Fromme 2007

ID522
TitleOccurrence and daily variation of phthalate metabolites in the urine of an adult population
AuthorsFromme, H.; Bolte, G.; Koch, H. M.; Angerer, J.; Boehmer, S.; Drexler, H.; Mayer, R.; Liebl, B.
Year2007
JournalInt J Hyg Environ Health
Volume210
Issue1
Pages21-33
PubMed ID17182278
DOI10.1016/j.ijheh.2006.09.005

Subjects

IDParent IDDepthSubject groupPopulationCountryCountry codeEthnicityCohortHealth conditionSmoker proportionSupplement users excluded?GenderFemale proportionSizeAge meanAge SDAge minAge maxAge medianHeight meanHeight SDHeight minHeight maxHeight medianWeight meanWeight SDWeight minWeight maxWeight medianBMI meanBMI SDBMI minBMI maxBMI median
16990AllAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)HealthyUnspecifiedFemale + Male54.05014.060.042.0107.0
170016991MalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)HealthyUnspecifiedMale0.02333.076.0
170116991FemalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)HealthyUnspecifiedFemale100.02735.066.0

Biomarker concentration values

IDParent IDDepthSubject groupPopulationCountryCountry codeCohortTime definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianAdjustment typeAdjusted onRegressed onExpressed as
197470MalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-n-butyl phthalate (MnBP)2346.722.929.241.472.373.686.9ug/g46.7 ug/g41.4 ug/gDensityCreatinine
197480MalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)2347.721.025.049.775.177.7113.3ug/g47.7 ug/g49.7 ug/gDensityCreatinine
197490MalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMonobenzyl phthalate (MBzP)238.02.83.55.114.716.520.9ug/g8.0 ug/g5.1 ug/gDensityCreatinine
197500MalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)234.41.42.44.36.57.17.5ug/g4.4 ug/g4.3 ug/gDensityCreatinine
197510MalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)2312.36.78.412.116.118.620.3ug/g12.3 ug/g12.1 ug/gDensityCreatinine
197520MalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)2318.18.712.318.523.624.324.4ug/g18.1 ug/g18.5 ug/gDensityCreatinine
197530MalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)2322.612.815.021.132.334.335.1ug/g22.6 ug/g21.1 ug/gDensityCreatinine
197540MalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)237.63.24.97.910.311.312.3ug/g7.6 ug/g7.9 ug/gDensityCreatinine
197550MalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)236.72.02.94.89.59.537.4ug/g6.7 ug/g4.8 ug/gDensityCreatinine
197560MalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-oxo-isononyl phthalate (oxo-MiNP)233.61.11.62.65.97.317.9ug/g3.6 ug/g2.6 ug/gDensityCreatinine
197570FemalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-n-butyl phthalate (MnBP)2755.630.633.746.883.095.0172.8ug/g55.6 ug/g46.8 ug/gDensityCreatinine
197580FemalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)2751.917.020.845.288.589.693.1ug/g51.9 ug/g45.2 ug/gDensityCreatinine
197590FemalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMonobenzyl phthalate (MBzP)2711.63.13.87.620.821.283.9ug/g11.6 ug/g7.6 ug/gDensityCreatinine
197600FemalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)275.30.22.14.311.011.012.4ug/g5.3 ug/g4.3 ug/gDensityCreatinine
197610FemalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)2716.75.48.514.926.242.246.8ug/g16.7 ug/g14.9 ug/gDensityCreatinine
197620FemalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)2721.78.010.418.345.453.063.0ug/g21.7 ug/g18.3 ug/gDensityCreatinine
197630FemalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)2729.46.815.525.342.969.080.1ug/g29.4 ug/g25.3 ug/gDensityCreatinine
197640FemalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)279.94.54.88.816.422.131.6ug/g9.9 ug/g8.8 ug/gDensityCreatinine
197650FemalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-oxo-isononyl phthalate (oxo-MiNP)273.80.71.52.87.18.911.4ug/g3.8 ug/g2.8 ug/gDensityCreatinine
197660FemalesAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)276.41.22.85.411.513.221.0ug/g6.4 ug/g5.4 ug/gDensityCreatinine

Intake values

No data available

Correlation values

No data available

Reproducibility values

IDMst. IDSubject groupPopulationCountryCountry codeCohortTime definitionBiological specimenExperimental methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BS
80119735AllAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-n-butyl phthalate (MnBP)ug/gCreatinine500.45
80219736AllAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-isobutyl phthalate (MiBP)ug/gCreatinine500.44
80319737AllAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMonobenzyl phthalate (MBzP)ug/gCreatinine500.58
80419738AllAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethylhexyl) phthalate (MEHP)ug/gCreatinine500.34
80519739AllAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-oxohexyl) phthalate (MEOHP)ug/gCreatinine500.24
80619740AllAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)ug/gCreatinine500.2
80719741AllAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-ethyl-5-carboxypentyl) phthalate (MECPP)ug/gCreatinine500.3
80819742AllAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono(2-carboxymethylhexyl) phthalate (MCMHP)ug/gCreatinine500.29
80919743AllAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-oxo-isononyl phthalate (oxo-MiNP)ug/gCreatinine500.37
81019744AllAdults from southern GermanyGermanyDEINES (Integrated Exposure Assessment Survey)baseline; 1 day; 2 days; 3 days; 4 days; 5 days; 6 days; 7 daysUrine, spotLC-MS/MS after enzymatic hydrolysisMono-hydroxy-isononyl phthalate (OH-MiNP)ug/gCreatinine500.4