Uracil (Compound)

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ID	2228
Name	Uracil
Synonyms	2,4-Dihydroxypyrimidine
Structure	MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure Structure for EE002228 (Uracil) 3D Structure for EE002228 (Uracil) 1174 -OEChem-03112021543D 12 12 0 0 0 0 0 0 0999 V2000 2.3264 0.9651 0.0001 O 0 0 0 0 0 0 0 0 0 0 0 0 -2.2972 1.0232 0.0005 O 0 0 0 0 0 0 0 0 0 0 0 0 0.0180 1.0199 -0.0002 N 0 0 0 0 0 0 0 0 0 0 0 0 1.1637 -1.0221 0.0001 N 0 0 0 0 0 0 0 0 0 0 0 0 1.2524 0.3629 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.2315 0.4141 -0.0004 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.0268 -1.6955 0.0002 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.2049 -1.0676 -0.0002 C 0 0 0 0 0 0 0 0 0 0 0 0 0.0382 2.0357 -0.0001 H 0 0 0 0 0 0 0 0 0 0 0 0 2.0187 -1.5702 0.0004 H 0 0 0 0 0 0 0 0 0 0 0 0 -2.1443 -1.6063 -0.0002 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0469 -2.7761 0.0004 H 0 0 0 0 0 0 0 0 0 0 0 0 1 5 2 0 0 0 0 2 6 2 0 0 0 0 3 5 1 0 0 0 0 3 6 1 0 0 0 0 3 9 1 0 0 0 0 4 5 1 0 0 0 0 4 7 1 0 0 0 0 4 10 1 0 0 0 0 6 8 1 0 0 0 0 7 8 2 0 0 0 0 7 12 1 0 0 0 0 8 11 1 0 0 0 0 M END > <PUBCHEM_COMPOUND_CID> 1174 > <PUBCHEM_CONFORMER_RMSD> 0.4 > <PUBCHEM_CONFORMER_DIVERSEORDER> 1 > <PUBCHEM_MMFF94_PARTIAL_CHARGES> 12 1 -0.57 10 0.37 11 0.15 12 0.15 2 -0.57 3 -0.49 4 -0.54 5 0.69 6 0.62 7 -0.04 8 -0.14 9 0.37 > <PUBCHEM_EFFECTIVE_ROTOR_COUNT> 0 > <PUBCHEM_PHARMACOPHORE_FEATURES> 5 1 1 acceptor 1 2 acceptor 1 3 donor 1 4 donor 6 3 4 5 6 7 8 rings > <PUBCHEM_HEAVY_ATOM_COUNT> 8 > <PUBCHEM_ATOM_DEF_STEREO_COUNT> 0 > <PUBCHEM_ATOM_UDEF_STEREO_COUNT> 0 > <PUBCHEM_BOND_DEF_STEREO_COUNT> 0 > <PUBCHEM_BOND_UDEF_STEREO_COUNT> 0 > <PUBCHEM_ISOTOPIC_ATOM_COUNT> 0 > <PUBCHEM_COMPONENT_COUNT> 1 > <PUBCHEM_CACTVS_TAUTO_COUNT> 6 > <PUBCHEM_CONFORMER_ID> 0000049600000001 > <PUBCHEM_MMFF94_ENERGY> 14.3175 > <PUBCHEM_FEATURE_SELFOVERLAP> 25.414 > <PUBCHEM_SHAPE_FINGERPRINT> 16714656 1 18122631818627685974 20096714 4 18338798918436485579 21040471 1 18410856568303635652 23552423 10 18188493587740016174 29004967 10 17903364710251125027 > <PUBCHEM_SHAPE_MULTIPOLES> 142.94 2.47 1.61 0.57 0.32 0.47 0 -1 0 -0.19 0 -0.02 0.03 0 > <PUBCHEM_SHAPE_SELFOVERLAP> 293.98 > <PUBCHEM_SHAPE_VOLUME> 81.1 > <PUBCHEM_COORDINATE_TYPE> 2 5 10 $$$$
Description	One of the four main bases found in DNA and RNA, which are adenine, cytosine, guanine, and thymine (uracil in RNA).
Classification	Compounds > Chemical entities > Organic compounds > Organoheterocyclic compounds > Diazines > Pyrimidines and pyrimidine derivatives > Pyrimidones
CAS number	66-22-8
PubChem ID	1174
ChEBI ID	17568
FooDB ID	FDB006426
HMDB ID	HMDB0000300

Chemical data

MolDBi data

IUPAC Name	1,2,3,4-tetrahydropyrimidine-2,4-dione
Traditional IUPAC Name	uracil
Formula	C4H4N2O2
InChI	InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)
InChI Key	ISAKRJDGNUQOIC-UHFFFAOYSA-N
Molecular weight	112.0868
Exact mass	112.027277382
SMILES	O=C1NC=CC(=O)N1

ClassyFire Taxonomy

Description	belongs to the class of organic compounds known as pyrimidones. Pyrimidones are compounds that contain a pyrimidine ring, which bears a ketone. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions.
Kingdom	Organic compounds
Super Class	Organoheterocyclic compounds
Class	Diazines
Sub Class	Pyrimidines and pyrimidine derivatives
Direct Parent	Pyrimidones
Alternative Parents	Hydropyrimidines Vinylogous amides Heteroaromatic compounds Ureas Lactams Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives

Publications with Uracil

ID	Title	First author	Authors	Year	Journal	Volume	Issue	Pages	PubMed ID	DOI	Study design	No. of Biomarkers	No. of Intake values	No. of Concentration values	No. of Reproducibility values	No. of Correlation values	No. of Metabolomic associations	No. of Microbiota associations	No. of Cancer associations

Biomarker data

Measurements of Uracil in biospecimens

Concentration values

ID	Parent ID	Depth	Subject group	Population	Country	Cohort	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Measurement size	Detected (nb)	Detected (%)	Detected only?	Arithmethic mean	Arithmethic SD	Geometric mean	Geometric SD	Min	Min (detected)	Percentile_05	Percentile_10	Percentile_25	Median	Percentile_75	Percentile_90	Percentile_95	Max	Interquartile range	Mean 95% CI lower	Mean 95% CI upper	GMean 95% CI lower	GMean 95% CI upper	Unit	Converted arithmetic mean	Converted geometric mean	Converted median	Converted unit	Adjustment type	Adjusted on	Regressed on	Expressed as	Publication

Reproducibility values

ID	Excretion ID	Subject group	Population	Country	Cohort	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Arithmetic mean	Geometric mean	Median	Unit	Adjusted on	Reproducibility size	ICC	ICC 95% CI lower	ICC 95% CI upper	CV% WS	CV% BS	VAR WS	VAR BS	Publication

Associations of Uracil with exposures

Correlation values

ID	Intake ID	Excretion ID	Subject group	Population	Country	Cohort	Intake Time definition	Intake Assessment method	Intake	Intake detail	Supplement intakes included?	Intake Arithmetic mean	Intake Geometric mean	Intake Median	Intake Unit	Intake Adjusted on	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Biomarker Arithmetic mean	Biomarker Geometric mean	Biomarker Median	Biomarker Unit	Biomarker Adjusted on	Correlation size	Correlation type	Correlation value	Correlation 95% CI lower	Correlation 95% CI upper	Correlation p-value	Significant?	Measurement adjustment	Deattenuated?	Covariates	Publication

Metabolomic associations

ID	Intake ID	Excretion ID	Subject group	Population	Country	Cohort	No. of subjects	Intake Assessment method	Intake	Intervention dose	Biospecimen	Analytical method	Biomarker	Structural identification	Feature selection	Area under curve	Sensitivity	Specificity	PLS-DA VIP	Beta coefficient	Beta coefficient p-value	ANOVA p-value	Publication

Microbiota associations

ID	Biomarker	Experimental evidence	Organism	Biospecimen	Antibiotic	Bacterial source	Substrate	Publication

Associations of Uracil with cancer risk

Cancer associations

ID	Excretion ID	Subject group	Population	Country	Cohort	No. of subjects	No. of cases	No. of controls	Biospecimen	Analytical method	Biomarker	Biomarker detail	Cancer	Study design	Publication

Exposure data

Measurements of Uracil exposures in populations

Intake values

ID	Parent ID	Depth	Subject group	Population	Country	Cohort	Intake Time definition	Intake assessment tool	Intake food coverage	Intake time coverage	Intake Assessment method	Intake	Intake detail	Food description	Supplement intakes included?	Measurement size	Detected (nb)	Detected (%)	Detected only?	Arithmethic mean	Arithmethic SD	Geometric mean	Geometric SD	Min	Min (detected)	Percentile_05	Percentile_10	Percentile_25	Median	Percentile_75	Percentile_90	Percentile_95	Max	Interquartile range	Mean 95% CI lower	Mean 95% CI upper	GMean 95% CI lower	GMean 95% CI upper	Unit	Converted arithmetic mean	Converted geometric mean	Converted median	Converted unit	Adjustment type	Adjusted on	Regressed on	Expressed as	Publication

Associations of Uracil exposures with biomarkers

Correlation values

ID	Intake ID	Excretion ID	Subject group	Population	Country	Cohort	Intake Time definition	Intake Assessment method	Intake	Intake detail	Supplement intakes included?	Intake Arithmetic mean	Intake Geometric mean	Intake Median	Intake Unit	Intake Adjusted on	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Biomarker Arithmetic mean	Biomarker Geometric mean	Biomarker Median	Biomarker Unit	Biomarker Adjusted on	Correlation size	Correlation type	Correlation value	Correlation 95% CI lower	Correlation 95% CI upper	Correlation p-value	Significant?	Measurement adjustment	Deattenuated?	Covariates	Publication