Homocysteine

ID336
NameHomocysteine
SynonymsTotal homocysteine (tHcy); L-Homocysteine
StructureThumb
DescriptionThe only dietary precursor of homocysteine is the essential amino acid methionine. Used for validation of folate FFQ (e.g. Yoshino2010), inverse correlations with folate intake.
GroupAmino acids
Sub-groupNon-proteinogenic amino acids
Exposure sourceDiet
Use
CAS number6027-13-0
PubChem ID91552
ChEBI ID17588
FooDB IDFDB001491
HMDB IDHMDB00742

Biomarker measurements

Biomarker concentration values

IDParent IDDepthSubject groupPopulationCountryCountry codeCohortTime definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianAdjustment typeAdjusted onRegressed onExpressed asPublication
32000AllElderly participants in three folate supplementation studiesNetherlandsNLPlasma, fastingHPLCHomocysteine128112.63.1umol/L12600.0 nmol/LCrudevan de Rest 2007
32050FACIT-StudyElderly participants in three folate supplementation studiesNetherlandsNLFACIT (Folic Acid and Carotid Intima-media Thickness)Plasma, fastingHPLCHomocysteine81913.32.9umol/L13300.0 nmol/LCrudevan de Rest 2007
32100CHEF-StudyElderly participants in three folate supplementation studiesNetherlandsNLCHEFPlasma, fastingHPLCHomocysteine15710.92.8umol/L10900.0 nmol/LCrudevan de Rest 2007
32150Dolfin-StudyElderly participants in three folate supplementation studiesNetherlandsNLDolfinPlasma, fastingHPLCHomocysteine30511.63.0umol/L11600.0 nmol/LCrudevan de Rest 2007
204910AllWomen from the university communityUnited StatesUSPlasma, semi-fastingHPLCHomocysteine285.61.23.48.8umol/L5600.0 nmol/LCrudeYen 2003

Intake values

No data available

Correlation values

Reproducibility values

IDMst. IDSubject groupPopulationCountryCountry codeCohortTime definitionBiological specimenExperimental methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication
61119082AllDutch participants of the EPIC-StudyNetherlandsNLMORGEN-EPIC projectbaseline; 3 yearsSerum, non-fastingColorimetryHomocysteinenmol/L600.90.850.93Leenders 2013