Frederiksen 2013

ID464
TitleTemporal variability in urinary phthalate metabolite excretion based on spot, morning, and 24-h urine samples: considerations for epidemiological studies
AuthorsFrederiksen, H.; Kranich, S. K.; Jorgensen, N.; Taboureau, O.; Petersen, J. H.; Andersson, A. M.
Year2013
JournalEnviron Sci Technol
Volume47
Issue2
Pages958-967
PubMed ID23234290
DOI10.1021/es303640b

Subjects

IDParent IDDepthSubject groupPopulationCountryCountry codeEthnicityCohortHealth conditionSmoker proportionSupplement users excluded?GenderFemale proportionSizeAge meanAge SDAge minAge maxAge medianHeight meanHeight SDHeight minHeight maxHeight medianWeight meanWeight SDWeight minWeight maxWeight medianBMI meanBMI SDBMI minBMI maxBMI median
15720AllParticipants in a study of reproductive healthDenmarkDKUnspecifiedMale0.03319.318.322.3182.0171.0197.076.653.993.223.216.531.9

Biomarker concentration values

IDParent IDDepthSubject groupPopulationCountryCountry codeCohortTime definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianAdjustment typeAdjusted onRegressed onExpressed as
187300AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMonoethyl phthalate (MEP)33100.04.9913.320.153.1100.0939.019953.0ng/mL0.1 mg/LCrude
187310AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDBP metabolitesMono-isobutyl phthalate (MiBP)
Mono-n-butyl phthalate (MnBP)
33100.020.844.271.1116.0189.0318.0912.0ng/mL0.1 mg/LCrude
187320AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMonobenzyl phthalate (MBzP)3398.00.03.2714.833.669.1178.0549.0ng/mL0.0 mg/LCrude
18733187421AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)33100.00.51.323.525.668.4622.4196.0ng/mL0.0 mg/LCrude
18734187421AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)33100.03.4910.321.432.645.8107.0867.0ng/mL0.0 mg/LCrude
18735187421AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)33100.02.427.5713.421.931.467.3848.0ng/mL0.0 mg/LCrude
187360AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)33100.03.186.7913.318.828.160.8348.0ng/mL0.0 mg/LCrude
187370AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-n-octyl phthalate (MnOP)3310.00.00.00.00.00.00.070.67ng/mL0.0 mg/LCrude
18738187431AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-isononyl phthalate (MiNP)3346.00.00.00.00.02.535.7414.7ng/mL0.0 mg/LCrude
18739187431AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)3397.00.01.24.518.4212.938.3115.0ng/mL0.0 mg/LCrude
18740187431AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-oxo-isononyl phthalate (oxo-MiNP)33100.00.260.952.744.236.8317.4181.0ng/mL0.0 mg/LCrude
18741187431AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(carboxy-isooctyl) phthalate (MCOP)33100.01.283.526.9411.018.538.3166.0ng/mL0.0 mg/LCrude
187420AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
3314.538.370.6108.0146.0311.03001.0ng/mL0.1 mg/LCrude
187430AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDiNP metabolitesMono(carboxy-isooctyl) phthalate (MCOP)
Mono-hydroxy-isononyl phthalate (OH-MiNP)
Mono-isononyl phthalate (MiNP)
Mono-oxo-isononyl phthalate (oxo-MiNP)
332.48.3921.937.452.5138.0503.0ng/mL0.0 mg/LCrude
187460AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMonoethyl phthalate (MEP)33100.02.977.5729.770.4354.02030.03321.0ng/mL0.1 mg/LCrude
187470AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisDBP metabolitesMono-isobutyl phthalate (MiBP)
Mono-n-butyl phthalate (MnBP)
33100.06.2929.274.8106.0150.0283.0366.0ng/mL0.1 mg/LCrude
187480AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMonobenzyl phthalate (MBzP)3397.00.02.328.8825.058.9149.0688.0ng/mL0.0 mg/LCrude
18749187581AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)33100.00.351.173.025.299.0517.451.2ng/mL0.0 mg/LCrude
18750187581AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)33100.00.923.3312.723.731.792.8178.0ng/mL0.0 mg/LCrude
18751187581AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)33100.00.432.5610.116.722.161.0101.0ng/mL0.0 mg/LCrude
187520AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)33100.00.773.1310.916.222.658.4116.0ng/mL0.0 mg/LCrude
187530AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-n-octyl phthalate (MnOP)339.00.00.00.00.00.00.050.09ng/mL0.0 mg/LCrude
18754187591AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isononyl phthalate (MiNP)3343.00.00.00.00.01.746.427.4ng/mL0.0 mg/LCrude
18755187591AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)3398.00.00.532.634.499.3521.861.0ng/mL0.0 mg/LCrude
18756187591AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-oxo-isononyl phthalate (oxo-MiNP)3398.00.00.271.482.554.7614.947.7ng/mL0.0 mg/LCrude
18757187591AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(carboxy-isooctyl) phthalate (MCOP)33100.00.761.515.378.8414.849.8101.0ng/mL0.0 mg/LCrude
187580AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
333.2614.154.0883.211.0290.0580.0ng/mL0.1 mg/LCrude
187590AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisDiNP metabolitesMono(carboxy-isooctyl) phthalate (MCOP)
Mono-hydroxy-isononyl phthalate (OH-MiNP)
Mono-isononyl phthalate (MiNP)
Mono-oxo-isononyl phthalate (oxo-MiNP)
331.743.5214.8922.540.5113.0289.0ng/mL0.0 mg/LCrude
187600AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMonoethyl phthalate (MEP)33100.08.4412.322.238.6104.01174.02635.0ng/mL0.0 mg/LCrude
187610AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisDBP metabolitesMono-isobutyl phthalate (MiBP)
Mono-n-butyl phthalate (MnBP)
33100.018.428.151.874.8123.0301.01640.0ng/mL0.1 mg/LCrude
187620AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMonobenzyl phthalate (MBzP)3398.00.02.9611.121.243.5146.0658.0ng/mL0.0 mg/LCrude
18763187721AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)33100.00.91.563.485.498.3116.1232.0ng/mL0.0 mg/LCrude
18764187721AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)33100.04.667.5215.725.336.671.7688.0ng/mL0.0 mg/LCrude
18765187721AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)33100.03.575.1910.916.922.544.4634.0ng/mL0.0 mg/LCrude
187660AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)33100.04.355.219.9514.722.740.9385.0ng/mL0.0 mg/LCrude
187670AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMono-n-octyl phthalate (MnOP)333.00.00.00.00.00.00.00.88ng/mL0.0 mg/LCrude
18768187731AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMono-isononyl phthalate (MiNP)3347.00.00.00.00.02.388.2632.6ng/mL0.0 mg/LCrude
18769187731AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)33100.00.771.493.195.689.3531.1204.0ng/mL0.0 mg/LCrude
18770187731AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMono-oxo-isononyl phthalate (oxo-MiNP)33100.00.430.791.692.974.8918.661.9ng/mL0.0 mg/LCrude
18771187731AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMono(carboxy-isooctyl) phthalate (MCOP)33100.01.362.644.318.414.757.2161.0ng/mL0.0 mg/LCrude
187720AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
3321.427.452.285.6119.1217.02575.0ng/mL0.1 mg/LCrude
187730AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisDiNP metabolitesMono(carboxy-isooctyl) phthalate (MCOP)
Mono-hydroxy-isononyl phthalate (OH-MiNP)
Mono-isononyl phthalate (MiNP)
Mono-oxo-isononyl phthalate (oxo-MiNP)
333.597.7514.624.941.4139.0594.0ng/mL0.0 mg/LCrude

Intake values

No data available

Correlation values

No data available

Reproducibility values

IDMst. IDSubject groupPopulationCountryCountry codeCohortTime definitionBiological specimenExperimental methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BS
38318730AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMonoethyl phthalate (MEP)53.1ng/mL330.330.110.551.0740.524
38418731AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDBP metabolitesMono-isobutyl phthalate (MiBP)
Mono-n-butyl phthalate (MnBP)
116.0ng/mL330.370.150.590.3160.187
38518732AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMonobenzyl phthalate (MBzP)33.6ng/mL330.310.10.541.0650.485
38618733AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)5.66ng/mL330.210.00.450.6080.157
38718734AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)32.6ng/mL330.210.00.450.5320.143
38818742AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
108.0ng/mL330.210.00.450.4720.123
38918743AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDiNP metabolitesMono(carboxy-isooctyl) phthalate (MCOP)
Mono-hydroxy-isononyl phthalate (OH-MiNP)
Mono-isononyl phthalate (MiNP)
Mono-oxo-isononyl phthalate (oxo-MiNP)
37.4ng/mL330.250.040.490.5990.2
39118746AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMonoethyl phthalate (MEP)70.4ng/mL330.650.390.811.011.873
39418747AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisDBP metabolitesMono-isobutyl phthalate (MiBP)
Mono-n-butyl phthalate (MnBP)
106.0ng/mL330.390.050.640.2850.179
39218748AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMonobenzyl phthalate (MBzP)25.0ng/mL330.380.040.651.5120.933
39918749AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)5.29ng/mL330.370.030.630.4580.265
39318750AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)23.7ng/mL330.190.00.50.6650.157
40018758AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
83.2ng/mL330.190.00.50.5710.138
39818759AllParticipants in a study of reproductive healthDenmarkDKbaseline; 4 daysUrine, spotLC-MS/MS after enzymatic hydrolysisDiNP metabolitesMono(carboxy-isooctyl) phthalate (MCOP)
Mono-hydroxy-isononyl phthalate (OH-MiNP)
Mono-isononyl phthalate (MiNP)
Mono-oxo-isononyl phthalate (oxo-MiNP)
22.5ng/mL330.080.00.410.790.066
40118760AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMonoethyl phthalate (MEP)38.6ng/mL330.510.30.70.7810.826
39518761AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisDBP metabolitesMono-isobutyl phthalate (MiBP)
Mono-n-butyl phthalate (MnBP)
74.8ng/mL330.560.360.730.1670.211
40218762AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMonobenzyl phthalate (MBzP)21.2ng/mL330.590.390.750.4240.601
39618763AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)5.49ng/mL330.190.00.430.4770.114
40318764AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)25.3ng/mL330.090.00.330.4090.041
39718772AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
85.6ng/mL330.060.00.30.3990.027
40418773AllParticipants in a study of reproductive healthDenmarkDKbaseline; 40 days; 83 daysUrine, 24-hLC-MS/MS after enzymatic hydrolysisDiNP metabolitesMono(carboxy-isooctyl) phthalate (MCOP)
Mono-hydroxy-isononyl phthalate (OH-MiNP)
Mono-isononyl phthalate (MiNP)
Mono-oxo-isononyl phthalate (oxo-MiNP)
24.9ng/mL330.260.050.50.5770.203