Kotsopoulos 2010

ID457
TitleReproducibility of plasma, red blood cell, and urine biomarkers among premenopausal and postmenopausal women from the Nurses' Health Studies
AuthorsKotsopoulos, J.; Tworoger, S. S.; Campos, H.; Chung, F. L.; Clevenger, C. V.; Franke, A. A.; Mantzoros, C. S.; Ricchiuti, V.; Willett, W. C.; Hankinson, S. E.; Eliassen, A. H.
Year2010
JournalCancer Epidemiol Biomarkers Prev
Volume19
Issue4
Pages938-946
PubMed ID20332276
DOI10.1158/1055-9965.EPI-09-1318

Subjects

IDParent IDDepthSubject groupPopulationCountryCountry codeEthnicityCohortHealth conditionSmoker proportionSupplement users excluded?GenderFemale proportionSizeAge meanAge SDAge minAge maxAge medianHeight meanHeight SDHeight minHeight maxHeight medianWeight meanWeight SDWeight minWeight maxWeight medianBMI meanBMI SDBMI minBMI maxBMI median
15570AllNursesUnited StatesUSNHS (Nurses' Health Study)UnspecifiedFemale100.0110

Biomarker concentration values

IDParent IDDepthSubject groupPopulationCountryCountry codeCohortTime definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianAdjustment typeAdjusted onRegressed onExpressed as
18628186331AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedHPLCLutein/Zeaxanthin40102.0228.0428.0ug/L0.2 mg/LCrude
18629186331AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedHPLCbeta-Cryptoxanthin4042.493.3231.5ug/L0.1 mg/LCrude
18630186331AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedHPLCLycopene40195.0414.0691.0ug/L0.4 mg/LCrude
18631186331AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedHPLCalpha-Carotene4028.569.6233.0ug/L0.1 mg/LCrude
18632186331AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedHPLCbeta-Carotene4086.9288.0711.0ug/L0.3 mg/LCrude
186330AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedHPLCCarotenoidsLutein/Zeaxanthin
Lycopene
alpha-Carotene
beta-Carotene
beta-Cryptoxanthin
40511.01098.02077.0ug/L1.1 mg/LCrude
186340AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedHPLCRetinol40402.0571.0798.0ug/L0.6 mg/LCrude
186350AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedHPLCgamma-Tocopherol40398.02295.04328.0ug/L2.3 mg/LCrude
186360AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedHPLCalpha-Tocopherol407336.011535.022844.0ug/L11.5 mg/LCrude
186430AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedLC-MS/MS after enzymatic hydrolysisDaidzein400.254.0576.2nmol/L4.1 nmol/LCrude
186440AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedLC-MS/MS after enzymatic hydrolysisGenistein400.42.750.5nmol/L2.7 nmol/LCrude
186450AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedLC-MS/MS after enzymatic hydrolysisEquol400.00.61.4nmol/L0.6 nmol/LCrude
186460AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedLC-MS/MS after enzymatic hydrolysisEnterolactone403.14.147.0nmol/L4.1 nmol/LCrude
18638186371AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsRed blood cell, unspecifiedGC-FIDFatty acids, saturated (SFA)4030.535.638.3percentRoot35.6 percentRootCrude
18639186371AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsRed blood cell, unspecifiedGC-FIDFatty acids, monounsaturated (MUFA)4013.215.416.6percentRoot15.4 percentRootCrude
18640186371AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsRed blood cell, unspecifiedGC-FIDFatty acids, n3-polyunsaturated (n3-PUFA)403.74.96.6percentRoot4.9 percentRootCrude
18641186371AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsRed blood cell, unspecifiedGC-FIDFatty acids, n6-polyunsaturated (n6-PUFA)4024.928.130.0percentRoot28.1 percentRootCrude
18642186371AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsRed blood cell, unspecifiedGC-FIDFatty acids, trans400.760.991.64percentRoot1.0 percentRootCrude
186470AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDaidzein450.040.232.34nmol/mg0.2 umol/gDensityCreatinine
186520AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-MS/MS after enzymatic hydrolysisGenistein450.010.111.12nmol/mg0.1 umol/gDensityCreatinine
186530AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-MS/MS after enzymatic hydrolysisEquol450.010.040.29nmol/mg0.0 umol/gDensityCreatinine
186540AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-MS/MS after enzymatic hydrolysisEnterolactone450.061.447.07nmol/mg1.4 umol/gDensityCreatinine
205150AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotHPLCIsothiocyanates400.00.020.12umol/mg20.0 umol/gDensityCreatinine
186560AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 1 year; 2 yearsPlasma, unspecifiedRadioimmunoassay25-Hydroxycholecalciferol7116.633.351.8ng/mL0.0 mg/LCrude
186580AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 1 year; 2 yearsPlasma, unspecifiedRadioimmunoassay1,25-Dihydroxycholecalciferol7121.035.761.0pg/mL0.0 mg/LCrude

Intake values

No data available

Correlation values

No data available

Reproducibility values

IDMst. IDSubject groupPopulationCountryCountry codeCohortTime definitionBiological specimenExperimental methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BS
28518628AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedHPLCLutein/Zeaxanthin228.0ug/L400.80.660.8919.438.9
28618629AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedHPLCbeta-Cryptoxanthin93.3ug/L400.880.790.9317.948.5
28718630AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedHPLCLycopene414.0ug/L400.740.580.8621.737.3
28818631AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedHPLCalpha-Carotene69.6ug/L400.730.570.8534.958.7
28918632AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedHPLCbeta-Carotene288.0ug/L400.730.560.8532.954.7
29018633AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedHPLCCarotenoidsLutein/Zeaxanthin
Lycopene
alpha-Carotene
beta-Carotene
beta-Cryptoxanthin
1098.0ug/L400.810.680.8918.538.6
29118634AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedHPLCRetinol571.0ug/L400.790.650.889.618.9
29218635AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedHPLCgamma-Tocopherol2295.0ug/L400.880.780.9324.666.0
29318636AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedHPLCalpha-Tocopherol11535.0ug/L400.830.720.9113.229.8
29418638AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsRed blood cell, unspecifiedGC-FIDFatty acids, saturated (SFA)35.6percentRoot400.380.170.655.34.2
29518639AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsRed blood cell, unspecifiedGC-FIDFatty acids, monounsaturated (MUFA)15.4percentRoot400.520.30.735.05.3
29618640AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsRed blood cell, unspecifiedGC-FIDFatty acids, n3-polyunsaturated (n3-PUFA)4.9percentRoot400.680.490.8210.515.3
29718641AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsRed blood cell, unspecifiedGC-FIDFatty acids, n6-polyunsaturated (n6-PUFA)28.1percentRoot400.390.170.665.04.1
29818642AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsRed blood cell, unspecifiedGC-FIDFatty acids, trans0.99percentRoot400.720.550.8412.119.7
29918643AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedLC-MS/MS after enzymatic hydrolysisDaidzein4.05nmol/L400.0100.00.0
30018644AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedLC-MS/MS after enzymatic hydrolysisGenistein2.7nmol/L400.030.01.0100.031.1
30118645AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedLC-MS/MS after enzymatic hydrolysisEquol0.6nmol/L400.053.50.0
30218646AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsPlasma, unspecifiedLC-MS/MS after enzymatic hydrolysisEnterolactone4.1nmol/L400.440.220.6861.254.9
30318647AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDaidzein0.23nmol/mgCreatinine450.0100.00.0
30418652AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-MS/MS after enzymatic hydrolysisGenistein0.11nmol/mgCreatinine450.020.01.0100.00.0
30518653AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-MS/MS after enzymatic hydrolysisEquol0.04nmol/mgCreatinine450.090.00.778.93.0
30618654AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotLC-MS/MS after enzymatic hydrolysisEnterolactone1.44nmol/mgCreatinine450.520.310.7295.3100.0
30718656AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 1 year; 2 yearsPlasma, unspecifiedRadioimmunoassay25-Hydroxycholecalciferol33.3ng/mL710.720.620.818.429.6
30818658AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 1 year; 2 yearsPlasma, unspecifiedRadioimmunoassay1,25-Dihydroxycholecalciferol35.7pg/mL710.560.430.6820.723.5
89720515AllNursesUnited StatesUSNHS (Nurses' Health Study)baseline; 2 yearsUrine, first morning spotHPLCIsothiocyanates0.02umol/mgCreatinine400.180.030.66.73.2