Frederiksen 2013

ID509
TitleUrinary excretion of phthalate metabolites, phenols and parabens in rural and urban Danish mother–child pairs
AuthorsFrederiksen, H.; Nielsen, J. K.; Morck, T. A.; Hansen, P. W.; Jensen, J. F.; Nielsen, O.; Andersson, A. M.; Knudsen, L. E.
Year2013
JournalInt J Hyg Environ Health
Volume216
Issue6
Pages772-783
PubMed ID23528233
DOI10.1016/j.ijheh.2013.02.006

Subjects

IDParent IDDepthSubject groupPopulationCountryCountry codeEthnicityCohortHealth conditionSmoker proportionSupplement users excluded?GenderFemale proportionSizeAge meanAge SDAge minAge maxAge medianHeight meanHeight SDHeight minHeight maxHeight medianWeight meanWeight SDWeight minWeight maxWeight medianBMI meanBMI SDBMI minBMI maxBMI median
16720AllMother-child pairs in rural and urban DenmarkDenmarkDKUnspecifiedFemale + Male290
167316721ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKHealthyUnspecifiedFemale + Male50.01458.56.011.0137.6116.0165.031.018.065.016.211.224.9
167416721MothersMother-child pairs in rural and urban DenmarkDenmarkDKUnspecifiedFemale100.014540.931.052.0169.7154.0190.067.445.0150.023.417.349.5

Biomarker concentration values

IDParent IDDepthSubject groupPopulationCountryCountry codeCohortTime definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianAdjustment typeAdjusted onRegressed onExpressed as
194450ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMonoethyl phthalate (MEP)14528.05.57.913.019.029.093.0233.0ug/g28.0 ug/g19.0 ug/gDensityCreatinine
19446194481ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)14571.014.025.039.058.084.0165.0474.0ug/g71.0 ug/g58.0 ug/gDensityCreatinine
19447194481ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-n-butyl phthalate (MnBP)14537.08.813.022.033.047.072.0125.0ug/g37.0 ug/g33.0 ug/gDensityCreatinine
194480ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDBP metabolitesMono-isobutyl phthalate (MiBP)
Mono-n-butyl phthalate (MnBP)
145108.024.038.064.096.0124.0244.0590.0ug/g108.0 ug/g96.0 ug/gDensityCreatinine
194490ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMonobenzyl phthalate (MBzP)14511.02.04.37.412.036.079.0ug/g11.0 ug/g7.4 ug/gDensityCreatinine
19450194541ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)1454.10.321.32.23.88.3175.0ug/g4.1 ug/g2.2 ug/gDensityCreatinine
19451194541ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)14531.03.711.016.022.035.070.0275.0ug/g31.0 ug/g22.0 ug/gDensityCreatinine
19452194541ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)14515.01.54.97.911.017.033.0204.0ug/g15.0 ug/g11.0 ug/gDensityCreatinine
19453194541ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)14522.03.16.911.016.024.051.0435.0ug/g22.0 ug/g16.0 ug/gDensityCreatinine
194540ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
14595.011.031.047.065.0109.0230.01437.0ug/g95.0 ug/g65.0 ug/gDensityCreatinine
194550ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-n-octyl phthalate (MnOP)14514.00.060.282.3ug/g0.1 ug/gDensityCreatinine
194560ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)14516.01.62.85.87.813.050.0410.0ug/g16.0 ug/g7.8 ug/gDensityCreatinine
19457194611ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-isononyl phthalate (MiNP)14517.00.912.767.0ug/g0.9 ug/gDensityCreatinine
19458194611ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)14514.00.881.63.05.010.028.0688.0ug/g14.0 ug/g5.0 ug/gDensityCreatinine
19459194611ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-oxo-isononyl phthalate (oxo-MiNP)1457.60.571.32.75.614.0419.0ug/g7.6 ug/g2.7 ug/gDensityCreatinine
19460194611ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(carboxy-isooctyl) phthalate (MCOP)14524.02.03.05.08.214.037.01556.0ug/g24.0 ug/g8.2 ug/gDensityCreatinine
194610ChildrenMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDiNP metabolitesMono(carboxy-isooctyl) phthalate (MCOP)
Mono-hydroxy-isononyl phthalate (OH-MiNP)
Mono-isononyl phthalate (MiNP)
Mono-oxo-isononyl phthalate (oxo-MiNP)
14561.04.07.212.022.038.0102.03626.0ug/g61.0 ug/g22.0 ug/gDensityCreatinine
194620MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMonoethyl phthalate (MEP)14564.05.58.316.029.071.0298.0581.0ug/g64.0 ug/g29.0 ug/gDensityCreatinine
19463194651MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)14544.013.019.026.037.054.0100.0125.0ug/g44.0 ug/g37.0 ug/gDensityCreatinine
19464194651MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-n-butyl phthalate (MnBP)14524.04.69.515.021.029.041.072.0ug/g24.0 ug/g21.0 ug/gDensityCreatinine
194650MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDBP metabolitesMono-isobutyl phthalate (MiBP)
Mono-n-butyl phthalate (MnBP)
14567.018.028.044.061.082.0141.0186.0ug/g67.0 ug/g61.0 ug/gDensityCreatinine
194660MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMonobenzyl phthalate (MBzP)1455.52.54.16.817.032.0ug/g5.5 ug/g4.1 ug/gDensityCreatinine
19467194711MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)1456.41.01.73.07.5571.0ug/g6.4 ug/g1.7 ug/gDensityCreatinine
19468194711MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)14521.03.04.89.813.018.043.0647.0ug/g21.0 ug/g13.0 ug/gDensityCreatinine
19469194711MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)14510.02.43.96.28.619.0321.0ug/g10.0 ug/g6.2 ug/gDensityCreatinine
19470194711MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)14515.02.34.06.28.711.024.0480.0ug/g15.0 ug/g8.7 ug/gDensityCreatinine
194710MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDEHP metabolitesMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)
Mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)
Mono(2-ethylhexyl) phthalate (MEHP)
14570.09.816.028.040.052.0121.02700.0ug/g70.0 ug/g40.0 ug/gDensityCreatinine
194730MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(3-carboxypropyl) phthalate (MCPP)1455.21.52.43.46.013.089.0ug/g5.2 ug/g3.4 ug/gDensityCreatinine
19474194781MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-isononyl phthalate (MiNP)14515.00.31.66.1ug/g0.3 ug/gDensityCreatinine
19475194781MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)1455.10.581.42.65.417.053.0ug/g5.1 ug/g2.6 ug/gDensityCreatinine
19476194781MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono-oxo-isononyl phthalate (oxo-MiNP)1452.70.611.32.69.923.0ug/g2.7 ug/g1.3 ug/gDensityCreatinine
19477194781MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisMono(carboxy-isooctyl) phthalate (MCOP)1459.92.03.35.29.937.0106.0ug/g9.9 ug/g5.2 ug/gDensityCreatinine
194780MothersMother-child pairs in rural and urban DenmarkDenmarkDKUrine, first morning spotLC-MS/MS after enzymatic hydrolysisDiNP metabolitesMono(carboxy-isooctyl) phthalate (MCOP)
Mono-hydroxy-isononyl phthalate (OH-MiNP)
Mono-isononyl phthalate (MiNP)
Mono-oxo-isononyl phthalate (oxo-MiNP)
14524.00.883.97.612.024.081.0240.0ug/g24.0 ug/g12.0 ug/gDensityCreatinine

Intake values

No data available

Correlation values

No data available

Reproducibility values

No data available