population	Country	Cohort	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Arithmetic mean	Geometric mean	Median	Unit	Adjusted on	Reproducibility size	ICC	ICC 95% CI lower	ICC 95% CI upper	CV% WS	CV% BS	VAR WS	VAR BS	Publication

Associations of Cytidine with exposures

Correlation values

ID	Intake ID	Excretion ID	Subject group	Population	Country	Cohort	Intake Time definition	Intake Assessment method	Intake	Intake detail	Supplement intakes included?	Intake Arithmetic mean	Intake Geometric mean	Intake Median	Intake Unit	Intake Adjusted on	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Biomarker Arithmetic mean	Biomarker Geometric mean	Biomarker Median	Biomarker Unit	Biomarker Adjusted on	Correlation size	Correlation type	Correlation value	Correlation 95% CI lower	Correlation 95% CI upper	Correlation p-value	Significant?	Measurement adjustment	Deattenuated?	Covariates	Publication

Metabolomic associations

ID	Intake ID	Excretion ID	Subject group	Population	Country	Cohort	No. of subjects	Intake Assessment method	Intake	Intervention dose	Biospecimen	Analytical method	Biomarker	Structural identification	Feature selection	Area under curve	Sensitivity	Specificity	PLS-DA VIP	Beta coefficient	Beta coefficient p-value	ANOVA p-value	Publication

Microbiota associations

ID	Biomarker	Experimental evidence	Organism	Biospecimen	Antibiotic	Bacterial source	Substrate	Publication

Associations of Cytidine with cancer risk

Cancer associations

ID	Excretion ID	Subject group	Population	Country	Cohort	No. of subjects	No. of cases	No. of controls	Biospecimen	Analytical method	Biomarker	Biomarker detail	Cancer	Study design	Publication

Exposure data

Measurements of Cytidine exposures in populations

Intake values

ID	Parent ID	Depth	Subject group	Population	Country	Cohort	Intake Time definition	Intake assessment tool	Intake food coverage	Intake time coverage	Intake Assessment method	Intake	Intake detail	Food description	Supplement intakes included?	Measurement size	Detected (nb)	Detected (%)	Detected only?	Arithmethic mean	Arithmethic SD	Geometric mean	Geometric SD	Min	Min (detected)	Percentile_05	Percentile_10	Percentile_25	Median	Percentile_75	Percentile_90	Percentile_95	Max	Interquartile range	Mean 95% CI lower	Mean 95% CI upper	GMean 95% CI lower	GMean 95% CI upper	Unit	Converted arithmetic mean	Converted geometric mean	Converted median	Converted unit	Adjustment type	Adjusted on	Regressed on	Expressed as	Publication

Associations of Cytidine exposures with biomarkers

Correlation values

ID	Intake ID	Excretion ID	Subject group	Population	Country	Cohort	Intake Time definition	Intake Assessment method	Intake	Intake detail	Supplement intakes included?	Intake Arithmetic mean	Intake Geometric mean	Intake Median	Intake Unit	Intake Adjusted on	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Biomarker Arithmetic mean	Biomarker Geometric mean	Biomarker Median	Biomarker Unit	Biomarker Adjusted on	Correlation size	Correlation type	Correlation value	Correlation 95% CI lower	Correlation 95% CI upper	Correlation p-value	Significant?	Measurement adjustment	Deattenuated?	Covariates	Publication