Lutein/Zeaxanthin (Compound)

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ID838
NameLutein/Zeaxanthin
SynonymsLutein and Zeaxanthin; Lutein + Zeaxanthin; Lutein plus Zeaxanthin; Lutein; trans-Lutein/Zeaxanthin
StructureThumb
DescriptionCan abusively be called "lutein". This item is used when lutein and zeaxanthin coelute. It is used by default for the intakes unless "lutein only" is clearly stated.
ClassificationCompounds > Diet > Lipids > Carotenoids > Xanthophylls
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Publications with Lutein/Zeaxanthin

TitleFirst authorYear
Racial differences in correlations between reported dietary intakes of carotenoids and their concentration biomarkersArab2011
Reliability and validity of food frequency questionnaire and nutrient biomarkers in elders with and without mild cognitive impairmentBowman2011
Biochemical validation of food frequency questionnaire-estimated carotenoid, a-Tocopherol, and folate intakes among African Americans and non-Hispanic Whites in the Southern Community Cohort StudySignorello2010
Evaluation of an FFQ for assessment of antioxidant intake using plasma biomarkers in an ethnically diverse populationHodge2009
Validation of an antioxidant nutrient questionnaire in Whites and African AmericansSatia2009
Carotenoid, tocopherol, and fatty acid biomarkers and dietary intake estimated by using a brief self-administered diet history questionnaire for older Japanese children and adolescentsOkuda2009
Validation of overweight children's fruit and vegetable intake using plasma carotenoidsBurrows2009
Carotenoid intakes, assessed by food-frequency questionnaires (FFQs), are associated with serum carotenoid concentrations in the Jackson Heart Study: validation of the Jackson Heart Study Delta NIRI Adult FFQsTalegawkar2008
Site-specific concentrations of carotenoids in adipose tissue: relations with dietary and serum carotenoid concentrations in healthy adultsChung2009
Plasma concentrations of carotenoids and vitamin C are better correlated with dietary intake in normal weight than overweight and obese elderly subjectsVioque2007
Carotenoid and tocopherol estimates from the NCI diet history questionnaire are valid compared with multiple recalls and serum biomarkersDixon2006
Validation of a food-frequency questionnaire assessment of carotenoid and vitamin E intake using weighed food records and plasma biomarkers: the method of triads modelMcNaughton2005
Assessment of a dietary questionnaire in cancer patients receiving cytotoxic chemotherapyMeyerhardt2005
Reproducibility, validity, and responsiveness to change of a short questionnaire for measuring fruit and vegetable intakeBogers2004
Reasonable estimates of serum vitamin E, vitamin C, and beta-cryptoxanthin are obtained with a food frequency questionnaire in older black and white adultsTangney2004
Frequent intake of tropical fruits that are rich in beta-cryptoxanthin is associated with higher plasma beta-cryptoxanthin concentrations in Costa Rican adolescentsIrwig2002
Development and validation of a brief food frequency questionnaire for dietary lutein and zeaxanthin intake assessment in Italian womenCena2008
Individual carotenoid concentrations in adipose tissue and plasma as biomarkers of dietary intakeEl-Sohemy2002
Application of the method of triads to evaluate the performance of food frequency questionnaires and biomarkers as indicators of long-term dietary intakeKabagambe2001
Validation of three food frequency questionnaires and 24-hour recalls with serum carotenoid levels in a sample of African-American adultsResnicow2000
Plasma carotenoids are biomarkers of long-term high vegetable intake in women with breast cancerMcEligot1999
Carotenoid intakes, assessed by dietary questionnaire, are associated with plasma carotenoid concentrations in an elderly populationTucker1999
Questionnaire assessment of antioxidants and retinol intakes in Mexican womenRomieu1999
Relative validity and reproducibility of a diet history questionnaire in Spain. III. Biochemical markersGonzalez1997
New carotenoid values for foods improve relationship of food frequency questionnaire intake estimates to plasma valuesRitenbaugh1996
Plasma carotenoids as biomarkers of vegetable and fruit intakeCampbell1994
The correlation between the intake of lutein, lycopene and beta-carotene from vegetables and fruits, and blood plasma concentrations in a group of women aged 50-65 years in the UKScott1996
Relationship between dietary intake and plasma concentrations of carotenoids in premenopausal women: application of the USDA-NCI carotenoid food-composition databaseYong1994
The correlation between two dietary assessments of carotenoid intake and plasma carotenoid concentrations: application of a carotenoid food-composition databaseForman1993
Validation of a food frequency questionnaire to assess the consumption of carotenoids, fruits and vegetables among adolescents: the method of triadsSlater2010
Validity and systematic error in measuring carotenoid consumption with dietary self-report instrumentsNatarajan2006
Intraindividual variability in serum micronutrients: effects on reliability of estimated parametersShvetsov2009
Intraindividual variability of plasma antioxidants, markers of oxidative stress, C-reactive protein, cotinine, and other biomarkersBlock2006
Reliability of plasma carotenoid biomarkers and its relation to study powerAl-Delaimy2008
Reproducibility of plasma, red blood cell, and urine biomarkers among premenopausal and postmenopausal women from the Nurses' Health StudiesKotsopoulos2010
Association of selenium, tocopherols, carotenoids, retinol, and 15-isoprostane F(2t) in serum or urine with prostate cancer risk: the multiethnic cohortGill2009
Plasma carotenoids, retinol, and tocopherols and postmenopausal breast cancer risk in the Multiethnic Cohort Study: a nested case-control studyEpplein2009
Association of plasma micronutrient levels and urinary isoprostane with risk of lung cancer: the multiethnic cohort studyEpplein2009
Plasma carotenoids, tocopherols, retinol and breast cancer risk: results from the Shanghai Women Health Study (SWHS)Dorjgochoo2009
Plasma levels of carotenoids, retinol and tocopherol and the risk of gastric cancer in Japan: a nested case-control studyPersson2008
Serum carotenoids, retinol, and tocopherols, and colorectal cancer risk in a Japanese cohort: effect modification by sex for carotenoidsWakai2005
Plasma carotenoids, retinol, and tocopherols and risk of breast cancerTamimi2005
Prediagnostic levels of serum micronutrients in relation to risk of gastric cancer in Shanghai, ChinaYuan2004
Relationships of serum carotenoids, retinol, alpha-tocopherol, and selenium with breast cancer risk: results from a prospective study in Columbia, Missouri (United States)Dorgan1998
Repeated measurements of serum carotenoid, retinol and tocopherol levels in relation to colorectal cancer risk in the Women's Health InitiativeKabat2012
Serum antioxidants and skin cancer risk: an 8-year community-based follow-up studyvan der Pols2009
Longitudinal study of serum carotenoid, retinol, and tocopherol concentrations in relation to breast cancer risk among postmenopausal womenKabat2009
Prospective study of serum retinol, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin and esophageal and gastric cancers in ChinaAbnet2003
Plasma carotenoids and breast cancer risk in the Cancer Prevention Study II Nutrition CohortWang2015
Premenopausal plasma carotenoids, fluorescent oxidation products, and subsequent breast cancer risk in the nurses' health studiesSisti2015
Plasma carotenoids and risk of breast cancer over 20 y of follow-upEliassen2015
Circulating carotenoids, mammographic density, and subsequent risk of breast cancerTamimi2009
Dietary and plasma lycopene and the risk of breast cancerSesso2005
Plasma and dietary carotenoids, and the risk of prostate cancer: a nested case-control studyWu2004
The risk of developing lung cancer associated with antioxidants in the blood: ascorbic acid, carotenoids, alpha-tocopherol, selenium, and total peroxyl radical absorbing capacityComstock1997
Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studiesEliassen2012
Prediagnostic levels of serum beta-cryptoxanthin and retinol predict smoking-related lung cancer risk in Shanghai, ChinaYuan2001
Serum carotenoids and other antioxidative substances associated with urothelial cancer risk in a nested case-control study in Japanese menOzasa2005
Serum vitamins and the subsequent risk of bladder cancerNomura2003

Biomarker data

Measurements of Lutein/Zeaxanthin in biospecimens

Concentration values

IDParent IDDepthSubject groupPopulationCountryCohortBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianConverted unitAdjustment typeAdjusted onRegressed onExpressed asPublication

Reproducibility values

IDExcretion IDSubject groupPopulationCountryCohortBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication

Associations of Lutein/Zeaxanthin with exposures

Correlation values

IDIntake IDExcretion IDSubject groupPopulationCountryCohortIntake Time definitionIntake Assessment methodIntakeIntake detailSupplement intakes included?Intake Arithmetic meanIntake Geometric meanIntake MedianIntake UnitIntake Adjusted onBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailBiomarker Arithmetic meanBiomarker Geometric meanBiomarker MedianBiomarker UnitBiomarker Adjusted onCorrelation sizeCorrelation typeCorrelation valueCorrelation 95% CI lowerCorrelation 95% CI upperCorrelation p-valueSignificant?Measurement adjustmentDeattenuated?CovariatesPublication

Metabolomic associations

IDIntake IDExcretion IDSubject groupPopulationCountryCohortNo. of subjectsIntake Assessment methodIntakeIntervention doseBiospecimenAnalytical methodBiomarkerStructural identificationFeature selectionArea under curveSensitivitySpecificityPLS-DA VIPBeta coefficientBeta coefficient p-valueANOVA p-valuePublication

Associations of Lutein/Zeaxanthin with cancer risk

Cancer associations

IDExcretion IDSubject groupPopulationCountryCohortNo. of subjectsNo. of casesNo. of controlsBiospecimenAnalytical methodBiomarkerBiomarker detailCancerStudy designPublication

Exposure data

Measurements of Lutein/Zeaxanthin exposures in populations

Intake values

IDParent IDDepthSubject groupPopulationCountryCohortIntake Time definitionIntake assessment toolIntake food coverageIntake time coverageIntake Assessment methodIntakeIntake detailFood descriptionSupplement intakes included?Measurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianConverted unitAdjustment typeAdjusted onRegressed onExpressed asPublication

Associations of Lutein/Zeaxanthin exposures with biomarkers

Correlation values

IDIntake IDExcretion IDSubject groupPopulationCountryCohortIntake Time definitionIntake Assessment methodIntakeIntake detailSupplement intakes included?Intake Arithmetic meanIntake Geometric meanIntake MedianIntake UnitIntake Adjusted onBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailBiomarker Arithmetic meanBiomarker Geometric meanBiomarker MedianBiomarker UnitBiomarker Adjusted onCorrelation sizeCorrelation typeCorrelation valueCorrelation 95% CI lowerCorrelation 95% CI upperCorrelation p-valueSignificant?Measurement adjustmentDeattenuated?CovariatesPublication