1,2,3,6,7,8-HxCDF (Compound)

Go to Compound classification
ID927
Name1,2,3,6,7,8-HxCDF
Synonyms1,2,3,6,7,8-Hexachlorodibenzo-furan
StructureThumb
Description
ClassificationCompounds > Pollution > Air and water pollutants > Dioxins (PCDD/F) > Polychlorodibenzo-furans (PCDF)
CAS number57117-44-9
PubChem ID42140
ChEBI ID81511
FooDB ID
HMDB ID

Chemical data

MolDBi data

IUPAC Name3,4,5,10,11,12-hexachloro-8-oxatricyclo[7.4.0.0²,⁷]trideca-1(13),2,4,6,9,11-hexaene
Traditional IUPAC Name3,4,5,10,11,12-hexachloro-8-oxatricyclo[7.4.0.0²,⁷]trideca-1(13),2,4,6,9,11-hexaene
FormulaC12H2Cl6O
InChIInChI=1S/C12H2Cl6O/c13-4-1-3-7-6(2-5(14)8(15)10(7)17)19-12(3)11(18)9(4)16/h1-2H
InChI KeyJEYJJJXOFWNEHN-UHFFFAOYSA-N
Molecular weight374.862
Exact mass371.823680928
SMILESClC1=C(Cl)C(Cl)=C2C(OC3=C(Cl)C(Cl)=C(Cl)C=C23)=C1

ClassyFire Taxonomy

Description belongs to the class of organic compounds known as polychlorinated dibenzofurans. These are organic compounds containing two or more chlorine atoms attached to a dibenzofuran moiety.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzofurans
Sub ClassDibenzofurans
Direct ParentPolychlorinated dibenzofurans
Alternative Parents

Publications with 1,2,3,6,7,8-HxCDF

TitleFirst authorYear
PCDD, PCDF, and PCB exposure in current and former firefighters from Eastern SiberiaChernyak2012
Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls in blood and breast milk collected from pregnant women in Sapporo City, JapanTodaka2011
Longitudinal increases in PCDD/F and dl-PCB concentrations in human milk in northern ChinaSun2011
Distribution of PCDD/Fs, PCBs, PBDEs and organochlorine residues in children’s blood from Zhejiang, ChinaShen2010
Levels of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and trace metals in the blood of nonoccupationally exposed residents living in the vicinity of a municipal solid waste incinerator and electric arc furnaceChen2010
Relationship between the concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls in maternal blood and those in breast milkTodaka2010
Serum levels of polychlorinated dibenzodioxins and dibenzofurans and PCBs in the general population living near an urban waste treatment plant in Biscay, Basque CountryZubero2009
Evaluation of background persistent organic pollutant levels in human from Taiwan: Polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenylsHsu2009
PCDD/F and PCB in human serum of differently exposed population groups of an Italian cityTurrio-Baldassarri2008
PCDD/F levels in plasma of a belgian population before and after the 1999 belgian PCB/DIOXIN incidentDebacker2007
PCDD/F and dioxin-like PCB in human blood and milk from German mothersWittsiepe2007
Serum concentrations of chlorinated dibenzo-p-dioxins and dibenzofurans among former Michigan trichlorophenol and pentachlorophenol workersCollins2007
Evaluation of PCDD/Fs patterns emitted from incinerator via direct ambient sampling and indirect serum levels assessment of TaiwaneseLee2005
Profile of PCDD/F levels in serum of general Taiwanese between different gender, age and smoking statusChen2005
Decrease of PCDD/F levels in human blood--trend analysis for the German population, 1991-1996Wittsiepe2000
Serum PCDD/F concentration distribution in residents living in the vicinity of an incinerator and its association with predicted ambient dioxin exposureChen2004
Polychlorinated dibenzo-p-dioxin and dibenzofuran concentrations in serum samples of workers at intermittently burning municipal waste incinerators in JapanKumagai2002
PCDD/F concentrations in milk of nonoccupationally exposed women living in southern Catalonia, SpainSchuhmacher1999
Partitioning of dioxins, dibenzofurans, and coplanar PCBS in blood, milk, adipose tissue, placenta and cord blood from five American womenSchecter1998
Chlorinated dibenzodioxins and dibenzofurans (PCDD/F) in blood and human milk of non occupationally exposed persons living in the vicinity of a municipal waste incineratorDeml1996
Levels of PCDD/PCDF in blood fat as indices of the PCDD/PCDF body burden in humansEwers1996
Polychlorinated dibenzo-p-dioxin and dibenzofuran concentrations in the serum samples of workers at continuously burning municipal waste incinerators in JapanKumagai2000
Estimation of age- and sex-specific background human serum concentrations of PCDDs, PCDFs, and PCBs in the UMDES and NHANES populationsChen2013
Correlations of fish intake and plasma docosahexaenoic acid levels with each congener of PCDDs/PCDFs/dioxin-like PCBs in blood from the Japanese populationKitayama2011
Determination of dioxins and polychlorinated biphenyls in breast milk, maternal blood and cord blood from residents of Tohoku, JapanNakamura2008
Effects of prenatal exposure to polychlorinated biphenyls and dioxins on mental and motor development in Japanese children at 6 months of ageNakajima2006
Fish intake, plasma omega-3 polyunsaturated fatty acids, and polychlorinated dibenzo-p-dioxins/polychlorinated dibenzo-furans and co-planar polychlorinated biphenyls in the blood of the Japanese populationArisawa2003

Biomarker data

Measurements of 1,2,3,6,7,8-HxCDF in biospecimens

Concentration values

IDParent IDDepthSubject groupPopulationCountryCohortBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianConverted unitAdjustment typeAdjusted onRegressed onExpressed asPublication

Reproducibility values

IDExcretion IDSubject groupPopulationCountryCohortBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication

Associations of 1,2,3,6,7,8-HxCDF with exposures

Correlation values

IDIntake IDExcretion IDSubject groupPopulationCountryCohortIntake Time definitionIntake Assessment methodIntakeIntake detailSupplement intakes included?Intake Arithmetic meanIntake Geometric meanIntake MedianIntake UnitIntake Adjusted onBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailBiomarker Arithmetic meanBiomarker Geometric meanBiomarker MedianBiomarker UnitBiomarker Adjusted onCorrelation sizeCorrelation typeCorrelation valueCorrelation 95% CI lowerCorrelation 95% CI upperCorrelation p-valueSignificant?Measurement adjustmentDeattenuated?CovariatesPublication

Metabolomic associations

IDIntake IDExcretion IDSubject groupPopulationCountryCohortNo. of subjectsIntake Assessment methodIntakeIntervention doseBiospecimenAnalytical methodBiomarkerStructural identificationFeature selectionArea under curveSensitivitySpecificityPLS-DA VIPBeta coefficientBeta coefficient p-valueANOVA p-valuePublication

Associations of 1,2,3,6,7,8-HxCDF with cancer risk

Cancer associations

IDExcretion IDSubject groupPopulationCountryCohortNo. of subjectsNo. of casesNo. of controlsBiospecimenAnalytical methodBiomarkerBiomarker detailCancerStudy designPublication

Exposure data

Measurements of 1,2,3,6,7,8-HxCDF exposures in populations

Intake values

IDParent IDDepthSubject groupPopulationCountryCohortIntake Time definitionIntake assessment toolIntake food coverageIntake time coverageIntake Assessment methodIntakeIntake detailFood descriptionSupplement intakes included?Measurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianConverted unitAdjustment typeAdjusted onRegressed onExpressed asPublication

Associations of 1,2,3,6,7,8-HxCDF exposures with biomarkers

Correlation values

IDIntake IDExcretion IDSubject groupPopulationCountryCohortIntake Time definitionIntake Assessment methodIntakeIntake detailSupplement intakes included?Intake Arithmetic meanIntake Geometric meanIntake MedianIntake UnitIntake Adjusted onBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailBiomarker Arithmetic meanBiomarker Geometric meanBiomarker MedianBiomarker UnitBiomarker Adjusted onCorrelation sizeCorrelation typeCorrelation valueCorrelation 95% CI lowerCorrelation 95% CI upperCorrelation p-valueSignificant?Measurement adjustmentDeattenuated?CovariatesPublication