5-Hydroxyindole-3-acetic acid (Compound)

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ID	668
Name	5-Hydroxyindole-3-acetic acid
Synonyms	5-Hydroxyindoleacetic acid; Hydroxyindole acetic acid; 5-HIAA
Structure	MOL SDF PDB SMILES InChI Structure for EE000668 (5-Hydroxyindole-3-acetic acid) 3D Structure for EE000668 (5-Hydroxyindole-3-acetic acid) Mrv1652302032018292D 14 15 0 0 0 0 999 V2000 9997.0764 9999.4249 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9996.8215 9998.6402 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9997.3735 9998.0272 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9998.1805 9998.1986 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9998.295810000.3109 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 9997.8834 9999.5964 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9998.4354 9998.9833 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9999.1891 9999.3189 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9999.102810000.1393 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9999.9036 9998.9064 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10000.6180 9999.3189 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10001.3324 9998.9064 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 10000.618010000.1439 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 9997.1185 9997.2425 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2 0 0 0 0 2 3 1 0 0 0 0 3 4 2 0 0 0 0 6 7 2 0 0 0 0 7 8 1 0 0 0 0 8 9 2 0 0 0 0 5 6 1 0 0 0 0 5 9 1 0 0 0 0 8 10 1 0 0 0 0 4 7 1 0 0 0 0 6 1 1 0 0 0 0 10 11 1 0 0 0 0 11 12 1 0 0 0 0 11 13 2 0 0 0 0 3 14 1 0 0 0 0 M END > <DATABASE_ID> EE000668 > <DATABASE_NAME> ExposomeExplorer > <SMILES> OC(=O)CC1=CNC2=C1C=C(O)C=C2 > <INCHI_IDENTIFIER> InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14) > <INCHI_KEY> DUUGKQCEGZLZNO-UHFFFAOYSA-N > <FORMULA> C10H9NO3 > <MOLECULAR_WEIGHT> 191.1834 > <EXACT_MASS> 191.058243159 > <JCHEM_ACCEPTOR_COUNT> 3 > <JCHEM_ATOM_COUNT> 23 > <JCHEM_AVERAGE_POLARIZABILITY> 18.70645401922691 > <JCHEM_BIOAVAILABILITY> 1 > <JCHEM_DONOR_COUNT> 3 > <JCHEM_FORMAL_CHARGE> 0 > <JCHEM_GHOSE_FILTER> 1 > <JCHEM_IUPAC> 2-(5-hydroxy-1H-indol-3-yl)acetic acid > <ALOGPS_LOGP> 1.28 > <JCHEM_LOGP> 1.4061907766666666 > <ALOGPS_LOGS> -2.03 > <JCHEM_MDDR_LIKE_RULE> 0 > <JCHEM_NUMBER_OF_RINGS> 2 > <JCHEM_PHYSIOLOGICAL_CHARGE> -1 > <JCHEM_PKA> 9.558275552338404 > <JCHEM_PKA_STRONGEST_ACIDIC> 4.215990424188327 > <JCHEM_PKA_STRONGEST_BASIC> -5.50801830576937 > <JCHEM_POLAR_SURFACE_AREA> 73.32 > <JCHEM_REFRACTIVITY> 50.433 > <JCHEM_ROTATABLE_BOND_COUNT> 2 > <JCHEM_RULE_OF_FIVE> 1 > <ALOGPS_SOLUBILITY> 1.80e+00 g/l > <JCHEM_TRADITIONAL_IUPAC> hydroxyindoleacetic acid > <JCHEM_VEBER_RULE> 0 $$$$
Description	Metabolite of serotonin, produced by host (Fig 2, pmid:29902437). Main metabolite of serotonin.
Classification	Compounds > Chemical entities > Organic compounds > Organoheterocyclic compounds > Indoles and derivatives > Indolyl carboxylic acids and derivatives > Indole-3-acetic acid derivatives
CAS number	54-16-0
PubChem ID	1826
ChEBI ID	27823
FooDB ID	FDB001403
HMDB ID	HMDB0000763

Chemical data

MolDBi data

IUPAC Name	2-(5-hydroxy-1H-indol-3-yl)acetic acid
Traditional IUPAC Name	hydroxyindoleacetic acid
Formula	C10H9NO3
InChI	InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14)
InChI Key	DUUGKQCEGZLZNO-UHFFFAOYSA-N
Molecular weight	191.1834
Exact mass	191.058243159
SMILES	OC(=O)CC1=CNC2=CC=C(O)C=C12

ClassyFire Taxonomy

Description	belongs to the class of organic compounds known as indole-3-acetic acid derivatives. Indole-3-acetic acid derivatives are compounds containing an acetic acid (or a derivative) linked to the C3 carbon atom of an indole.
Kingdom	Organic compounds
Super Class	Organoheterocyclic compounds
Class	Indoles and derivatives
Sub Class	Indolyl carboxylic acids and derivatives
Direct Parent	Indole-3-acetic acid derivatives
Alternative Parents	Hydroxyindoles 3-alkylindoles 1-hydroxy-2-unsubstituted benzenoids Substituted pyrroles Heteroaromatic compounds Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds

Publications with 5-Hydroxyindole-3-acetic acid

ID	Title	First author	Authors	Year	Journal	Volume	Issue	Pages	PubMed ID	DOI	Study design	No. of Biomarkers	No. of Intake values	No. of Concentration values	No. of Reproducibility values	No. of Correlation values	No. of Metabolomic associations	No. of Microbiota associations	No. of Cancer associations

Biomarker data

Measurements of 5-Hydroxyindole-3-acetic acid in biospecimens

Concentration values

ID	Parent ID	Depth	Subject group	Population	Country	Cohort	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Measurement size	Detected (nb)	Detected (%)	Detected only?	Arithmethic mean	Arithmethic SD	Geometric mean	Geometric SD	Min	Min (detected)	Percentile_05	Percentile_10	Percentile_25	Median	Percentile_75	Percentile_90	Percentile_95	Max	Interquartile range	Mean 95% CI lower	Mean 95% CI upper	GMean 95% CI lower	GMean 95% CI upper	Unit	Converted arithmetic mean	Converted geometric mean	Converted median	Converted unit	Adjustment type	Adjusted on	Regressed on	Expressed as	Publication

Reproducibility values

ID	Excretion ID	Subject group	Population	Country	Cohort	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Arithmetic mean	Geometric mean	Median	Unit	Adjusted on	Reproducibility size	ICC	ICC 95% CI lower	ICC 95% CI upper	CV% WS	CV% BS	VAR WS	VAR BS	Publication

Associations of 5-Hydroxyindole-3-acetic acid with exposures

Correlation values

ID	Intake ID	Excretion ID	Subject group	Population	Country	Cohort	Intake Time definition	Intake Assessment method	Intake	Intake detail	Supplement intakes included?	Intake Arithmetic mean	Intake Geometric mean	Intake Median	Intake Unit	Intake Adjusted on	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Biomarker Arithmetic mean	Biomarker Geometric mean	Biomarker Median	Biomarker Unit	Biomarker Adjusted on	Correlation size	Correlation type	Correlation value	Correlation 95% CI lower	Correlation 95% CI upper	Correlation p-value	Significant?	Measurement adjustment	Deattenuated?	Covariates	Publication

Metabolomic associations

ID	Intake ID	Excretion ID	Subject group	Population	Country	Cohort	No. of subjects	Intake Assessment method	Intake	Intervention dose	Biospecimen	Analytical method	Biomarker	Structural identification	Feature selection	Area under curve	Sensitivity	Specificity	PLS-DA VIP	Beta coefficient	Beta coefficient p-value	ANOVA p-value	Publication

Microbiota associations

ID	Biomarker	Experimental evidence	Organism	Biospecimen	Antibiotic	Bacterial source	Substrate	Publication

Associations of 5-Hydroxyindole-3-acetic acid with cancer risk

Cancer associations

ID	Excretion ID	Subject group	Population	Country	Cohort	No. of subjects	No. of cases	No. of controls	Biospecimen	Analytical method	Biomarker	Biomarker detail	Cancer	Study design	Publication

Exposure data

Measurements of 5-Hydroxyindole-3-acetic acid exposures in populations

Intake values

ID	Parent ID	Depth	Subject group	Population	Country	Cohort	Intake Time definition	Intake assessment tool	Intake food coverage	Intake time coverage	Intake Assessment method	Intake	Intake detail	Food description	Supplement intakes included?	Measurement size	Detected (nb)	Detected (%)	Detected only?	Arithmethic mean	Arithmethic SD	Geometric mean	Geometric SD	Min	Min (detected)	Percentile_05	Percentile_10	Percentile_25	Median	Percentile_75	Percentile_90	Percentile_95	Max	Interquartile range	Mean 95% CI lower	Mean 95% CI upper	GMean 95% CI lower	GMean 95% CI upper	Unit	Converted arithmetic mean	Converted geometric mean	Converted median	Converted unit	Adjustment type	Adjusted on	Regressed on	Expressed as	Publication

Associations of 5-Hydroxyindole-3-acetic acid exposures with biomarkers

Correlation values

ID	Intake ID	Excretion ID	Subject group	Population	Country	Cohort	Intake Time definition	Intake Assessment method	Intake	Intake detail	Supplement intakes included?	Intake Arithmetic mean	Intake Geometric mean	Intake Median	Intake Unit	Intake Adjusted on	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Biomarker Arithmetic mean	Biomarker Geometric mean	Biomarker Median	Biomarker Unit	Biomarker Adjusted on	Correlation size	Correlation type	Correlation value	Correlation 95% CI lower	Correlation 95% CI upper	Correlation p-value	Significant?	Measurement adjustment	Deattenuated?	Covariates	Publication