Enterolactone

ID31
NameEnterolactone
Synonyms(-)-Enterolactone
StructureThumb
DescriptionMostly measured after enzymatic hydrolysis.
GroupPolyphenols
Sub-groupLignans
Exposure sourceDiet
Use
CAS number78473-71-9
PubChem ID10685477
ChEBI ID81555
FooDB IDFDB002488
HMDB IDHMDB06101

Biomarker measurements

Biomarker concentration values

IDParent IDDepthSubject groupPopulationCountryCountry codeCohortTime definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianAdjustment typeAdjusted onRegressed onExpressed asPublication
1890AllCases and controls undergoing endoscopy in a case-control study on colorectal adenomasNetherlandsNLPOLIEP (Case-control study on colorectal adenomas)Plasma, non-fastingLC-MS/MS after enzymatic hydrolysisEnterolactone63711.310.212.5nmol/L11.3 nmol/LCrudeMilder 2007
7327342AllPremenopausal womenCanadaCAProspective study investigating risk factors for osteoporosisUrine, 24-hGC-MS after enzymatic hydrolysisEnterolactone2613.220.80.04.690.5umol/day13.2 umol/day4.6 umol/dayCrudeFrench 2007
25300AllMidle-aged and elderly womenChinaCNSWHS (Shanghai Women's Health Study)Urine, spotLC-MS/MS after enzymatic hydrolysisEnterolactone21650.340.00.00.1090.171.184.1910.8717.4988.540.270.42nmol/mg0.3 umol/g1.2 umol/gDensityCreatinineWu 2012
39650All [by intake]Adults living in the Parisian areaFranceFRSU.VI.MAX (SUpplementation en VItamines et Mineraux AntioXydants)Urine, 24-hLC-MS/MS after enzymatic hydrolysisEnterolactone5323.926.6umol/day23.9 umol/dayCrudeMennen 2006
39810All [by intake]Adults living in the Parisian areaFranceFRSU.VI.MAX (SUpplementation en VItamines et Mineraux AntioXydants)Urine, first morning spotLC-MS/MS after enzymatic hydrolysisEnterolactone5310.78.8umol/L10700.0 nmol/LCrudeMennen 2006
47510AllControls in a case-control study on diet and breast cancerUnited KingdomGBPlasma, fastingTime-resolved fluoroimmunoassay (TR-FIA) after enzymatic hydrolysisEnterolactone5813.718.8nmol/L13.7 nmol/LCrudeBhakta 2005
480348131AllCases and controls in a case-control study on breast cancer and dietUnited KingdomGBEPIC-Norfolk (European Prospective Investigation into Cancer and Nutrition)Urine, spotGC-ID-MS after enzymatic hydrolysisEnterolactone33378.53.740.493.5193.39790.9ug/mmol78500.0 ug/mol93500.0 ug/molDensityCreatinineGrace 2004
481048151AllCases and controls in a case-control study on breast cancer and dietUnited KingdomGBEPIC-Norfolk (European Prospective Investigation into Cancer and Nutrition)Serum, unspecifiedLC-ID-MS/MS after enzymatic hydrolysisEnterolactone2843.83.62.34.58.7388.1ng/mL0.0 mg/L0.0 mg/LCrudeGrace 2004
56030MalesAdultsFinlandFIFINDIET (The 1997 Dietary Survey of Finnish Adults)Serum, unspecifiedTime-resolved fluoroimmunoassay (TR-FIA) after enzymatic hydrolysisEnterolactone92617.8nmol/L17.8 nmol/LCrudeKilkkinen 2003
56040FemalesAdultsFinlandFIFINDIET (The 1997 Dietary Survey of Finnish Adults)Serum, unspecifiedTime-resolved fluoroimmunoassay (TR-FIA) after enzymatic hydrolysisEnterolactone85820.7nmol/L20.7 nmol/LCrudeKilkkinen 2003
66680AllAdults in Seattle areaUnited StatesUSPlasma, fastingTime-resolved fluoroimmunoassay (TR-FIA) after enzymatic hydrolysisEnterolactone19313.9715.950.6155.3nmol/L14.0 nmol/LCrudeHorner 2002
693769402All [by intake]Members of the University of Minnesota communityUnited StatesUSUrine, 24-hGC-MS after enzymatic hydrolysisEnterolactone983.644.592.122.250.1432.75umol/day3.6 umol/day2.1 umol/dayCrudeLampe 1999
695769602High intake (Vegetables and fruits intake: ≥ 5 servings/day)Members of the University of Minnesota communityUnited StatesUSUrine, 24-hGC-MS after enzymatic hydrolysisEnterolactone492.532.84umol/day2.5 umol/dayCrudeLampe 1999
696769702Low intake (Vegetables and fruits intake: ≤ 2 servings/day)Members of the University of Minnesota communityUnited StatesUSUrine, 24-hGC-MS after enzymatic hydrolysisEnterolactone491.771.73umol/day1.8 umol/dayCrudeLampe 1999
186460AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedLC-MS/MS after enzymatic hydrolysisEnterolactone403.14.147.0nmol/L4.1 nmol/LCrudeKotsopoulos 2010
186540AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-MS/MS after enzymatic hydrolysisEnterolactone450.061.447.07nmol/mg1.4 umol/gDensityCreatinineKotsopoulos 2010
186740AllStudents of Helsinki UniversityFinlandFIbaseline; 1 day; 2 days; 3 days; 4 days; one week; 2 weeks; 3 weeksUrine, 24-hTime-resolved fluoroimmunoassay (TR-FIA) after enzymatic hydrolysisEnterolactone192460.0nmol/day2.5 umol/dayCrudeStumpf 2003
186770AllStudents of Helsinki UniversityFinlandFIbaseline; 1 day; 2 days; 3 days; 4 days; one week; 2 weeks; 3 weeksUrine, spotTime-resolved fluoroimmunoassay (TR-FIA) after enzymatic hydrolysisEnterolactone18289.0umol/mol289.0 umol/molDensityCreatinineStumpf 2003
186800AllStudents of Helsinki UniversityFinlandFIbaseline; 1 day; 2 days; 3 days; 4 days; one week; 2 weeks; 3 weeksSerum, fastingTime-resolved fluoroimmunoassay (TR-FIA) after enzymatic hydrolysisEnterolactone199.1nmol/L9.1 nmol/LCrudeStumpf 2003
186930AllMinority childrenUnited StatesUSbaseline; 2 weeks; 1 month; 2 months, 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisEnterolactone35314.216.5366.21529.05136.3ug/g314.2 ug/g366.2 ug/gDensityCreatinineTeitelbaum 2008
189110AllWomenSwedenSEMalmo Diet and Cancer cohortday 1; day 2; day 3Serum, non-fastingTime-resolved fluoroimmunoassay (TR-FIA) after enzymatic hydrolysisEnterolactone211.318.082.0nmol/L18.0 nmol/LCrudeSonestedt 2008
189120AllWomenSwedenSEMalmo Diet and Cancer cohortday 4; day 5Serum, fastingTime-resolved fluoroimmunoassay (TR-FIA) after enzymatic hydrolysisEnterolactone210.522.065.0nmol/L22.0 nmol/LCrudeSonestedt 2008
189260AllWomenUnited StatesUSNYUWHS (New York University Women's Health Study)baseline; 1 year; 2 yearsSerum, unspecifiedGC-MS after enzymatic hydrolysisEnterolactone6020.2nmol/L20.2 nmol/LCrudeZeleniuch-Jacquotte 1998
189340AllWomenUnited StatesUSNYUWHS (New York University Women's Health Study)baselineSerum, unspecifiedGC-MS after enzymatic hydrolysisEnterolactone6097.00.189.6222.539.8561.0nmol/L22.5 nmol/LCrudeZeleniuch-Jacquotte 1998
197710AllGirls from New York City, New York, Cincinnati, Ohio, and northern CaliforniaUnited StatesUSUrine, spotLC-MS/MS after enzymatic hydrolysisEnterolactone90100.0269.04.14.6298.06730.0ug/L0.3 mg/L0.3 mg/LCrudeWolff 2007

Intake values

No data available

Correlation values

Reproducibility values

IDMst. IDSubject groupPopulationCountryCountry codeCohortTime definitionBiological specimenExperimental methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication
30218646AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedLC-MS/MS after enzymatic hydrolysisEnterolactone4.1nmol/L400.440.220.6861.254.9Kotsopoulos 2010
30618654AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-MS/MS after enzymatic hydrolysisEnterolactone1.44nmol/mgCreatinine450.520.310.7295.3100.0Kotsopoulos 2010
31618675AllStudents of Helsinki UniversityFinlandFIbaseline; 1 week; 2 weeks; 3 weeksUrine, 24-hTime-resolved fluoroimmunoassay (TR-FIA) after enzymatic hydrolysisEnterolactonenmol/day190.80.670.91Stumpf 2003
31718676AllStudents of Helsinki UniversityFinlandFIbaseline; 1 day; 2 days; 3 days; 4 daysUrine, 24-hTime-resolved fluoroimmunoassay (TR-FIA) after enzymatic hydrolysisEnterolactonenmol/day190.790.640.9Stumpf 2003
31818678AllStudents of Helsinki UniversityFinlandFIbaseline; 1 week; 2 weeks; 3 weeksUrine, spotTime-resolved fluoroimmunoassay (TR-FIA) after enzymatic hydrolysisEnterolactoneumol/molCreatinine180.720.550.86Stumpf 2003
31918679AllStudents of Helsinki UniversityFinlandFIbaseline; 1 day; 2 days; 3 days; 4 daysUrine, spotTime-resolved fluoroimmunoassay (TR-FIA) after enzymatic hydrolysisEnterolactoneumol/molCreatinine180.670.460.84Stumpf 2003
32018681AllStudents of Helsinki UniversityFinlandFIbaseline; 1 week; 2 weeks; 3 weeksSerum, fastingTime-resolved fluoroimmunoassay (TR-FIA) after enzymatic hydrolysisEnterolactonenmol/L190.790.650.9Stumpf 2003
32118682AllStudents of Helsinki UniversityFinlandFIbaseline; 1 day; 2 days; 3 days; 4 daysSerum, fastingTime-resolved fluoroimmunoassay (TR-FIA) after enzymatic hydrolysisEnterolactonenmol/L190.770.610.89Stumpf 2003
34818693AllMinority childrenUnited StatesUSbaseline; 2 weeks; 1 month; 2 months, 3 months; 6 monthsUrine, spotLC-MS/MS after enzymatic hydrolysisEnterolactone314.2366.2ug/gCreatinine350.420.630.45Teitelbaum 2008
51618911AllWomenSwedenSEMalmo Diet and Cancer cohortday 1; day 2; day 3Serum, non-fastingTime-resolved fluoroimmunoassay (TR-FIA) after enzymatic hydrolysisEnterolactone18.0nmol/L210.480.220.7271.067.0Sonestedt 2008
51718912AllWomenSwedenSEMalmo Diet and Cancer cohortday 4; day 5Serum, fastingTime-resolved fluoroimmunoassay (TR-FIA) after enzymatic hydrolysisEnterolactone22.0nmol/L210.660.350.8459.089.0Sonestedt 2008
53118926AllWomenUnited StatesUSNYUWHS (New York University Women's Health Study)baseline; 1 year; 2 yearsSerum, unspecifiedGC-MS after enzymatic hydrolysisEnterolactone20.2nmol/L600.550.410.690.8010.973Zeleniuch-Jacquotte 1998
62619097AllSmall intervention study administering flaxseedGermanyDEbaseline; 1 week; 3 weeksPlasma, fastingTime-resolved fluoroimmunoassay (TR-FIA) after enzymatic hydrolysisEnterolactonenmol/L70.410.97Linseisen 2008