ID1027
NamePCB-74
Synonyms2,4,4',5-Tetrachlorobiphenyl
StructureThumb
Description
ClassificationCompounds > Pollution > Air and water pollutants > Polychlorinated biphenyls (PCB)
CAS number32690-93-0
PubChem ID36218
ChEBI ID
FooDB ID
HMDB ID

Chemical data

MolDBi data

IUPAC Name1,2,4-trichloro-5-(4-chlorophenyl)benzene
Traditional IUPAC Name2,4,4',5-tetrachlorobiphenyl
FormulaC12H6Cl4
InChIInChI=1S/C12H6Cl4/c13-8-3-1-7(2-4-8)9-5-11(15)12(16)6-10(9)14/h1-6H
InChI KeyTULCXSBAPHCWCF-UHFFFAOYSA-N
Molecular weight291.988
Exact mass289.92236102
SMILESClC1=CC=C(C=C1)C1=CC(Cl)=C(Cl)C=C1Cl

ClassyFire Taxonomy

Description belongs to the class of organic compounds known as polychlorinated biphenyls. These are organic compounds containing at least two chlorine atoms attached to either benzene ring of the biphenyl moiety.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBiphenyls and derivatives
Direct ParentPolychlorinated biphenyls
Alternative Parents

Publications with PCB-74

TitleFirst authorYear
Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls in blood and breast milk collected from pregnant women in Sapporo City, JapanTodaka2011
Relationship between the concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls in maternal blood and those in breast milkTodaka2010
Plasma concentrations of selected organobromine compounds and polychlorinated biphenyls in postmenopausal women of Québec, CanadaSandanger2007
High postnatal exposures to polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) via breast milk in California: does BDE-209 transfer to breast milk?Park2011
Distribution of polybrominated diphenyl ethers (PBDEs) and other persistent organic pollutants in human serum from GreeceKalantzi2011
Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in breast milk from the Pacific NorthwestShe2007
Blood pressure in relation to concentrations of PCB congeners and chlorinated pesticidesGoncharov2011
Associations between prenatal exposure to polychlorinated biphenyls and neonatal thyroid-stimulating hormone levels in a Mexican-American population, Salinas Valley, CaliforniaChevrier2007
Assessment of exposure to polychlorinated biphenyls: analysis of selected isomers in blood and adipose tissueLuotamo1991
Exposure to polychlorinated biphenyl (PCB) congeners measured shortly after giving birth and subsequent risk of maternal breast cancer before age 50Cohn2012
Concentrations of polychlorinated biphenyls in blood of Yusho patients over 35 years after the incidentTodaka2009
Distribution of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in human serum from urban areas in KoreaKang2008
Effects of exposure to polychlorinated biphenyls and organochlorine pesticides on thyroid function during pregnancyChevrier2008
Congener-specific approach to human PCB concentrations by serum analysisPark2007
Environmental and occupational exposures and serum PCB concentrations and patterns among Mohawk men at AkwesasneFitzgerald2007
High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American populationGoncharov2008
Dioxin-like and non-dioxin-like PCBs in human serum of Slovak populationJursa2006
Concentrations of polychlorinated biphenyls in blood and the risk for testicular cancerHardell2004
Human exposure to polychlorinated biphenyls in a residential communityOrloff2003
In utero exposure to background levels of polychlorinated biphenyls and cognitive functioning among school-age childrenGray2005
Congener-specific analysis of polychlorinated biphenyl in human blood from JapaneseHirai2005
Birth delivery mode modifies the associations between prenatal polychlorinated biphenyl (PCB) and polybrominated diphenyl ether (PBDE) and neonatal thyroid hormone levelsHerbstman2008

Biomarker data

Measurements of PCB-74 in biospecimens

Concentration values

IDParent IDDepthSubject groupPopulationCountryCohortBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailMeasurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianConverted unitAdjustment typeAdjusted onRegressed onExpressed asPublication

Reproducibility values

IDExcretion IDSubject groupPopulationCountryCohortBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailArithmetic meanGeometric meanMedianUnitAdjusted onReproducibility sizeICCICC 95% CI lowerICC 95% CI upperCV% WSCV% BSVAR WSVAR BSPublication

Associations of PCB-74 with exposures

Correlation values

IDIntake IDExcretion IDSubject groupPopulationCountryCohortIntake Time definitionIntake Assessment methodIntakeIntake detailSupplement intakes included?Intake Arithmetic meanIntake Geometric meanIntake MedianIntake UnitIntake Adjusted onBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailBiomarker Arithmetic meanBiomarker Geometric meanBiomarker MedianBiomarker UnitBiomarker Adjusted onCorrelation sizeCorrelation typeCorrelation valueCorrelation 95% CI lowerCorrelation 95% CI upperCorrelation p-valueSignificant?Measurement adjustmentDeattenuated?CovariatesPublication

Metabolomic associations

IDIntake IDExcretion IDSubject groupPopulationCountryCohortNo. of subjectsIntake Assessment methodIntakeIntervention doseBiospecimenAnalytical methodBiomarkerStructural identificationFeature selectionArea under curveSensitivitySpecificityPLS-DA VIPBeta coefficientBeta coefficient p-valueANOVA p-valuePublication

Associations of PCB-74 with cancer risk

Cancer associations

IDExcretion IDSubject groupPopulationCountryCohortNo. of subjectsNo. of casesNo. of controlsBiospecimenAnalytical methodBiomarkerBiomarker detailCancerStudy designPublication

Exposure data

Measurements of PCB-74 exposures in populations

Intake values

IDParent IDDepthSubject groupPopulationCountryCohortIntake Time definitionIntake assessment toolIntake food coverageIntake time coverageIntake Assessment methodIntakeIntake detailFood descriptionSupplement intakes included?Measurement sizeDetected (nb)Detected (%)Detected only?Arithmethic meanArithmethic SDGeometric meanGeometric SDMinMin (detected)Percentile_05Percentile_10Percentile_25MedianPercentile_75Percentile_90Percentile_95MaxInterquartile rangeMean 95% CI lowerMean 95% CI upperGMean 95% CI lowerGMean 95% CI upperUnitConverted arithmetic meanConverted geometric meanConverted medianConverted unitAdjustment typeAdjusted onRegressed onExpressed asPublication

Associations of PCB-74 exposures with biomarkers

Correlation values

IDIntake IDExcretion IDSubject groupPopulationCountryCohortIntake Time definitionIntake Assessment methodIntakeIntake detailSupplement intakes included?Intake Arithmetic meanIntake Geometric meanIntake MedianIntake UnitIntake Adjusted onBiomarker Time definitionBiospecimenAnalytical methodBiomarkerBiomarker detailBiomarker Arithmetic meanBiomarker Geometric meanBiomarker MedianBiomarker UnitBiomarker Adjusted onCorrelation sizeCorrelation typeCorrelation valueCorrelation 95% CI lowerCorrelation 95% CI upperCorrelation p-valueSignificant?Measurement adjustmentDeattenuated?CovariatesPublication