LC-MS/MS after enzymatic hydrolysis (Analytical method)

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ID	30
Name	LC-MS/MS after enzymatic hydrolysis
Classification	Analytical methods > Chromatography > Liquid chromatography (LC)

Publications with LC-MS/MS after enzymatic hydrolysis

Title	First author	Year
Relation between plasma enterodiol and enterolactone and dietary intake of lignans in a Dutch Endoscopy-Based Population	Milder	2007
Reliability and validity of an assessment of usual phytoestrogen consumption (United States)	Horn-Ross	2006
Urinary isoflavones and their metabolites validate the dietary isoflavone intakes in US adults	Chun	2009
Relative validity of fruit and vegetable intake estimated from an FFQ, using carotenoid and flavonoid biomarkers and the method of triads	Carlsen	2011
Correlations of urinary phytoestrogen excretion with lifestyle factors and dietary intakes among middle-aged and elderly Chinese women	Wu	2012
Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods	Mennen	2006
Concentrations and profiles of urinary polycyclic aromatic hydrocarbon metabolites (OH-PAHs) in several Asian countries	Guo	2013
Exposure and kinetics of polycyclic aromatic hydrocarbons (PAHs) in cigarette smokers	St Helen	2012
Reproductive hormones in relation to polycyclic aromatic hydrocarbon (PAH) metabolites among non-occupational exposure of males	Han	2010
Relation between urinary metabolites of polycyclic aromatic hydrocarbons and human semen quality	Xia	2009
Reproducibility of plasma, red blood cell, and urine biomarkers among premenopausal and postmenopausal women from the Nurses' Health Studies	Kotsopoulos	2010
Reproducibility of urinary phthalate metabolites in first morning urine samples	Hoppin	2002
Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States	Teitelbaum	2008
Temporal variability in urinary excretion of bisphenol A and seven other phenols in spot, morning, and 24-h urine samples	Lassen	2013
Temporal variability in urinary phthalate metabolite excretion based on spot, morning, and 24-h urine samples: considerations for epidemiological studies	Frederiksen	2013
Urinary 3,5,6-trichloro-2-pyridinol (TCPY) in pregnant women from Mexico City: Distribution, temporal variability, and relationship withchild attention and hyperactivity	Fortenberry	2014
Variability of urinary phthalate metabolite and bisphenol A concentrations before and during pregnancy	Braun	2012
Variability over 1 week in the urinary concentrations of metabolites of diethyl phthalate and di(2-ethylhexyl) phthalate among eight adults: an observational study	Preau	2010
Phthalate metabolites in urine samples from Danish children and correlations with phthalates in dust samples from their homes and daycare centers	Langer	2013
GerES IV: phthalate metabolites and bisphenol A in urine of German children	Becker	2009
DEHP metabolites in urine of children and DEHP in house dust	Becker	2004
Internal exposure of nursery-school children and their parents and teachers to di(2-ethylhexyl)phthalate (DEHP)	Koch	2004
Oxidative metabolites of diisononyl phthalate as biomarkers for human exposure assessment	Silva	2006
Mono(2-ethyl-5-hydroxyhexyl) phthalate and mono-(2-ethyl-5-oxohexyl) phthalate as biomarkers for human exposure assessment to di-(2-ethylhexyl) phthalate	Kato	2004
Exposure to phthalates in 5-6 years old primary school starters in Germany--a human biomonitoring study and a cumulative risk assessment	Koch	2011
Levels of seven urinary phthalate metabolites in a human reference population	Blount	2000
Circulating levels of bisphenol A (BPA) and phthalates in an elderly population in Sweden, based on the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS)	Olsen	2012
Urinary excretion of phthalate metabolites, phenols and parabens in rural and urban Danish mother–child pairs	Frederiksen	2013
Urinary metabolite concentrations of phthalate metabolites in Central Italy healthy volunteers determined by a validated HPLC/MS/MS analytical method	Tranfo	2013
Levels of phthalate metabolites in urine among mother-child-pairs - results from the Duisburg birth cohort study, Germany	Kasper-Sonnenberg	2012
Exposure assessment of phthalates in French pregnant women: results of the ELFE pilot study	Zeman	2013
Phthalate diesters and their metabolites in human breast milk, blood or serum, and urine as biomarkers of exposure in vulnerable populations	Hogberg	2008
Urinary and air phthalate concentrations and self-reported use of personal care products among minority pregnant women in New York city	Just	2010
Levels of metabolites of organophosphate pesticides, phthalates, and bisphenol A in pooled urine specimens from pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa)	Ye	2009
Exposure to phthalates among premenstrual girls from rural and urban Gharbiah, Egypt: a pilot exposure assessment study	Colacino	2011
Characterization of phthalate exposure among pregnant women assessed by repeat air and urine samples	Adibi	2008
Occurrence and daily variation of phthalate metabolites in the urine of an adult population	Fromme	2007
Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000	Silva	2004
Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls	Wolff	2007
Internal phthalate exposure over the last two decades--a retrospective human biomonitoring study	Wittassek	2007
Exposure of nursery school children and their parents and teachers to di-n-butylphthalate and butylbenzylphthalate	Koch	2005
Phthalate metabolites in urine from China, and implications for human exposures	Guo	2011
Occurrence of phthalate metabolites in human urine from several Asian countries	Guo	2011
Internal exposure of the general population to DEHP and other phthalates--determination of secondary and primary phthalate monoester metabolites in urine	Koch	2003
Phthalate exposure in pregnant women and their children in central Taiwan	Lin	2011
Biomonitoring of phthalate metabolites in the Canadian population through the Canadian Health Measures Survey (2007–2009)	Saravanabhavan	2013
Phthalate and di-(2-ethylhexyl) adipate (DEHA) intake by German infants based on the results of a duplicate diet study and biomonitoring data (INES 2)	Fromme	2013
Phthalate exposure among pregnant women in Jerusalem, Israel: results of a pilot study	Berman	2009
Urinary concentrations of phthalates and phenols in a population of Spanish pregnant women and children	Casas	2011
Urinary excretion of phthalate metabolites in 129 healthy Danish children and adolescents: estimation of daily phthalate intake	Frederiksen	2011
An estimate of phthalate exposure among pregnant women living in Trujillo, Peru	Irvin	2010
Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and phthalates among pregnant women in Rotterdam, the Netherlands: The Generation R study	Ye	2008
Determinants of urinary bisphenol A concentrations in Mexican/Mexican–American pregnant women	Quiros-Alcala	2013
Phthalates and their metabolites in breast milk--results from the Bavarian Monitoring of Breast Milk (BAMBI)	Fromme	2011
Quantitative identification of unknown exposure pathways of phthalates based on measuring their metabolites in human urine	Itoh	2007
Variability of phthalate monoester levels in daily first-morning urine from adult women: a pilot study	Marcus	2010

Biomarker data

Measurements of biomarkers by LC-MS/MS after enzymatic hydrolysis

Concentration values

ID	Parent ID	Depth	Subject group	Population	Country	Cohort	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Measurement size	Detected (nb)	Detected (%)	Detected only?	Arithmethic mean	Arithmethic SD	Geometric mean	Geometric SD	Min	Min (detected)	Percentile_05	Percentile_10	Percentile_25	Median	Percentile_75	Percentile_90	Percentile_95	Max	Interquartile range	Mean 95% CI lower	Mean 95% CI upper	GMean 95% CI lower	GMean 95% CI upper	Unit	Converted arithmetic mean	Converted geometric mean	Converted median	Converted unit	Adjustment type	Adjusted on	Regressed on	Expressed as	Publication

Reproducibility values

ID	Excretion ID	Subject group	Population	Country	Cohort	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Arithmetic mean	Geometric mean	Median	Unit	Adjusted on	Reproducibility size	ICC	ICC 95% CI lower	ICC 95% CI upper	CV% WS	CV% BS	VAR WS	VAR BS	Publication

Associations of biomarkers measured by LC-MS/MS after enzymatic hydrolysis and exposures

Correlation values

ID	Intake ID	Excretion ID	Subject group	Population	Country	Cohort	Intake Time definition	Intake Assessment method	Intake	Intake detail	Supplement intakes included?	Intake Arithmetic mean	Intake Geometric mean	Intake Median	Intake Unit	Intake Adjusted on	Biomarker Time definition	Biospecimen	Analytical method	Biomarker	Biomarker detail	Biomarker Arithmetic mean	Biomarker Geometric mean	Biomarker Median	Biomarker Unit	Biomarker Adjusted on	Correlation size	Correlation type	Correlation value	Correlation 95% CI lower	Correlation 95% CI upper	Correlation p-value	Significant?	Measurement adjustment	Deattenuated?	Covariates	Publication

Metabolomic associations

ID	Intake ID	Excretion ID	Subject group	Population	Country	Cohort	No. of subjects	Intake Assessment method	Intake	Intervention dose	Biospecimen	Analytical method	Biomarker	Structural identification	Feature selection	Area under curve	Sensitivity	Specificity	PLS-DA VIP	Beta coefficient	Beta coefficient p-value	ANOVA p-value	Publication

Associations of biomarkers measured by LC-MS/MS after enzymatic hydrolysis and cancer risk

Cancer associations

ID	Excretion ID	Subject group	Population	Country	Cohort	No. of subjects	No. of cases	No. of controls	Biospecimen	Analytical method	Biomarker	Biomarker detail	Cancer	Study design	Publication