25-Hydroxycholecalciferol

ID578
Name25-Hydroxycholecalciferol
Synonyms[Vitamin D] / Calcidiol; Calcifediol; 25-OH-Vitamin D; Vitamin D (in blood)
StructureThumb
DescriptionMetabolite of vitamin D3 (cholecalciferol). Major circulating form of vitamin D, prehormone. Laboratory test for vitamin D status.
GroupSteroids
Sub-groupHydroxy seco-steroids
Exposure sourceDiet
UseVitamins
CAS number19356-17-3
PubChem ID5283731
ChEBI ID17933
FooDB IDFDB021782
HMDB IDHMDB03550

Biomarker measurements

Biomarker concentration values

IDParent IDDepthSubject groupPopulationCountryCountry codeCohortTime definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianAdjustment typeAdjusted onRegressed onExpressed asPublication
81720Young malesParticipants in a vitamin K metabolic study in New England regionUnited StatesUSPlasma, fastingHPLC25-Hydroxycholecalciferol995.0nmol/L95.0 nmol/LCrudeBooth 1997
81760Young femalesParticipants in a vitamin K metabolic study in New England regionUnited StatesUSPlasma, fastingHPLC25-Hydroxycholecalciferol870.0nmol/L70.0 nmol/LCrudeBooth 1997
81800Old malesParticipants in a vitamin K metabolic study in New England regionUnited StatesUSPlasma, fastingHPLC25-Hydroxycholecalciferol9108.0nmol/L108.0 nmol/LCrudeBooth 1997
81840Old femalesParticipants in a vitamin K metabolic study in New England regionUnited StatesUSPlasma, fastingHPLC25-Hydroxycholecalciferol878.0nmol/L78.0 nmol/LCrudeBooth 1997
88460AllElderly women of high socioeconomic status residant in a housing complexUnited StatesUSPlasma, fastingChemiluminescence protein binding assay25-Hydroxycholecalciferol5963.4nmol/L63.4 nmol/LCrudeSalamone 1994
88470AllElderly women of high socioeconomic status residant in a housing complexUnited StatesUSPlasma, fastingChemiluminescence protein binding assay25-Hydroxycholecalciferol5954.7nmol/L54.7 nmol/LCrudeSalamone 1994
88560Low sunlight exposure - Low vit D intake (Vitamin D intake: 1 to 8.03 ug/day)Elderly women of high socioeconomic status residant in a housing complexUnited StatesUSPlasma, fastingChemiluminescence protein binding assay25-Hydroxycholecalciferol1344.0nmol/L44.0 nmol/LCrudeSalamone 1994
88570Low sunlight exposure - Low vit D intake (Vitamin D intake: 1 to 8.03 ug/day)Elderly women of high socioeconomic status residant in a housing complexUnited StatesUSPlasma, fastingChemiluminescence protein binding assay25-Hydroxycholecalciferol1335.0nmol/L35.0 nmol/LCrudeSalamone 1994
88580Low sunlight exposure - High vit D intake (Vitamin D intake: 11.15 to 28.68 ug/day)Elderly women of high socioeconomic status residant in a housing complexUnited StatesUSPlasma, fastingChemiluminescence protein binding assay25-Hydroxycholecalciferol1380.0nmol/L80.0 nmol/LCrudeSalamone 1994
88590Low sunlight exposure - High vit D intake (Vitamin D intake: 11.15 to 28.68 ug/day)Elderly women of high socioeconomic status residant in a housing complexUnited StatesUSPlasma, fastingChemiluminescence protein binding assay25-Hydroxycholecalciferol1381.0nmol/L81.0 nmol/LCrudeSalamone 1994
88600High sunlight exposure - Low vit D intake (Vitamin D intake: 1 to 8.03 ug/day)Elderly women of high socioeconomic status residant in a housing complexUnited StatesUSPlasma, fastingChemiluminescence protein binding assay25-Hydroxycholecalciferol1557.0nmol/L57.0 nmol/LCrudeSalamone 1994
88610High sunlight exposure - Low vit D intake (Vitamin D intake: 1 to 8.03 ug/day)Elderly women of high socioeconomic status residant in a housing complexUnited StatesUSPlasma, fastingChemiluminescence protein binding assay25-Hydroxycholecalciferol1542.0nmol/L42.0 nmol/LCrudeSalamone 1994
88620High sunlight exposure - High vit D intake (Vitamin D intake: 11.15 to 28.68 ug/day)Elderly women of high socioeconomic status residant in a housing complexUnited StatesUSPlasma, fastingChemiluminescence protein binding assay25-Hydroxycholecalciferol974.0nmol/L74.0 nmol/LCrudeSalamone 1994
88630High sunlight exposure - High vit D intake (Vitamin D intake: 11.15 to 28.68 ug/day)Elderly women of high socioeconomic status residant in a housing complexUnited StatesUSPlasma, fastingChemiluminescence protein binding assay25-Hydroxycholecalciferol964.0nmol/L64.0 nmol/LCrudeSalamone 1994
91460MalesParticipants in a case-control study of nutritional status and age-related cataractsUnited StatesUSPlasma, unspecifiedMissing25-Hydroxycholecalciferol5583.032.0nmol/L83.0 nmol/LCrudeJacques 1993
91560Males - Supplement nonusersParticipants in a case-control study of nutritional status and age-related cataractsUnited StatesUSPlasma, unspecifiedMissing25-Hydroxycholecalciferol4279.034.0nmol/L79.0 nmol/LCrudeJacques 1993
91660FemalesParticipants in a case-control study of nutritional status and age-related cataractsUnited StatesUSPlasma, unspecifiedMissing25-Hydroxycholecalciferol8073.031.0nmol/L73.0 nmol/LCrudeJacques 1993
91760Females - Supplement nonusersParticipants in a case-control study of nutritional status and age-related cataractsUnited StatesUSPlasma, unspecifiedMissing25-Hydroxycholecalciferol6670.031.0nmol/L70.0 nmol/LCrudeJacques 1993
183230AllPostmenopausal womenUnited StatesUSBuffalo Osteoporosis and Periodontal Disease Study, an ancillary study of the Women Health Initiative (WHI) Observation StudybaselinePlasma, fastingChemiluminescence immunoassay25-Hydroxycholecalciferol67260.022.25.9147.2nmol/L60.0 nmol/LCrudeMeng 2012
183240AllPostmenopausal womenUnited StatesUSBuffalo Osteoporosis and Periodontal Disease Study, an ancillary study of the Women Health Initiative (WHI) Observation Study5 yearsPlasma, fastingChemiluminescence immunoassay25-Hydroxycholecalciferol67267.822.213.0185.8nmol/L67.8 nmol/LCrudeMeng 2012
186560AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 1 year; 2 yearsPlasma, unspecifiedRadioimmunoassay25-Hydroxycholecalciferol7116.633.351.8ng/mL0.0 mg/LCrudeKotsopoulos 2010
186670AllAmericans of european and african descent in the southeastern USUnited StatesUSSCCS (Southern Community Cohort Study)baselineSerum, non-fastingChemiluminescence immunoassay25-Hydroxycholecalciferol23813.218.826.3ng/mL0.0 mg/LCrudeSonderman 2012
186680African AmericanAmericans of european and african descent in the southeastern USUnited StatesUSSCCS (Southern Community Cohort Study)baselineSerum, non-fastingChemiluminescence immunoassay25-Hydroxycholecalciferol15512.716.923.7ng/mL0.0 mg/LCrudeSonderman 2012
186690European AmericanAmericans of european and african descent in the southeastern USUnited StatesUSSCCS (Southern Community Cohort Study)baselineSerum, non-fastingChemiluminescence immunoassay25-Hydroxycholecalciferol7018.023.130.2ng/mL0.0 mg/LCrudeSonderman 2012
190630AllParticipants of a Cancer screening TrialUnited StatesUSPLCO (Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial)baselineSerum, non-fastingChemiluminescence immunoassay25-Hydroxycholecalciferol2960.014.633.760.299.6nmol/L60.0 nmol/L60.2 nmol/LCrudeHofmann 2010

Intake values

No data available

Correlation values

Reproducibility values

IDMst. IDSubject groupPopulationCountryCountry codeCohortTime definitionBiological specimenExperimental methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication
311767All [by diagnosis]Elderly subjects with and without mild cognitive impairmentUnited StatesUSbaseline; 1 monthPlasma, fastingHPLC25-Hydroxycholecalciferolmissing unit380.98Bowman 2011
541745No cognitive impairmentElderly subjects with and without mild cognitive impairmentUnited StatesUSbaseline; 1 monthPlasma, fastingHPLC25-Hydroxycholecalciferolmissing unit190.98Bowman 2011
761723Mild cognitive impairmentElderly subjects with and without mild cognitive impairmentUnited StatesUSbaseline; 1 monthPlasma, fastingHPLC25-Hydroxycholecalciferolmissing unit190.98Bowman 2011
13118535AllPostmenopausal womenUnited StatesUSBuffalo Osteoporosis and Periodontal Disease Study, an ancillary study of the Women Health Initiative (WHI) Observation Studybaseline; 5 yearsPlasma, fastingChemiluminescence immunoassay25-Hydroxycholecalciferolnmol/L6720.590.540.64Meng 2012
30718656AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 1 year; 2 yearsPlasma, unspecifiedRadioimmunoassay25-Hydroxycholecalciferol33.3ng/mL710.720.620.818.429.6Kotsopoulos 2010
30918659AllAmericans of european and african descent in the southeastern USUnited StatesUSSCCS (Southern Community Cohort Study)baseline; 1.7 yearsSerum, non-fastingChemiluminescence immunoassay25-Hydroxycholecalciferolng/mL2380.880.850.91Sonderman 2012
31018665African AmericanAmericans of european and african descent in the southeastern USUnited StatesUSSCCS (Southern Community Cohort Study)baseline; 1.7 yearsSerum, non-fastingChemiluminescence immunoassay25-Hydroxycholecalciferolng/mL1550.840.790.88Sonderman 2012
31118666European AmericanAmericans of european and african descent in the southeastern USUnited StatesUSSCCS (Southern Community Cohort Study)baseline; 1.7 yearsSerum, non-fastingChemiluminescence immunoassay25-Hydroxycholecalciferolng/mL700.970.960.98Sonderman 2012
59919062AllParticipants of a Cancer screening TrialUnited StatesUSPLCO (Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial)baseline; 1 year; 5 yearsSerum, non-fastingChemiluminescence immunoassay25-Hydroxycholecalciferolnmol/L290.710.630.88Hofmann 2010
60019064Non-Hispanic CaucasianParticipants of a Cancer screening TrialUnited StatesUSPLCO (Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial)baseline; 1 year; 5 yearsSerum, non-fastingChemiluminescence immunoassay25-Hydroxycholecalciferolnmol/L230.750.640.9Hofmann 2010