Exposome-Explorer: show components

PCB-183

ID	1125
Name	PCB-183
Synonyms	2,2',3,4,4',5',6-Heptachlorobiphenyl
Structure	MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure Structure for #<Compound:0xb08afccc>
Description
Group	Polychlorinated biphenyls (PCB)
Sub-group	Heptachlorobiphenyls
Exposure source	Pollution
Use
CAS number	52663-69-1
PubChem ID	40476
ChEBI ID
FooDB ID
HMDB ID

Title	First author	Year
Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls in blood and breast milk collected from pregnant women in Sapporo City, Japan	Todaka	2011
Relationship between the concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls in maternal blood and those in breast milk	Todaka	2010
Plasma concentrations of selected organobromine compounds and polychlorinated biphenyls in postmenopausal women of Québec, Canada	Sandanger	2007
Distribution of polybrominated diphenyl ethers (PBDEs) and other persistent organic pollutants in human serum from Greece	Kalantzi	2011
Assessment of the levels of persistent organic pollutants and 1-hydroxypyrene in blood and urine samples from Mexican children living in an endemic malaria area in Mexico	Trejo-Acevedo	2012
Blood pressure in relation to concentrations of PCB congeners and chlorinated pesticides	Goncharov	2011
Associations between prenatal exposure to polychlorinated biphenyls and neonatal thyroid-stimulating hormone levels in a Mexican-American population, Salinas Valley, California	Chevrier	2007
Breast adipose tissue concentrations of polychlorinated biphenyls and other organochlorines and breast cancer risk	Aronson	2000
Assessment of exposure to polychlorinated biphenyls: analysis of selected isomers in blood and adipose tissue	Luotamo	1991
Exposure to polychlorinated biphenyl (PCB) congeners measured shortly after giving birth and subsequent risk of maternal breast cancer before age 50	Cohn	2012
Distribution of PCBs, their hydroxylated metabolites, and other phenolic contaminants in human serum from two European countries	Dirtu	2010
Concentrations of polychlorinated biphenyls in blood of Yusho patients over 35 years after the incident	Todaka	2009
Distribution of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in human serum from urban areas in Korea	Kang	2008
Effects of exposure to polychlorinated biphenyls and organochlorine pesticides on thyroid function during pregnancy	Chevrier	2008
Congener-specific approach to human PCB concentrations by serum analysis	Park	2007
High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American population	Goncharov	2008
Dioxin-like and non-dioxin-like PCBs in human serum of Slovak population	Jursa	2006
Concentrations of polybrominated diphenyl ethers, polychlonnated biphenyls, and polychlorobiphenylols in serum from pregnant Faroese women and their children 7 years later	Fangstrom	2005
Concentrations of polychlorinated biphenyls in blood and the risk for testicular cancer	Hardell	2004
Human exposure to polychlorinated biphenyls in a residential community	Orloff	2003
Congener-specific analysis of polychlorinated biphenyl in human blood from Japanese	Hirai	2005
Distribution of polychlorinated biphenyls, organochlorine pesticides and polybrominated diphenyl ethers in human umbilical cord serum, maternal serum and milk from Wielkopolska region, Poland	Jaraczewska	2006

Analytical method
GC-HRMS
GC-MS
GC-ID-MS
GC-ID-HRMS
GC-ECD
GC-MS/MS

Biospecimen
Plasma, unspecified
Serum, fasting
Breast milk
Serum, unspecified
Adipose tissue, unspecified
Blood, unspecified
Cord serum
Adipose tissue, breast
Whole blood, unspecified

Cohort
Hokkaido Study on Environment and Children's Health
CHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas)
CHDS (Child Health and Development Studies)
Yusho victims
Health Assessment Study of Seoul Citizen

Biomarker

Biomarker concentration values

ID	Parent ID	Depth	Subject group	Population	Country	Country code	Cohort	Time definition	Biospecimen	Analytical method	Biomarker	Measurement size	Detected (nb)	Detected (%)	Arithmethic mean	Arithmethic SD	Geometric mean	Min	Percentile_10	Percentile_25	Median	Percentile_75	Percentile_90	Max	GMean 95% CI lower	GMean 95% CI upper	Unit	Converted arithmetic mean	Converted geometric mean	Converted median	Adjustment type	Adjusted on	Publication
12170	12388	2	All	Pregnant women in Sapporo City	Japan	JP	Hokkaido Study on Environment and Children's Health	delivery + 1 week	Blood, unspecified	GC-HRMS	PCB-183	97			1924.0	1120.0		5.0			1651.0			6387.0			pg/g	0.0 ug/g		0.0 ug/g	Density	Lipid	Todaka 2011
12171	12389	2	All	Pregnant women in Sapporo City	Japan	JP	Hokkaido Study on Environment and Children's Health	delivery + 1 month	Breast milk	GC-HRMS	PCB-183	97			1170.0	613.0		216.0			1064.0			3734.0			pg/g	0.0 ug/g		0.0 ug/g	Density	Lipid	Todaka 2011
12582	12616	2	All	Primiparous mothers in Sapporo City	Japan	JP	Hokkaido Study on Environment and Children's Health		Blood, unspecified	GC-HRMS	PCB-183	119			2192.0	1544.0		647.0			1853.0			11206.0			pg/g	0.0 ug/g		0.0 ug/g	Density	Lipid	Todaka 2010
12583	12617	2	All	Primiparous mothers in Sapporo City	Japan	JP	Hokkaido Study on Environment and Children's Health		Breast milk	GC-HRMS	PCB-183	119			1436.0	992.0		521.0			1231.0			8141.0			pg/g	0.0 ug/g		0.0 ug/g	Density	Lipid	Todaka 2010
13808	13817	1	All	Postmenopausal women from Quebec at a mammography clinic	Canada	CA			Plasma, unspecified	GC-MS	PCB-183	109		96.0	3.09		2.71	0.0						9.3			ng/g	0.0 ug/g	0.0 ug/g		Density	Lipid	Sandanger 2007
13963	13969	1	All	Subjects with (computer clerks of a large computer company in Athens) or without (general population in the Attika region) full-time computer work	Greece	GR			Serum, unspecified	GC-MS	PCB-183	61		100.0	2.97	1.94		0.49			2.34			8.28			ng/g	0.0 ug/g		0.0 ug/g	Density	Lipid	Kalantzi 2011
14486	14488	1	All	Children living in an endemic malaria area	Mexico	MX			Plasma, unspecified	GC-MS	PCB-183	45					0.0	0.0		0.0	0.0	0.0	0.0	0.0			ng/g		0.0 ug/g	0.0 ug/g	Density	Lipid	Trejo-Acevedo 2012
15447	15424	1	All	Residents of Anniston near the Monsanto plant	United States	US			Serum, fasting	GC-ID-MS	PCB-183	394	365	92.64	0.06	0.18		0.0			0.027			3.08			ng/g	0.0 ug/g		0.0 ug/g	Crude		Goncharov 2011
15487	15471	1	All	Pregnant women from the Salinas Valley	United States	US	CHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas)		Serum, unspecified	GC-ID-HRMS	PCB-183	259		78.0			0.3	0.0						8.2	0.3	0.4	ng/g		0.0 ug/g		Density	Lipid	Chevrier 2007
15499		0	Cases	Cases in a case-control study on breast cancer	Canada	CA			Adipose tissue, breast	GC-ECD	PCB-183	217					10.3								9.6	11.1	ng/g		0.0 ug/g		Crude		Aronson 2000
15517		0	Controls	Controls in a case-control study on breast cancer	Canada	CA			Adipose tissue, breast	GC-ECD	PCB-183	213					9.5								8.8	10.2	ng/g		0.0 ug/g		Crude		Aronson 2000
15562		0	Environmental exposure	Subjects non-occupationally exposed to PCBs	Finland	FI			Serum, unspecified	GC-ECD	PCB-183	30			1.4	1.2		0.0			1.87			3.7			ug/L	0.0 mg/L		0.0 mg/L	Crude		Luotamo 1991
15574		0	Short-term occupational exposure	Subjects with a short-term occupational exposure to PCBs (capacitor leaks, fires, explosions)	Finland	FI			Serum, unspecified	GC-ECD	PCB-183	31			0.23	0.09		0.1			0.3			0.3			ug/L	0.0 mg/L		0.0 mg/L	Crude		Luotamo 1991
15586		0	Long-term occupational exposure	Subjects with a long-term occupational exposure to PCBs in capacitor manufacture	Finland	FI			Serum, unspecified	GC-ECD	PCB-183	21			0.69	1.4		0.0			0.12			5.7			ug/L	0.0 mg/L		0.0 mg/L	Crude		Luotamo 1991
15610		0	Burnt Clophen A30 exposure	Subjects exposed to burnt Clophen A30 in a fire in the electricity room of a pulp mill	Finland	FI		accident + 1 day	Adipose tissue, unspecified	GC-ECD	PCB-183	12			30.62	15.96		11.1						62.0			ng/g	0.0 ug/g			Crude		Luotamo 1991
15634		0	Burnt Clophen A30 exposure	Subjects exposed to burnt Clophen A30 in a fire in the electricity room of a pulp mill	Finland	FI		accident + 1 month	Adipose tissue, unspecified	GC-ECD	PCB-183	12			19.86	20.19		0.8						75.5			ng/g	0.0 ug/g			Crude		Luotamo 1991
15738		0	Controls	Controls in a case-control study on breast cancer	United States	US	CHDS (Child Health and Development Studies)		Serum, unspecified	GC-ECD	PCB-183	117		66.0						0.13	0.23	0.35					mmol/L			230000.0 nmol/L	Crude		Cohn 2012
15754		0	Cases	Cases in a case-control study on breast cancer	United States	US	CHDS (Child Health and Development Studies)		Serum, unspecified	GC-ECD	PCB-183	123		66.0						0.1	0.23	0.33					mmol/L			230000.0 nmol/L	Crude		Cohn 2012
15948	15952	1	All [Romania]	General population in a highly organochlorine pesticide contaminated area in the Eastern part of Romania	Romania	RO			Serum, unspecified	GC-MS	PCB-183	53		98.0				0.0			73.0			405.0			pg/mL			0.0 mg/L	Crude		Dirtu 2010
15979	15983	1	All [Belgium]	General population with low levels of organohalogenated contaminants in human serum in Belgium	Belgium	BE			Serum, unspecified	GC-MS	PCB-183	20		95.0				0.0			70.0			160.0			pg/mL			0.0 mg/L	Crude		Dirtu 2010
16050	16068	2	Exposed	Yusho patients and Yusho-suspected subjects 35 years after the incident	Japan	JP	Yusho victims		Blood, unspecified	GC-HRMS	PCB-183	242			9470.0	8265.0		656.0			7196.0			68668.0			pg/g	0.0 ug/g		0.0 ug/g	Density	Lipid	Todaka 2009
16124	16142	2	Controls	Subjects in Fukuoka Prefecture	Japan	JP			Blood, unspecified	GC-HRMS	PCB-183	127			6155.0	3047.0		1694.0			5270.0			18124.0			pg/g	0.0 ug/g		0.0 ug/g	Density	Lipid	Todaka 2009
16184	16186	1	All	Urban adult residents in Seoul non-occupationally exposed to OCPs and PCBs	Korea, Republic of	KR	Health Assessment Study of Seoul Citizen		Serum, fasting	GC-MS/MS	PCB-183	40	4		0.0			0.0			0.0			12.2			ng/g	0.0 ug/g		0.0 ug/g	Density	Lipid	Kang 2008
16223	16207	1	All	Pregnant women in Salinas	United States	US	CHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas)		Serum, unspecified	GC-ID-HRMS	PCB-183	304		77.6			0.32	0.0						8.2	0.28	0.35	ng/g		0.0 ug/g		Density	Lipid	Chevrier 2008
16525	16547	2	All	Subjects in Seoul exposed (workers and residents) or not (living away) to three municipal solid waste incinerators	Korea, Republic of	KR			Serum, unspecified	GC-HRMS	PCB-183	87			3.41	3.19					2.31			18.47			ng/g	0.0 ug/g		0.0 ug/g	Density	Lipid	Park 2007
16644	16647	1	All	Adult Native American living in the Akwesasne Reservation area	Canada	CA			Serum, fasting	GC-ECD	PCB-183	277		84.2	0.04	0.002		0.0			0.03			0.35			ng/g	0.0 ug/g		0.0 ug/g	Crude		Goncharov 2008
16684		0	All	Subjects living (Michalovce district) or not (Stropkov and Svidnik districts) in a PCB-polluted area	Slovakia	SK			Serum, fasting	GC-HRMS	PCB-183	315			46.9			3.83	10.9		24.8		102.0	764.0			ng/g	0.0 ug/g		0.0 ug/g	Density	Lipid	Jursa 2006
16734		0	Mothers	Mothers and their children	Faroe Islands	FO		pregnancy	Serum, unspecified	GC-MS	PCB-183	57									40.0						ng/g			0.0 ug/g	Density	Lipid	Fangstrom 2005
16752		0	Mothers	Mothers and their children	Faroe Islands	FO		pregnancy	Serum, unspecified	GC-MS	PCB-183	57						24.0			100.0			430.0			pmol/g			0.0 umol/g	Density	Lipid	Fangstrom 2005
16770		0	Children	Mothers and their children	Faroe Islands	FO		pregnancy + 7 years	Serum, unspecified	GC-MS	PCB-183	42									21.0						ng/g			0.0 ug/g	Density	Lipid	Fangstrom 2005
16788		0	Children	Mothers and their children	Faroe Islands	FO		pregnancy + 7 years	Serum, unspecified	GC-MS	PCB-183	42						4.9			54.0			260.0			pmol/g			0.0 umol/g	Density	Lipid	Fangstrom 2005
16842	16860	1	Mothers of cases	Mothers of cases in a case-control study on testicular cancer	Sweden	SE			Blood, unspecified	GC-MS	PCB-183	44			16.0			4.7			14.0			48.0			ng/g	0.0 ug/g		0.0 ug/g	Density	Lipid	Hardell 2004
16880	16898	1	Mothers of controls	Mothers of controls in a case-control study on testicular cancer	Sweden	SE			Blood, unspecified	GC-MS	PCB-183	45			13.0			2.3			11.0			41.0			ng/g	0.0 ug/g		0.0 ug/g	Density	Lipid	Hardell 2004
16985	16997	1	Adults	Members of a residential community near a chemical plant that formerly manufactured PCBs	United States	US			Serum, unspecified	GC-ID-HRMS	PCB-183	43		53.5	227.4						33.0			4770.0			ng/L	0.0 mg/L		0.0 mg/L	Crude		Orloff 2003
17024	17036	1	Adults	Members of a residential community near a chemical plant that formerly manufactured PCBs	United States	US			Serum, unspecified	GC-ID-HRMS	PCB-183	43		53.5	41.8												ng/g	0.0 ug/g			Density	Lipid	Orloff 2003
17174	17180	2	All	Volunteers	Japan	JP			Whole blood, unspecified	GC-HRMS	PCB-183	24		100.0	11.0	6.0		4.6						22.9			pg/g	0.0 ug/g			Crude		Hirai 2005
17791	17796	1	All	Pregnant women from the Wielkopolska region	Poland	PL		delivery	Serum, unspecified	GC-MS	PCB-183	18		33.0	1.4	0.6		0.0			0.0			2.7			ng/g	0.0 ug/g		0.0 ug/g	Density	Lipid	Jaraczewska 2006
17810	17815	1	All	Pregnant women from the Wielkopolska region	Poland	PL		delivery	Cord serum	GC-MS	PCB-183	17		12.0	1.1	0.4		0.0			0.0			2.3			ng/g	0.0 ug/g		0.0 ug/g	Density	Lipid	Jaraczewska 2006

Intake values

No data available

Correlation values

No data available

Reproducibility values

No data available

PCB-183

Structure for #<Compound:0xb08afccc>

Biomarker measurements

Biomarker concentration values

Intake values

Correlation values

Reproducibility values