ID489
NameFolates
SynonymsFolic acid; Folate; Total folate; Folates, natural and synthetic; Folates, natural and added
StructureThumb
DescriptionIncludes natural folate (foods) and added folic acid (foods and/or supplements).
ClassificationCompounds > Diet > Vitamins > Vitamin B > Vitamin B9 (Folic acid)
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Publications with Folates

TitleFirst authorYear
Validity and reproducibility of folate and vitamin B(12) intakes estimated from a self-administered diet history questionnaire in Japanese pregnant womenShiraishi2012
Twenty-four hour urinary water-soluble vitamin levels correlate with their intakes in free-living Japanese schoolchildrenTsuji2011
Effect of cooking loss in the assessment of vitamin intake for epidemiological data in JapanKobayashi2011
Twenty-four-hour urinary water-soluble vitamin levels correlate with their intakes in free-living Japanese university studentsTsuji2010
Validity of food frequency questionnaire estimated intakes of folate and other B vitamins in a region without folic acid fortificationJohansson2010
Reliability and validity of food frequency questionnaire and nutrient biomarkers in elders with and without mild cognitive impairmentBowman2011
Urinary excretion of vitamin B1, B2, B6, niacin, pantothenic acid, folate, and vitamin C correlates with dietary intakes of free-living elderly, female JapaneseTsuji2010
Biochemical validation of food frequency questionnaire-estimated carotenoid, a-Tocopherol, and folate intakes among African Americans and non-Hispanic Whites in the Southern Community Cohort StudySignorello2010
Validation of a food choice map with a 3-day food record and serum values to assess folate and vitamin B-12 intake in college-aged womenShuaibi2008
Validation of the assessment of folate and vitamin B12 intake in women of reproductive age: the method of triadsVerkleij-Hagoort2007
Comparison of two dietary folate intake instruments and their validation by RBC folateOwens2007
Validation of a food frequency questionnaire to assess folate intake of Dutch elderly peoplevan de Rest2007
Relative validity of a food frequency questionnaire used in the Inter99 studyToft2008
Evaluating associations between Mediterranean diet adherence indexes and biomarkers of diet and diseaseBach-Faig2006
Validity of protein, retinol, folic acid and n–3 fatty acid intakes estimated from the food-frequency questionnaire used in the Danish National Birth CohortMikkelsen2006
Dietary evaluation and attenuation of relative risk: multiple comparisons between blood and urinary biomarkers, food frequency, and 24-hour recall questionnaires: the DEARR studyShai2005
Validation of a semiquantitative food frequency questionnaire to assess folate status. Results discriminate a high-risk group of women residing on the Mexico-US borderBacardi-Gascon2003
Validation of a short food frequency questionnaire to assess folate intakePufulete2002
Folate intake assessment: validation of a new approachYen2003
Application of the method of triads to evaluate the performance of food frequency questionnaires and biomarkers as indicators of long-term dietary intakeKabagambe2001
Comparing biological measurements of vitamin C, folate, alpha-tocopherol and carotene with 24-hour dietary recall information in nonhispanic blacks and whitesKnutsen2001
Dietary assessment in Whitehall II: comparison of 7 d diet diary and food-frequency questionnaire and validity against biomarkersBrunner2001
A three-day weighed food record and a semiquantitative food-frequency questionnaire are valid measures for assessing the folate and vitamin B-12 intakes of women aged 16 to 19 yearsGreen1998
Comparison of micronutrient intake measured by a dietary questionnaire and biochemical indicators of micronutrient statusJacques1993
Reliability of selected antioxidants and compounds involved in one-carbon metabolism in two Dutch cohortsLeenders2013
Intra- and inter-individual variations of blood and urinary water-soluble vitamins in Japanese young adults consuming a semi-purified diet for 7 daysShibata2009
A prospective study of one-carbon metabolism biomarkers and risk of renal cell carcinomaGibson2010
Prospective study of serum B vitamins levels and oesophageal and gastric cancers in ChinaRen2016
Prospective association between dietary folate intake and skin cancer risk: results from the Supplementation en Vitamines et Mineraux Antioxydants cohortDonnenfeld2015
Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohortMatejcic2017
Plasma Riboflavin and Vitamin B-6, but Not Homocysteine, Folate, or Vitamin B-12, Are Inversely Associated with Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition-Varese CohortAgnoli2016
Red blood cell folate and plasma folate are not associated with risk of incident colorectal cancer in the Women's Health Initiative observational studyNeuhouser2015
Plasma folate concentrations and colorectal cancer risk: a case-control study nested within the Shanghai Men's Health StudyTakata2014
Alcohol consumption, one-carbon metabolites, liver cancer and liver disease mortalitySchwartz2013
Serum folate and vitamin B12 concentrations in relation to prostate cancer risk--a Norwegian population-based nested case-control study of 3000 cases and 3000 controls within the JANUS cohortde Vogel2013
A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and NutritionChuang2011
Serum B vitamin levels and risk of lung cancerJohansson2010
Plasma folate, related genetic variants, and colorectal cancer risk in EPICEussen2010
Plasma folate concentrations are positively associated with risk of estrogen receptor beta negative breast cancer in a Swedish nested case control studyEricson2010
Dietary B vitamin and methionine intakes and plasma folate are not associated with colorectal cancer risk in Chinese womenShrubsole2009
Plasma levels of B vitamins and colorectal cancer risk: the multiethnic cohort studyLe Marchand2009
One-carbon metabolism biomarkers and risk of colon and rectal cancersWeinstein2008
Plasma folate and risk of colorectal cancer in a nested case-control study: the Japan Public Health Center-based prospective studyOtani2008
Plasma folate, vitamin B-6, vitamin B-12, and risk of breast cancer in womenLin2008
Circulating concentrations of folate and vitamin B12 in relation to prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition studyJohansson2008
The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and NutritionVollset2007
Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancerZhang2003
Null association between prostate cancer and serum folate, vitamin B(6), vitamin B(12), and homocysteineWeinstein2003
Association of the B-vitamins pyridoxal 5'-phosphate (B(6)), B(12), and folate with lung cancer risk in older menHartman2001
The risk of cervical cancer in relation to serum concentrations of folate, vitamin B12, and homocysteineAlberg2000
Pancreatic cancer risk and nutrition-related methyl-group availability indicators in male smokersStolzenberg-Solomon1999
Serum folate, homocysteine and colorectal cancer risk in women: a nested case-control studyKato1999
Colorectal cancer and folate status: a nested case-control study among male smokersGlynn1996
Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective studyHultdin2005
Untangling the role of one-carbon metabolism in colorectal cancer risk: a comprehensive Bayesian network analysisMyte2017
Low folate levels are associated with reduced risk of colorectal cancer in a population with low folate statusGylling2014
Plasma vitamin B12 concentrations and the risk of colorectal cancer: a nested case-referent studyDahlin2008
Low folate levels may protect against colorectal cancerVan Guelpen2006
Circulating Folate, Vitamin B6, and Methionine in Relation to Lung Cancer Risk in the Lung Cancer Cohort Consortium (LC3)Fanidi2018
A prospective study on folate, B12, and pyridoxal 5'-phosphate (B6) and breast cancerWu1999
A prospective study of one-carbon metabolism biomarkers and cancer of the head and neck and esophagusFanidi2015
Low vitamin B12 increases risk of gastric cancer: A prospective study of one-carbon metabolism nutrients and risk of upper gastrointestinal tract cancerMiranti2017
Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survivalJohansson2014
Plasma folate, methylenetetrahydrofolate reductase (MTHFR), and colorectal cancer risk in three large nested case-control studiesLee2012
Circulating Folate and Vitamin B12 and Risk of Prostate Cancer: A Collaborative Analysis of Individual Participant Data from Six Cohorts Including 6875 Cases and 8104 ControlsPrice2016
Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohortsSchernhammer2007
Plasma folate, vitamin B-6, and vitamin B-12 and breast cancer risk in BRCA1- and BRCA2-mutation carriers: a prospective studyKim2016

Biomarker data

Measurements of Folates in biospecimens

Concentration values

IDParent IDDepthSubject groupPopulationCountryCohortBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianConverted unitAdjustment typeAdjusted onRegressed onExpressed asPublication

Reproducibility values

IDExcretion IDSubject groupPopulationCountryCohortBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication

Associations of Folates with exposures

Correlation values

IDIntake IDExcretion IDSubject groupPopulationCountryCohortIntake Time definitionIntake Assessment methodIntakeIntake detailSupplement intakes included?Intake Arithmetic meanIntake Geometric meanIntake MedianIntake UnitIntake Adjusted onBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailBiomarker Arithmetic meanBiomarker Geometric meanBiomarker MedianBiomarker UnitBiomarker Adjusted onCorrelation sizeCorrelation typeCorrelation valueCorrelation 95% CI lowerCorrelation 95% CI upperCorrelation p-valueSignificant?Measurement adjustmentDeattenuated?CovariatesPublication

Metabolomic associations

IDIntake IDExcretion IDSubject groupPopulationCountryCohortNo. of subjectsIntake Assessment methodIntakeIntervention doseBiospecimenAnalytical methodBiomarkerStructural identificationFeature selectionArea under curveSensitivitySpecificityPLS-DA VIPBeta coefficientBeta coefficient p-valueANOVA p-valuePublication

Associations of Folates with cancer risk

Cancer associations

IDExcretion IDSubject groupPopulationCountryCohortNo. of subjectsNo. of casesNo. of controlsBiospecimenAnalytical methodBiomarkerBiomarker detailCancerStudy designPublication

Exposure data

Measurements of Folates exposures in populations

Intake values

IDParent IDDepthSubject groupPopulationCountryCohortIntake Time definitionIntake assessment toolIntake food coverageIntake time coverageIntake Assessment methodIntakeIntake detailFood descriptionSupplement intakes included?Measurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianConverted unitAdjustment typeAdjusted onRegressed onExpressed asPublication

Associations of Folates exposures with biomarkers

Correlation values

IDIntake IDExcretion IDSubject groupPopulationCountryCohortIntake Time definitionIntake Assessment methodIntakeIntake detailSupplement intakes included?Intake Arithmetic meanIntake Geometric meanIntake MedianIntake UnitIntake Adjusted onBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailBiomarker Arithmetic meanBiomarker Geometric meanBiomarker MedianBiomarker UnitBiomarker Adjusted onCorrelation sizeCorrelation typeCorrelation valueCorrelation 95% CI lowerCorrelation 95% CI upperCorrelation p-valueSignificant?Measurement adjustmentDeattenuated?CovariatesPublication