Urolithin A (Compound)

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ID	2465
Name	Urolithin A
Synonyms	3,8-Dihydroxyurolithin; 3,8-Dihydroxy-6H-dibenzo(b,d)pyran-6-one
Structure	MOL SDF PDB SMILES InChI Structure for EE002465 (Urolithin A) 3D Structure for EE002465 (Urolithin A) Mrv1652303102016532D 17 19 0 0 0 0 999 V2000 -1.0326 -0.1759 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.2076 -0.1759 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.2049 0.5386 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0299 0.5386 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4423 -0.1759 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0299 -0.8904 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.2049 -0.8904 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2674 -0.1759 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6799 0.5386 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5049 0.5386 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9174 -0.1759 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.7424 -0.1759 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.5049 -0.8904 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6799 -0.8904 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2674 1.2531 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.6799 1.9675 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1.4423 1.2531 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 2 3 2 0 0 0 0 3 4 1 0 0 0 0 4 5 2 0 0 0 0 5 6 1 0 0 0 0 6 7 2 0 0 0 0 2 7 1 0 0 0 0 5 8 1 0 0 0 0 8 9 2 0 0 0 0 9 10 1 0 0 0 0 10 11 2 0 0 0 0 11 12 1 0 0 0 0 11 13 1 0 0 0 0 13 14 2 0 0 0 0 8 14 1 0 0 0 0 9 15 1 0 0 0 0 15 16 2 0 0 0 0 15 17 1 0 0 0 0 4 17 1 0 0 0 0 M END > <DATABASE_ID> EE002465 > <DATABASE_NAME> ExposomeExplorer > <SMILES> OC1=CC2=C(C=C1)C1=C(C=C(O)C=C1)C(=O)O2 > <INCHI_IDENTIFIER> InChI=1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H > <INCHI_KEY> RIUPLDUFZCXCHM-UHFFFAOYSA-N > <FORMULA> C13H8O4 > <MOLECULAR_WEIGHT> 228.2002 > <EXACT_MASS> 228.042258744 > <JCHEM_ACCEPTOR_COUNT> 3 > <JCHEM_ATOM_COUNT> 25 > <JCHEM_AVERAGE_POLARIZABILITY> 22.258403045305855 > <JCHEM_BIOAVAILABILITY> 1 > <JCHEM_DONOR_COUNT> 2 > <JCHEM_FORMAL_CHARGE> 0 > <JCHEM_GHOSE_FILTER> 1 > <JCHEM_IUPAC> 3,8-dihydroxy-6H-benzo[c]chromen-6-one > <ALOGPS_LOGP> 2.16 > <JCHEM_LOGP> 2.318196798 > <ALOGPS_LOGS> -2.94 > <JCHEM_MDDR_LIKE_RULE> 0 > <JCHEM_NUMBER_OF_RINGS> 3 > <JCHEM_PHYSIOLOGICAL_CHARGE> 0 > <JCHEM_PKA> 7.9637712310585735 > <JCHEM_PKA_STRONGEST_ACIDIC> 7.213762400702427 > <JCHEM_PKA_STRONGEST_BASIC> -7.061837521358001 > <JCHEM_POLAR_SURFACE_AREA> 66.76 > <JCHEM_REFRACTIVITY> 60.90090000000001 > <JCHEM_ROTATABLE_BOND_COUNT> 0 > <JCHEM_RULE_OF_FIVE> 1 > <ALOGPS_SOLUBILITY> 2.63e-01 g/l > <JCHEM_TRADITIONAL_IUPAC> 3,8-dihydroxybenzo[c]chromen-6-one > <JCHEM_VEBER_RULE> 0 $$$$
Description	Metabolite of ellagic acid
Classification	Compounds > Chemical entities > Organic compounds > Phenylpropanoids and polyketides > Coumarins and derivatives
CAS number	1143-70-0
PubChem ID	5488186
ChEBI ID
FooDB ID	FDB029999
HMDB ID	HMDB0013695

Chemical data

MolDBi data

IUPAC Name	3,8-dihydroxy-6H-benzo[c]chromen-6-one
Traditional IUPAC Name	3,8-dihydroxybenzo[c]chromen-6-one
Formula	C13H8O4
InChI	InChI=1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H
InChI Key	RIUPLDUFZCXCHM-UHFFFAOYSA-N
Molecular weight	228.2002
Exact mass	228.042258744
SMILES	OC1=CC2=C(C=C1)C1=C(C=C(O)C=C1)C(=O)O2

ClassyFire Taxonomy

Description	belongs to the class of organic compounds known as coumarins and derivatives. These are polycyclic aromatic compounds containing a 1-benzopyran moiety with a ketone group at the C2 carbon atom (1-benzopyran-2-one).
Kingdom	Organic compounds
Super Class	Phenylpropanoids and polyketides
Class	Coumarins and derivatives
Sub Class	Not Available
Direct Parent	Coumarins and derivatives
Alternative Parents	Isocoumarins and derivatives 2-benzopyrans 1-benzopyrans Pyranones and derivatives 1-hydroxy-2-unsubstituted benzenoids Heteroaromatic compounds Lactones Oxacyclic compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives

Publications with Urolithin A

ID	Title	First author	Authors	Year	Journal	Volume	Issue	Pages	PubMed ID	DOI	Study design	No. of Biomarkers	No. of Intake values	No. of Concentration values	No. of Reproducibility values	No. of Correlation values	No. of Metabolomic associations	No. of Microbiota associations	No. of Cancer associations

Biomarker data

Measurements of Urolithin A in biospecimens

Concentration values

ID	Parent ID	Depth	Subject group	Population	Country	Cohort	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Measurement size	Detected (nb)	Detected (%)	Detected only?	Arithmethic mean	Arithmethic SD	Geometric mean	Geometric SD	Min	Min (detected)	Percentile_05	Percentile_10	Percentile_25	Median	Percentile_75	Percentile_90	Percentile_95	Max	Interquartile range	Mean 95% CI lower	Mean 95% CI upper	GMean 95% CI lower	GMean 95% CI upper	Unit	Converted arithmetic mean	Converted geometric mean	Converted median	Converted unit	Adjustment type	Adjusted on	Regressed on	Expressed as	Publication

Reproducibility values

ID	Excretion ID	Subject group	Population	Country	Cohort	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Arithmetic mean	Geometric mean	Median	Unit	Adjusted on	Reproducibility size	ICC	ICC 95% CI lower	ICC 95% CI upper	CV% WS	CV% BS	VAR WS	VAR BS	Publication

Associations of Urolithin A with exposures

Correlation values

ID	Intake ID	Excretion ID	Subject group	Population	Country	Cohort	Intake Time definition	Intake Assessment method	Intake	Intake detail	Supplement intakes included?	Intake Arithmetic mean	Intake Geometric mean	Intake Median	Intake Unit	Intake Adjusted on	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Biomarker Arithmetic mean	Biomarker Geometric mean	Biomarker Median	Biomarker Unit	Biomarker Adjusted on	Correlation size	Correlation type	Correlation value	Correlation 95% CI lower	Correlation 95% CI upper	Correlation p-value	Significant?	Measurement adjustment	Deattenuated?	Covariates	Publication

Metabolomic associations

ID	Intake ID	Excretion ID	Subject group	Population	Country	Cohort	No. of subjects	Intake Assessment method	Intake	Intervention dose	Biospecimen	Analytical method	Biomarker	Structural identification	Feature selection	Area under curve	Sensitivity	Specificity	PLS-DA VIP	Beta coefficient	Beta coefficient p-value	ANOVA p-value	Publication

Microbiota associations

ID	Biomarker	Experimental evidence	Organism	Biospecimen	Antibiotic	Bacterial source	Substrate	Publication

Associations of Urolithin A with cancer risk

Cancer associations

ID	Excretion ID	Subject group	Population	Country	Cohort	No. of subjects	No. of cases	No. of controls	Biospecimen	Analytical method	Biomarker	Biomarker detail	Cancer	Study design	Publication

Exposure data

Measurements of Urolithin A exposures in populations

Intake values

ID	Parent ID	Depth	Subject group	Population	Country	Cohort	Intake Time definition	Intake assessment tool	Intake food coverage	Intake time coverage	Intake Assessment method	Intake	Intake detail	Food description	Supplement intakes included?	Measurement size	Detected (nb)	Detected (%)	Detected only?	Arithmethic mean	Arithmethic SD	Geometric mean	Geometric SD	Min	Min (detected)	Percentile_05	Percentile_10	Percentile_25	Median	Percentile_75	Percentile_90	Percentile_95	Max	Interquartile range	Mean 95% CI lower	Mean 95% CI upper	GMean 95% CI lower	GMean 95% CI upper	Unit	Converted arithmetic mean	Converted geometric mean	Converted median	Converted unit	Adjustment type	Adjusted on	Regressed on	Expressed as	Publication

Associations of Urolithin A exposures with biomarkers

Correlation values

ID	Intake ID	Excretion ID	Subject group	Population	Country	Cohort	Intake Time definition	Intake Assessment method	Intake	Intake detail	Supplement intakes included?	Intake Arithmetic mean	Intake Geometric mean	Intake Median	Intake Unit	Intake Adjusted on	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Biomarker Arithmetic mean	Biomarker Geometric mean	Biomarker Median	Biomarker Unit	Biomarker Adjusted on	Correlation size	Correlation type	Correlation value	Correlation 95% CI lower	Correlation 95% CI upper	Correlation p-value	Significant?	Measurement adjustment	Deattenuated?	Covariates	Publication