Ascorbic acid

ID236
NameAscorbic acid
Synonyms[Vitamin C] / Ascorbic acid, reduced; Vitamin C; L-Ascorbic acid
StructureThumb
DescriptionReduced form of ascorbic acid.
GroupCarboxylic acids
Sub-groupKetoaldonic acids
Exposure sourceDiet
UseVitamins
CAS number50-81-7
PubChem ID54670067
ChEBI ID29073
FooDB IDFDB001224
HMDB IDHMDB00044

Biomarker measurements

Biomarker concentration values

IDParent IDDepthSubject groupPopulationCountryCountry codeCohortTime definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianAdjustment typeAdjusted onRegressed onExpressed asPublication
12340MalesParticipants in a dietary validation studyJapanJPJPHC StudyPlasma, fastingSpectrophotometryAscorbic acid901.170.27mg/dL11.7 mg/LCrudeKobayashi 2011
12410FemalesParticipants in a dietary validation studyJapanJPJPHC StudyPlasma, fastingSpectrophotometryAscorbic acid1011.310.32mg/dL13.1 mg/LCrudeKobayashi 2011
21160WhitesWhites and African Americans in North CarolinaUnited StatesUSDISH (DIet, Supplements, and Health Study)Plasma, semi-fastingHPLCAscorbic acid817.019.069.87umol/L9060.0 nmol/LCrudeSatia 2009
21400African AmericansWhites and African Americans in North CarolinaUnited StatesUSDISH (DIet, Supplements, and Health Study)Plasma, semi-fastingHPLCAscorbic acid836.598.199.69umol/L8190.0 nmol/LCrudeSatia 2009
60690Non-Hispanic BlacksBlack and white Seventh-day Adventists participant in a dietary validation studyUnited StatesUSAHS (Adventist Health Study)Leukocytes, fastingHPLCAscorbic acid9725.19.9ug/10^8 cells25.1 ug/10^8 cellsCrudeKnutsen 2001
60730Non-Hispanic Blacks - MalesBlack and white Seventh-day Adventists participant in a dietary validation studyUnited StatesUSAHS (Adventist Health Study)Leukocytes, fastingHPLCAscorbic acid3623.49.3ug/10^8 cells23.4 ug/10^8 cellsCrudeKnutsen 2001
60770Non-Hispanic Blacks - FemalesBlack and white Seventh-day Adventists participant in a dietary validation studyUnited StatesUSAHS (Adventist Health Study)Leukocytes, fastingHPLCAscorbic acid6126.010.2ug/10^8 cells26.0 ug/10^8 cellsCrudeKnutsen 2001
60810Non-Hispanic WhitesBlack and white Seventh-day Adventists participant in a dietary validation studyUnited StatesUSAHS (Adventist Health Study)Leukocytes, fastingHPLCAscorbic acid9628.812.2ug/10^8 cells28.8 ug/10^8 cellsCrudeKnutsen 2001
60850Non-Hispanic Whites - MalesBlack and white Seventh-day Adventists participant in a dietary validation studyUnited StatesUSAHS (Adventist Health Study)Leukocytes, fastingHPLCAscorbic acid4026.710.7ug/10^8 cells26.7 ug/10^8 cellsCrudeKnutsen 2001
60890Non-Hispanic Whites - FemalesBlack and white Seventh-day Adventists participant in a dietary validation studyUnited StatesUSAHS (Adventist Health Study)Leukocytes, fastingHPLCAscorbic acid5630.313.0ug/10^8 cells30.3 ug/10^8 cellsCrudeKnutsen 2001
74000MalesParticipants in an investigation of antioxidant intake and adult onset asthma in ScotlandUnited KingdomGBPlasma, unspecifiedColorimetryAscorbic acid11840.520.80.038.5107.0umol/L40500.0 nmol/L38500.0 nmol/LCrudeBodner 1998
74040FemalesParticipants in an investigation of antioxidant intake and adult onset asthma in ScotlandUnited KingdomGBPlasma, unspecifiedColorimetryAscorbic acid15552.825.64.053.0131.0umol/L52800.0 nmol/L53000.0 nmol/LCrudeBodner 1998
184630AllSmokers and nonsmokers exposed to second-hand smokeUnited StatesUSStudy on the effect of antioxidant supplements on oxidative damage in active and passive smokersbaseline; 2 weeksPlasma, fastingSpectrophotometryAscorbic acid2060.860.420.87mg/dL8.6 mg/L8.7 mg/LCrudeBlock 2006

Intake values

No data available

Correlation values

Reproducibility values

IDMst. IDSubject groupPopulationCountryCountry codeCohortTime definitionBiological specimenExperimental methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication
421756All [by diagnosis]Elderly subjects with and without mild cognitive impairmentUnited StatesUSbaseline; 1 monthPlasma, fastingHPLCAscorbic acidmissing unit380.49Bowman 2011
741734No cognitive impairmentElderly subjects with and without mild cognitive impairmentUnited StatesUSbaseline; 1 monthPlasma, fastingHPLCAscorbic acidmissing unit190.1Bowman 2011
961712Mild cognitive impairmentElderly subjects with and without mild cognitive impairmentUnited StatesUSbaseline; 1 monthPlasma, fastingHPLCAscorbic acidmissing unit190.69Bowman 2011
16818463AllSmokers and nonsmokers exposed to second-hand smokeUnited StatesUSStudy on the effect of antioxidant supplements on oxidative damage in active and passive smokersbaseline; 2 weeksPlasma, fastingSpectrophotometryAscorbic acid0.860.87mg/dL2060.840.0090.044Block 2006
66619123MalesCollege students consuming a semi-purified diet with water-soluble vitaminsJapanJPbaseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 daysUrine, 24-hHPLCAscorbic acidmmol/L1027.044.7Shibata 2009
67519132MalesCollege students consuming a semi-purified diet with water-soluble vitaminsJapanJPbaseline; 2 day; 4 days; 7 daysWhole blood, fastingHPLCAscorbic acidmmol/L1018.217.3Shibata 2009
68419141FemalesCollege students consuming a semi-purified diet with water-soluble vitaminsJapanJPbaseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 daysUrine, 24-hHPLCAscorbic acidmmol/L1042.644.9Shibata 2009
69319150FemalesCollege students consuming a semi-purified diet with water-soluble vitaminsJapanJPbaseline; 2 day; 7 daysWhole blood, fastingHPLCAscorbic acidmmol/L1065.518.6Shibata 2009